Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function
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OBJECTIVES: To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17β-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). METHODS: Randomised, open-label, multi-centre trial involving 121 healthy women, aged 18-50 years old. Participants received NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen (n=60) or LNG/EE (150 μg/30 μg) in a 21/7-day regimen (n=61) for six cycles. The primary outcome was the change from baseline to cycle 6 in markers of adrenal and thyroid function, androgens, and SHBG. RESULTS: Total cortisol, corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG) increased from baseline in both groups, with significantly greater increases in the LNG/EE group. No relevant changes from baseline or differences between the groups were observed for thyroid-stimulating hormone (TSH) and free thyroxine (T4). Androgens and androgen precursors decreased from baseline in both groups, with significantly greater decreases in the LNG/EE group (except for free testosterone). A greater increase in SHBG was observed with NOMAC/E2 than with LNG/EE. CONCLUSIONS: NOMAC/E2 has significantly less influence on markers of adrenal and thyroid function and androgens than LNG/EE. The clinical relevance of these findings requires further study.
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The lower impact of natural estrogens on hormone-binding globulins has also been observed comparing E2 + nomegestrol acetate with EE + LNG.
“and E2 + nomegestrol acetate with EE + LNG (Ågren et al., 2011).”
From Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial (2023) · cites this paper as Ågren et al., 2011
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- Authors
- Ågren, U. M., Anttila, M., Mäenpää-Liukko, K., Rantala, M.-L., Rautiainen, H., Sommer, W. F., & Mommers, E.
- Affiliations
- MSD (Netherlands) (NL)
- Corresponding author
- Ågren, Ulla M.
- Venue
- The European Journal of Contraception & Reproductive Health Care
- Publisher
- Informa UK Limited
- Published
- 2011-09-26
- Volume
- 16
- Issue
- 6
- Pages
- 458-467
- ISSN
- 1362-5187 (ISSN-L)
- 1473-0782
- PMC
- PMC3233273
- OpenAlex
- W2076702065
- Cited by
- 59
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 8 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 8 · 2012: 6
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- The European Journal of Contraception & Reproductive Health Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- nomegestrol acetate, estradiol, levonorgestrel, ethinyl estradiol, endocrine function, adrenal function, thyroid function, sex hormone-binding globulin, androgens, cortisol, corticosteroid-binding globulin, thyroxine-binding globulin, thyroid-stimulating hormone, free thyroxine, free testosterone
- MeSH terms
- Adolescent, Adult, Contraceptives, Oral, Combined, Contraceptives, Oral, Synthetic, Estradiol, Estrogens, Ethinyl Estradiol, Female, Humans, Hydrocortisone, Megestrol, Middle Aged, Norpregnadienes, Sex Hormone-Binding Globulin, Transcortin, Levonorgestrel, Testosterone Congeners, Young Adult, Thyroxine-Binding Globulin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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