Gonadal status and physical performance in older men
Open accessAbstract
OBJECTIVE: To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants. METHODS: The study included 455 ≥ 65 year older men of InCHIANTI study, Italy, with complete data on testosterone levels, hand grip strength, cross-sectional muscle area (CSMA), short physical performance battery (SPPB). Linear models were used to test the relationship between gonadal status and determinants of physical performance. RESULTS: Three different groups of older men were created: (1) severely hypogonadal (N=23), total testosterone levels ≤ 230 ng /dl; (2) moderately hypogonadal (N=88), total testosterone >230 and < 350 ng/dl) and (3) eugonadal (N=344), testosterone levels ≥ 350 ng/dl. With increased severity of hypogonadal status, participants were significantly older while their BMI was substantially similar. In the age and BMI adjusted analysis, there was a significant difference in haemoglobin levels, hand grip strength and SPPB score (p for trend < 0.001) among three groups, with severely hypogonadal men having lower values of haemoglobin, muscle strength and physical performance. We found no association between testosterone group assignment and calf muscle mass and 4 m walking speed. In the multivariate analysis grip strength (p for trend = 0.004) and haemoglobin (p for trend < 0.0001) but not SPPB and other determinants of physical performance were significantly different between the three groups. CONCLUSIONS: In older men, gonadal status is independently associated with some determinants (haemoglobin and muscle strength) of physical performance.
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In men, total testosterone concentrations decrease by 1% per year and bioavailable testosterone by 2% per year from age 30 years.
“In men, total testosterone concentrations decrease by 1% per year and bioavailable testosterone by 2% per year from the age of 30 years.”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [77]
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- Authors
- Maggio, M., Ceda, G. P., Lauretani, F., Bandinelli, S., Metter, E. J., Guralnik, J. M., Basaria, S., Cattabiani, C., Luci, M., Dall'Aglio, E., Vignali, A., Volpi, R., Valenti, G., & Ferrucci, L.
- Affiliations
- University of Parma (IT)
- Azienda Sanitaria di Firenze (IT)
- National Institutes of Health (US)
- Boston University (US)
- Corresponding author
- Maggio, Marcello
- ORCID
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2010-10-12
- Volume
- 14
- Issue
- 1
- Pages
- 42-47
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- PMC
- PMC3142745
- OpenAlex
- W2107004527
- Cited by
- 38
- References
- 30
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 7
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ministero della Salute (263 MD 9164 13, ICS 110.1/RS97.71, N01-AG-916413, 263 MD 821336, N01-AG-821336, 263 MD 9164, 110.1|RS97.71)
- National Institutes of Health
- National Institute on Aging (N01AG-821336, N01[AG]916413)
- National Institute on Minority Health and Health Disparities (R01MD009164)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- hypogonadism, testosterone, older men, physical performance, grip strength, hemoglobin, Short Physical Performance Battery, muscle mass, walking speed, InCHIANTI cohort
- MeSH terms
- Age Factors, Aged, Aging, Androgens, Exercise Test, Health Status, Health Status Indicators, Hemoglobins, Humans, Hypogonadism, Inflammation, Italy, Male, Motor Activity, Reference Values, Task Performance and Analysis, Testosterone, Interleukin-6, Linear Models, Muscle, Skeletal, Muscle Strength, Men's Health
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