Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing
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CONTEXT: Lipoic acid (LA) and hyperbaric oxygenation therapy (HBOT) improve chronic wound healing. OBJECTIVE: We compared the effects of LA or its enantiomer R-(+)-lipoic acid (RLA) on wound healing. MATERIALS AND METHODS: Groups LA + HBOT (L), RLA + HBOT (R) and placebo + HBOT (P). Lesion areas measured before treatment and on 20th and 40th day. The biopsies and plasma were harvested before treatment and on 7th and 14th (measurements of VEGF, vascular endothelial growth factor; EGF, epidermal growth factor, TNF-α and IL-6). RESULTS: Ulcers improved more on RLA. In both L and R groups, EGF and VEFG increased in time. RLA decreased IL-6 on T7 and T14, which did not happen with LA. TNF-α levels decreased on T14 in both LA and RLA. DISCUSSION: The improved wound healing is associated with increased EGF and VEGF and reduced plasma TNF-α and IL-6. CONCLUSION: RLA may be more effective than LA in improving chronic wound healing in patients undergoing HBO therapy.
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IL6 contributes to wound healing both via proinflammatory actions and by promoting cell migration.
“IL6 is important in wound healing, not only through proinflammatory effects but also by promoting cell migration (Ebihara, et al., 2011,Nasole, et al., 2014).”
From A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin (2016) · cites this paper as Nasole, et al., 2014
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A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin
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“IL6 is important in wound healing, not only through proinflammatory effects but also by promoting cell migration (Ebihara et al., 2011; Nasole et al., 2014).”
Background
- Authors
- Nasole, E., Nicoletti, C., Yang, Z.-J., Girelli, A., Rubini, A., Giuffreda, F., Di Tano, A., Camporesi, E., & Bosco, G.
- Affiliations
- Istituto Iperbarico SpA, Diving and Hyperbaric Medicine Unit in Villafranca VeronaItaly
- Diabetic Foot Unit, “Dr. Pederzoli” Hospital Peschiera G., VeronaItaly
- SUNY Upstate Medical University (US)
- University of Padua (IT)
- Department of Neuroimaging, Section of Physiology, University of Chieti ChietiItaly
- Tampa General Hospital (US)
- Corresponding author
- Rubini, Alessandro
- Venue
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2013-01-30
- Volume
- 29
- Issue
- 2
- Pages
- 297-302
- ISSN
- 1475-6366 (ISSN-L)
- 1475-6374
- OpenAlex
- W2028328834
- Cited by
- 39
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Enzyme Inhibition and Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- alpha-lipoic acid, hyperbaric oxygen therapy, chronic wounds, interleukin-6, TNF-α, epidermal growth factor, vascular endothelial growth factor, enantiomers, wound healing
- MeSH terms
- Aged, Aged, 80 and over, Antioxidants, Chronic Disease, Combined Modality Therapy, Double-Blind Method, Epidermal Growth Factor, Female, Humans, Hyperbaric Oxygenation, Thioctic Acid, Male, Middle Aged, Stereoisomerism, Tumor Necrosis Factor-alpha, Wound Healing, Interleukin-6, Diabetic Foot
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