Cited by 59Reproductive Health and ContraceptionEstrogen and related hormone effectsAdrenal Hormones and Disorders

Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function

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Ågren, Ulla M., Anttila, Marjatta, Mäenpää-Liukko, Kristiina, Rantala, Maija-Liisa, Rautiainen, Hilkka, Sommer, Werner F., Mommers, Ellen·2011·The European Journal of Contraception & Reproductive Health Care

Abstract

OBJECTIVES: To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17β-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). METHODS: Randomised, open-label, multi-centre trial involving 121 healthy women, aged 18-50 years old. Participants received NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen (n=60) or LNG/EE (150 μg/30 μg) in a 21/7-day regimen (n=61) for six cycles. The primary outcome was the change from baseline to cycle 6 in markers of adrenal and thyroid function, androgens, and SHBG. RESULTS: Total cortisol, corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG) increased from baseline in both groups, with significantly greater increases in the LNG/EE group. No relevant changes from baseline or differences between the groups were observed for thyroid-stimulating hormone (TSH) and free thyroxine (T4). Androgens and androgen precursors decreased from baseline in both groups, with significantly greater decreases in the LNG/EE group (except for free testosterone). A greater increase in SHBG was observed with NOMAC/E2 than with LNG/EE. CONCLUSIONS: NOMAC/E2 has significantly less influence on markers of adrenal and thyroid function and androgens than LNG/EE. The clinical relevance of these findings requires further study.

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Authors
Ågren, U. M., Anttila, M., Mäenpää-Liukko, K., Rantala, M.-L., Rautiainen, H., Sommer, W. F., & Mommers, E.
Affiliations
MSD (Netherlands) (NL)
Corresponding author
Ågren, Ulla M.
Venue
The European Journal of Contraception & Reproductive Health Care
Published
2011-09-26
Volume
16
Issue
6
Pages
458-467
ISSN
  • 1362-5187 (ISSN-L)
  • 1473-0782
OpenAlex
W2076702065
Cited by
59
References
28
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 8 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 8 · 2012: 6
FWCI
7.53
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • The European Journal of Contraception & Reproductive Health Care (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
nomegestrol acetate, estradiol, levonorgestrel, ethinyl estradiol, endocrine function, adrenal function, thyroid function, sex hormone-binding globulin, androgens, cortisol, corticosteroid-binding globulin, thyroxine-binding globulin, thyroid-stimulating hormone, free thyroxine, free testosterone
MeSH terms
Adolescent, Adult, Contraceptives, Oral, Combined, Contraceptives, Oral, Synthetic, Estradiol, Estrogens, Ethinyl Estradiol, Female, Humans, Hydrocortisone, Megestrol, Middle Aged, Norpregnadienes, Sex Hormone-Binding Globulin, Transcortin, Levonorgestrel, Testosterone Congeners, Young Adult, Thyroxine-Binding Globulin

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