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Cigarette Smoking Induces Formation of 8-Hydroxydeoxyguanosine, One of the Oxidative Dna Damages in Human Peripheral Leukocytes
Abstract
Active oxygen species (AOS) such as O2- and H2O2 have been shown to be generated from both gas and tar phases of cigarette smoke and it has been suggested that they are involved in carcinogenesis due to cigarette smoking. Therefore, we investigated the effect of cigarette smoking on oxidative DNA damages in human peripheral blood cells using 8-hydroxydeoxy-guanosine (8-OH-dG) as a marker. From ten healthy male volunteers aged 20-22 years, 5 ml of blood was taken before and 10 minutes after smoking 2 cigarettes in 10 minutes. After lysis of blood cell membranes leukocyte DNA was isolated using a DNA extractor and 8-OH-dG levels were determined using high performance liquid chromatography (HPLC) with electrochemical detection. The mean levels of 8-OH-dG increased significantly (P less than 0.05) from 3.3 +/- 0.8/10(6) dG (mean +/- SD) to 5.1 +/- 2.5 after smoking. These results indicate that cigarette smoking induces oxidative DNA damage in peripheral blood cells in a relatively short time.
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Citations
Cites
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
Cited by
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Smith, S. M., Zwart, S. R., Block, G., Rice, B. L., & Davis-Street, J. E. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.437 · Cited by 316
Metadata
- Authors
- Kiyosawa, H., Suko, M., Okudaira, H., Murata, K., Miyamoto, E., Chung, M.-H., Kasai, H., & Nishimura, S.
- Venue
- Free Radical Research Communications
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 11
- Issue
- 1-3
- Pages
- 23-27
- ISSN
- 8755-0199 (ISSN-L)
- OpenAlex
- W2039197909
- Cited by
- 179
- References
- 1
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cigarette Smoking Induces Formation of 8-Hydroxydeoxyguanosine, One of the Oxidative Dna Damages in Human Peripheral Leukocytes. https://app.cochat.ai/papers/10.3109/10715769009109664
- The paper
- Kiyosawa, H., Suko, M., Okudaira, H., Murata, K., Miyamoto, E., Chung, M.-H., Kasai, H., & Nishimura, S. (1990). Cigarette Smoking Induces Formation of 8-Hydroxydeoxyguanosine, One of the Oxidative Dna Damages in Human Peripheral Leukocytes. Free Radical Research Communications. https://doi.org/10.3109/10715769009109664
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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