Symptoms and treatment of bipolar patients in Sweden
Abstract
OBJECTIVE: The objective of the study was to investigate affective symptoms and pharmacological treatment in bipolar I disorder patients, and to test whether self-rated symptoms could predict hospital admissions during a 12-month follow-up period. METHODS: A total of 231 outpatients with clinical bipolar I disorder were recruited. The clinical diagnoses were reassessed by a semi-structured interview. Twenty-four patients (10%) was reclassified as bipolar disorder type II or schizoaffective disorder (bipolar type). Medication status was recorded and symptoms were assessed with the self-rating scale AS-18. Patients were prospectively followed for 12 months and hospitalizations during that time were recorded. RESULTS: More than half (60%) rated themselves as normothymic. Mixed affective symptoms were more common than either depressive or manic/hypomanic symptoms. The admission rate during 1 year of follow-up was 13% (95% C.I. 8-17%). Patients which at baseline rated themselves high in either mania or in depression had a significantly increased risk for hospitalization (OR = 3.15; 95% C.I. 1.38-7.19). CONCLUSIONS: The findings should encourage clinicians to use patient self ratings in order to identify patients with a high risk for hospitalization for targeted interventions.
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Bipolar disorder patients are much less likely to be treated with antipsychotic medication.
“Also, bipolar disorder patients are much less likely to be treated with antipsychotic medication.”
From Life expectancy and death by diseases of the circulatory system in patients with bipolar disorder or schizophrenia in the Nordic countries. (2013) · cites this paper as [42]
The difference in antipsychotic treatment might at least partially explain the difference in cardiovascular mortality outcome found in this study.
“The difference in antipsychotic treatment might at least partially explain the difference in cardiovascular mortality outcome found in this study.”
From Life expectancy and death by diseases of the circulatory system in patients with bipolar disorder or schizophrenia in the Nordic countries. (2013) · cites this paper as [42]
Cites
SCAN: Schedules fonr Clinical Assessment in Neuropsychiatry
Wing, J. K. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810180089012 · Cited by 2,517 · see citing works
Regier, D. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800350011002 · Cited by 1,737 · see citing works
Prevalence and incidence studies of anxiety disorders: A systematic review of the literature
Somers, J. M., Goldner, E. M., Waraich, P., & Hsu, L. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100206 · Cited by 1,114 · see citing works
The emerging epidemiology of hypomania and bipolar II disorder
Angst, J. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00142-6 · Cited by 758 · see citing works
Perlis, R. H., Ostacher, M. J., Patel, J. K., Marangell, L. B., Zhang, H., Wisniewski, S. R., Ketter, T. A., Miklowitz, D. J., Otto, M. W., Gyulai, L., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.217 · Cited by 689 · see citing works
Affective disorders in five United States communities
Weissman, M. M., Leaf, P. J., Tischler, G. L., Blazer, D. G., Karno, M., BRUCE, M. L., & Florio, L. P. (1988) · Psychological Medicine · doi:10.1017/s0033291700001975 · Cited by 625 · see citing works
Perry, A., Tarrier, N., Morriss, R. K., McCarthy, E., & Limb, K. (1999) · BMJ · doi:10.1136/bmj.318.7177.149 · Cited by 588 · see citing works
Tohen, M. F. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810240026005 · Cited by 538 · see citing works
Prevalence and Incidence Studies of Mood Disorders: A Systematic Review of the Literature
Waraich, P., Goldner, E. M., Somers, J. M., & Hsu, L. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900208 · Cited by 522 · see citing works
The McLean-Harvard First-Episode Mania Study: Prediction of Recovery and First Recurrence
Tohen, M. F., Zarate, C. A., Hennen, J. A., Khalsa, H.-M. K., Strakowski, S. M., Gebre‐Medhin, P., Salvatore, P., & Baldessarini, R. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2099 · Cited by 471 · see citing works
Keck, P., McElroy, S. L., Strakowski, S. M., West, S. A., Sax, K. W., Hawkins, J. M., Bourne, M. L., & Haggard, P. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.5.646 · Cited by 456 · see citing works
Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania
McElroy, S. L., Keck, P. E., Pope, H. G., Hudson, J. I., Faedda, G. L., & Swann, A. C. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.12.1633 · Cited by 428 · see citing works
Suicidal Behaviour in Bipolar Disorder
Tondo, L., Isacsson, G., & Baldessarini, R. J. (2003) · CNS Drugs · doi:10.2165/00023210-200317070-00003 · Cited by 399 · see citing works
Historical perspectives and natural history of bipolar disorder
Angst, J., & Sellaro, R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00909-4 · Cited by 393 · see citing works
Long-term symptomatic status of bipolar I vs. bipolar II disorders
Judd, L. L., Schettler, P. J., Akiskal, H. S., Maser, J., Coryell, W., Solomon, D., Endicott, J., & Keller, M. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003341 · Cited by 389 · see citing works
A prospective follow-up of patients with bipolar and primary unipolar affective disorder
Winokur, G. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820180059006 · Cited by 249 · see citing works
Maj, M., Pirozzi, R., Magliano, L., & Bartoli, L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.30 · Cited by 242 · see citing works
Suicidality in patients with pure and depressive mania
Dilsaver, S. C., Chen, Y. W., Swann, A. C., Shoaib, A. M., & Krajewski, K. J. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.9.1312 · Cited by 201 · see citing works
Recurrence of bipolar disorders and major depression
Angst, J., Gamma, A., Sellaro, R., Lavori, P. W., & Zhang, H. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0437-2 · Cited by 186 · see citing works
Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications
Baldessarini, R. J., Tondo, L., & Viguera, A. C. (1999) · Bipolar Disorders · doi:10.1034/j.1399-5618.1999.10106.x · Cited by 152 · see citing works
Effects of treatment latency on response to maintenance treatment in manic‐depressive disorders
Baldessarini, R. J., Tondo, L., Baethge, C., Lepri, B., & Bratti, I. M. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00385.x · Cited by 139 · see citing works
Maj, M. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.020202.x · Cited by 63 · see citing works
Wing, J. K. (1996) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00801900 · Cited by 49 · see citing works
Frequency and Nature of Rumination in Chronic Depression: A Preliminary Study
Pearson, M., Brewin, C. R., Rhodes, J., & McCarron, G. (2008) · Cognitive Behaviour Therapy · doi:10.1080/16506070801919224 · Cited by 43 · see citing works
Depressive mixed state: Testing different definitions
Benazzi, F. (2001) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2001.00919.x · Cited by 36 · see citing works
Psychiatric admissions and hospitalization costs in bipolar disorder in Sweden
Ösby, U., Tiainen, A., Backlund, L., Edman, G., Adler, M., Hällgren, J., Sennfält, K., van Baardewijk, M., & Sparén, P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.09.011 · Cited by 32 · see citing works
Self-citationAdler, M., Liberg, B., Andersson, S., Isacsson, G., & Hetta, J. E. (2008) · Nordic Journal of Psychiatry · doi:10.1080/08039480801960354 · Cited by 29 · see citing works
Self-citationBipolar II and the bipolar spectrum
Skeppar, P., & Adolfsson, R. (2006) · Nordic Journal of Psychiatry · doi:10.1080/08039480500504685 · Cited by 24 · see citing works
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Laursen, T. M., Wahlbeck, K., Hällgren, J., Westman, J., Ösby, U., Alinaghizadeh, H., Gissler, M., & Nordentoft, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067133 · Cited by 313 · see citing works
Self-citationCardiovascular mortality in bipolar disorder: a population-based cohort study in Sweden
Westman, J., Hällgren, J., Wahlbeck, K., Erlinge, D., Alfredsson, L., & Ösby, U. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002373 · Cited by 204 · see citing works
Self-citationHukic, D. S., Frisén, L., Backlund, L., Lavebratt, C., Landén, M., Träskman‐Bendz, L., Edman, G., Schalling, M., & Ösby, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067450 · Cited by 7 · see citing works
Self-citation
- Authors
- Adler, M., Backlund, L., Edman, G., & Ösby, U.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Adler, Mats
- Venue
- International Journal of Psychiatry in Clinical Practice
- Publisher
- Informa UK Limited
- Published
- 2012-03-21
- Volume
- 16
- Issue
- 3
- Pages
- 170-177
- ISSN
- 1365-1501 (ISSN-L)
- 1471-1788
- OpenAlex
- W2139725019
- Cited by
- 3
- References
- 28
- Citations by year
- 2013: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Psychiatry in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Stockholms Läns Landsting
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- bipolar I disorder, affective symptoms, self-reported symptoms, hospitalization risk, manic symptoms, depressive symptoms, bipolar II disorder, schizoaffective disorder, antipsychotic drugs, outpatients, risk prediction
- MeSH terms
- Adolescent, Adult, Affective Symptoms, Aged, Aged, 80 and over, Antidepressive Agents, Bipolar Disorder, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales, Recurrence, Sweden, Logistic Models, Antimanic Agents, Principal Component Analysis, Young Adult, Self Report, Suicidal Ideation, Diagnostic Self Evaluation
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