Nanoparticle-based therapy for respiratory diseases
Open accessAbstract
Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical reality. In addition, studies are still required to determine the potential of nanotherapy and the systemic toxicity of nanomaterials for future human use.
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NPs facilitate drug delivery directly to target tissues, improving lung deposition and therapeutic effects of anti-asthmatic drugs while attenuating adverse side effects.
“NPs facilitate drug delivery directly to the target tissues, thus improving the lung deposition and eventually the therapeutic effects of anti-asthmatic drugs while attenuating the adverse side effects.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [168]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
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Self-citation
- Authors
- SILVA, A. L. D., SANTOS, R. S., XISTO, D. G., ALONSO, S. D. V., MORALES, M. M., & ROCCO, P. R. M.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- National University of Quilmes (AR)
- Universidade Federal do Rio de Janeiro, Brasil
- Venue
- Anais da Academia Brasileira de Ciências
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2013-03-05
- Volume
- 85
- Issue
- 1
- Pages
- 137-146
- ISSN
- 0001-3765 (ISSN-L)
- OpenAlex
- W2125126644
- Cited by
- 42
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Anais da Academia Brasileira de Ciências (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- nanoparticles, nanomedicine, respiratory diseases, lung disease, nanoparticle formulation, lung remodeling, nanomaterial toxicity, nanotherapy
- MeSH terms
- Asthma, Humans, Lung Diseases, Lung Neoplasms, Tuberculosis, Pulmonary, Drug Delivery Systems, Nanoparticles
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