Anti-inflammatory activity of essential oil from leaves of Myrciaria tenella and Calycorectes sellowianus
Open accessAbstract
The GC-MS analysis revealed that the leaf essential oils of Myrciaria tenella (DC.) Berg and Calycorectes sellowianus O. Berg (Myrtaceae) were composed of 34 and 37 compounds, respectively. The main constituents of M. tenella oil were beta-caryophyllene (25.1%), and spathulenol (9.7%), while for C. sellowianus were guaiol (13.1%) and beta-caryophyllene (8.6%). The anti-inflammatory effect of both essential oils was investigated in vitro and in vivo. Both oils reduced significantly (p < 0.005) the treated neutrophils chemotaxis with 93% and 91% inhibition for M. tenella and C. sellowianus, respectively. However, in the systemic treatment with the essential oils (50 mg/kg p.o.) only the M. tenella oil was able to significantly reduce the carrageenan-induced paw edema with a similar effect to that observed for indomethacin (10 mg/kg), the positive control.
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Carrageenan-induced mouse paw oedema is frequently used to determine anti-inflammatory activity of plant extracts and essential oils.
“Carrageenan-induced mouse paw oedema is frequently used to determine the anti-inflammatory activity of diverse bioactive compounds such as plant extracts and essential oils [87,88,89,90,91,92,93,94,95].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [92]
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Research works printed but not linked: 1
- Apel, MA (2001): Volatile Oils of species from Eugeniinae sub-tribe (Myrtaceae): chemical composition and antimicrobial and anti- inflammatory activities, PhD Thesis Porto Alegre. UFRGS, 256 p.
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · see citing works
- Authors
- Apel, M. A., Lima, M. E. L., Sobral, M., Young, M. C. M., Cordeiro, I., Schapoval, E. E. S., Henriques, A. T., & Moreno, P. R. H.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal de Minas Gerais (BR)
- Instituto de Botânica (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Moreno, Paulo Roberto H.
- ORCID
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2010-03-11
- Volume
- 48
- Issue
- 4
- Pages
- 433-438
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2125038303
- Cited by
- 42
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Myrtaceae, leaf essential oil, anti-inflammatory activity, β-caryophyllene, spathulenol, guaiol, neutrophil chemotaxis, carrageenan-induced paw edema, chemical composition
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Chemotaxis, Leukocyte, Edema, Male, Gas Chromatography-Mass Spectrometry, Neutrophils, Oils, Volatile, Rats, Wistar, Plant Leaves, Myrtaceae, Rats
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