Exploratory design in medical nanotechnology: a mechanical artificial red cell.
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Molecular manufacturing promises precise control of matter at the atomic and molecular level, allowing the construction of micron-scale machines comprised of nanometer-scale components. Medical nanomachines will be among the earliest applications. The artificial red blood cell or "respirocyte" proposed here is a bloodborne spherical 1-micron diamondoid 1000-atm pressure vessel with active pumping powered by endogenous serum glucose, able to deliver 236 times more oxygen to the tissues per unit volume than natural red cells and to manage carbonic acidity. An onboard nanocomputer and numerous chemical and pressure sensors enable complex device behaviors remotely reprogrammable by the physician via externally applied acoustic signals.
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Advanced nanomedicine - specifically, medical nanorobotics - is expected to serve as a dynamic tool toward addressing most human brain disorders.
“The pursuit of ever smaller tools to treat patients is approaching a pivotal juncture in medical history as advanced nanomedicine — specifically, medical nanorobotics — is expected to serve as a dynamic tool toward addressing most human brain disorders.”
From Human Brain/Cloud Interface (2019) · cites this paper as Freitas, 1998
The FREITAS section says medical nanorobots have been proposed to repair brain damage, supporting a possible role in a brain-related condition. It does not say they are expected to address most human brain disorders; the paper instead develops a preliminary design for an artificial red blood cell. No page number is available in our copy. (LLM, conf=0.85)
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Sanap Gajanan, S., & Laddha Sachin, S. (2011) · International Research Journal of Pharmacy · Cited by 5 · see citing works
- Authors
- Frcitas, R. A.
- Corresponding author
- Frcitas, Robert A.
- Venue
- Artificial Cells, Blood Substitutes, and Biotechnology
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 26
- Issue
- 4
- Pages
- 411-430
- ISSN
- 1055-7172 (ISSN-L)
- 1073-1199
- 1532-4184
- OpenAlex
- W2101322365
- Cited by
- 167
- References
- 15
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 13 · 2013: 5 · 2012: 11
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Artificial Cells Blood Substitutes and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Molecular Communication and Nanonetworks
- Keywords
- molecular manufacturing, oxygen delivery, nanocomputers, blood substitutes
- MeSH terms
- Biocompatible Materials, Blood Substitutes, Humans, Male, Models, Theoretical, Oxygen, Medical Laboratory Science
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