Cited by 114Health, Environment, Cognitive AgingMetabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks

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Biomarkers intersect with the exposome

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Rappaport, Stephen M.·2012·Biomarkers

DOI 10.3109/1354750x.2012.691553PMC PMC4763608

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Abstract

The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

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Authors: Rappaport, S. M.
Affiliations: University of California, Berkeley (US)
Corresponding author: Rappaport, Stephen M.
ORCID: Rappaport, Stephen M.
Venue: Biomarkers
Publisher: Informa UK Limited
Published: 2012-06-07
Volume: 17
Issue: 6
Pages: 483-489
ISSN: 1354-750X (ISSN-L)
1366-5804
DOI: 10.3109/1354750x.2012.691553
PMC: PMC4763608
OpenAlex: W1977512191
Cited by: 114
References: 68
Citations by year: 2025: 4 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 17 · 2013: 10
FWCI: 9.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biomarkers (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (U54ES016115, P42ES004705)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: exposome, biomarkers of exposure, disease biomarkers, exposome-wide association studies, serum metabolomics, serum proteomics, disease causality, disease prevention, diagnosis, prognosis, treatment
MeSH terms: Blood Proteins, Cardiovascular Diseases, Environmental Exposure, Humans, Neoplasms, Biomarkers, Neurodegenerative Diseases, Proteome, Proteomics, Metabolomics, Metabolome

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Biomarkers intersect with the exposome

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