Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function
Open accessAbstract
Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.
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In men, the decline in C19 steroid production can be explained by simultaneous age-related reductions of both adrenal and testicular androgen biosynthesis.
“In men, the decline can be explained by simultaneous age-related reductions of both adrenal and testicular androgen biosynthesis (Beattie et al., 2015, Camacho et al., 2013, Golan et al., 2015, Labrie et al., 1997b).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Golan et al., 2015
A decline of androgens in men starting in the third decade of life can be observed as aging results in a gradual development of testicular failure due to a decreased number of Leydig cells and response to hypothalamic-pituitary signalling.
“A decline of androgens in men starting in the third decade of life can be observed as aging results in a gradual development of testicular failure due to a decreased number of Leydig cells and response to hypothalamic-pituitary signalling (Beattie et al., 2015, Golan et al., 2015).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Golan et al., 2015
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Hoai, B. N., Truong, T. Đ., Thắng, N. C., Pham, Q. M., & Nguyen, V. B. D. (2024) · The Aging Male · doi:10.1080/13685538.2024.2422379 · Cited by 3 · see citing works
Lifestyle in flux: urbanization, dietary shifts, and endocrine health in emerging adulthood
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Age-Related Testosterone Decline: Whom Do We Treat and Why?
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Pituitary Dysfunction in Systemic Disorders
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The complex interplay of sex steroids manifested by endocrine treatment of prostate cancer
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EVALUATION OF OXIDATIVE AND GONADAL AXIS PROFILE IN AGING MALES FROM PUNJAB-PAKISTAN
(2022) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2022/11.3.5978
AGE-RELATED CHANGES IN HYPOTHALAMIC PITUITARY GONADAL AXIS IN MALES OF CENTRAL PUNJAB
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Human Populations with Extreme Longevities
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Effects of chronic treadmill exercise on testosterone levels in males and females
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Endocrine Support for the Aesthetic Patient
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- Authors
- Golan, R., Scovell, J. M., & Ramasamy, R.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Baylor College of Medicine (US)
- Corresponding author
- Ramasamy, Ranjith
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2015-06-15
- Volume
- 18
- Issue
- 3
- Pages
- 201-204
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- PMC
- PMC4816459
- OpenAlex
- W1895814136
- Cited by
- 73
- References
- 37
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD073917‑01, K12HD073917)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- age-related testosterone decline, age-related hypogonadism, hypergonadotropic hypogonadism, secondary hypogonadism, testicular function, hypothalamic-pituitary-gonadal axis, androgen deficiency, testosterone replacement therapy, older men
- MeSH terms
- Aging, Humans, Hypogonadism, Hypothalamo-Hypophyseal System, Male, Testis, Testosterone, Hormone Replacement Therapy
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