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Cited by 463

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Antioxidant Activity of Phytoestrogenic Isoflavones

Ruiz-Larrea, M. Begoña, Mohan, Aarthi R., Paganga, George, Miller, Nicholas J., Bolwell, G. Paul, Rice-Evans, Catherine A.·1997·Free Radical Research

Abstract

The aim of this work was to determine the antioxidant activities of a range of phytoestrogenic isoflavones. The antioxidant activity in the aqueous phase was determined by means of the ABTS.+ total antioxidant activity assay. The results show that the order of reactivity in scavenging the radical in the aqueous phase is genistein > daidzein = genistin approximately equal to biochanin A = daidzin > formononetin approximately equal to ononin, the latter displaying no antioxidant activity. The importance of the single 4'-hydroxyl group in the reactivity of the isoflavones, as scavengers of aqueous phase radicals, as well as the 5'7-dihydroxy structure is demonstrated. Examination of their abilities to enhance the resistance of low density lipoproteins to oxidation supports the observation that genistein is the most potent antioxidant among this family of compound studied, both in the aqueous and in the lipophilic phases.

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Metadata

Authors
Ruiz-Larrea, M. B., Mohan, A. R., Paganga, G., Miller, N. J., Bolwell, G. P., & Rice-Evans, C. A.
Venue
Free Radical Research
Published
1997-01
Volume
26
Issue
1
Pages
63-70
ISSN
  • 1029-2470 (ISSN-L)
  • 1071-5762
OpenAlex
W2157390407
Cited by
463
References
1
FWCI
10.97
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Antioxidant Activity of Phytoestrogenic Isoflavones. https://app.cochat.ai/papers/10.3109/10715769709097785
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Ruiz-Larrea, M. B., Mohan, A. R., Paganga, G., Miller, N. J., Bolwell, G. P., & Rice-Evans, C. A. (1997). Antioxidant Activity of Phytoestrogenic Isoflavones. Free Radical Research. https://doi.org/10.3109/10715769709097785

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