Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.

Löndahl, Magnus; Katzman, Per; Nilsson, Anders; Hammarlund, Christer

doi:10.2337/dc09-1754

Cited by 441Diabetic Foot Ulcer Assessment and ManagementWound Healing and TreatmentsSkin Diseases and Diabetes

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.

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Löndahl, Magnus, Katzman, Per, Nilsson, Anders, Hammarlund, Christer·2010·Diabetes Care

DOI 10.2337/dc09-1754PMC PMC2858204

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Abstract

OBJECTIVE: Chronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS: The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study was a randomized, single-center, double-blinded, placebo-controlled clinical trial. The outcomes for the group receiving HBOT were compared with those of the group receiving treatment with hyperbaric air. Treatments were given in a multi-place hyperbaric chamber for 85-min daily (session duration 95 min), five days a week for eight weeks (40 treatment sessions). The study was performed in an ambulatory setting. RESULTS: Ninety-four patients with Wagner grade 2, 3, or 4 ulcers, which had been present for >3 months, were studied. In the intention-to-treat analysis, complete healing of the index ulcer was achieved in 37 patients at 1-year of follow-up: 25/48 (52%) in the HBOT group and 12/42 (29%) in the placebo group (P = 0.03). In a sub-analysis of those patients completing >35 HBOT sessions, healing of the index ulcer occurred in 23/38 (61%) in the HBOT group and 10/37 (27%) in the placebo group (P = 0.009). The frequency of adverse events was low. CONCLUSIONS: The HODFU study showed that adjunctive treatment with HBOT facilitates healing of chronic foot ulcers in selected patients with diabetes.

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Dressing selection based on wound characteristics promotes a moist environment conducive to tissue growth and epithelial migration.
“Dressing selection Based on wound characteristics, ie, location, inflammation, and amount of exudate Promote a moist environment conducive to tissue growth and epithelial migration.63,64”
From Diabetic Foot Ulcers (2023) · cites this paper as [63]
The Research Design and Methods section describes routine diabetic-foot care, and its End points subsection defines healing by epithelial regeneration. Neither passage addresses selecting dressings by wound characteristics or says that dressings create a moist environment promoting tissue growth and epithelial migration. Searches for dressing, moisture, exudate, and epithelial migration found no passage supporting that point; page numbers were unavailable in our copy. (LLM, conf=0.74)
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Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care 2010;33:998–1003
Löndahl, M. (2013)
Hyperbaric Oxygen Therapy as adjunctive treatment of chronic diabetic foot ulcers
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Role of hyperbaric oxygen therapy in the treatment of chronic ulcers of the foot in patients with type II diabetes mellitus
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Authors: Löndahl, M., Katzman, P., Nilsson, A., & Hammarlund, C.
Affiliations: Lund University (SE)
Department of Internal Medicine, Ängelholm Hospital, Ängelholm, Sweden;
Helsingborgs lasarett (SE)
Corresponding author: Löndahl, Magnus
ORCID: Löndahl, Magnus
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2010-05-01
Volume: 33
Issue: 5
Pages: 998-1003
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc09-1754
PMC: PMC2858204
OpenAlex: W2143723758
Cited by: 441
References: 28
Citations by year: 2026: 22 · 2025: 28 · 2024: 25 · 2023: 20 · 2022: 16 · 2021: 31 · 2020: 33 · 2019: 25 · 2018: 31 · 2017: 26 · 2016: 26 · 2015: 28 · 2014: 22 · 2013: 45 · 2012: 29
FWCI: 25.69
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 4137 d)
Locations: Diabetes Care (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: hyperbaric oxygen therapy, chronic diabetic foot ulcers, wound healing, hyperbaric air, Wagner grade, adjunctive therapy, diabetes mellitus, adverse events
MeSH terms: Adult, Aged, Aged, 80 and over, Air, Amputation, Surgical, Chronic Disease, Female, Follow-Up Studies, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Placebos, Wound Healing, Treatment Outcome, Diabetic Foot

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Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.

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