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Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia
Abstract
OBJECTIVES: The aim of this study was to investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia. A particular objective was the comparison of normal umbilical serum levels to preeclamptic values. MATERIALS AND METHODS: The study group consisted of 24 patients with third trimester singleton pregnancies complicated by preeclampsia (15 severe and 9 mild preeclampsia). The gestational age-matched 19 healthy pregnant women were compared by study group. Maternal and umbilical serum IL-6, IL-8, and TNF-alpha were calculated by using enzyme-linked immunosorbent assay. RESULTS: Significantly increased maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha were found in preeclamptic patient group in comparison with the control group. Maternal serum IL-8 and TNF-alpha concentration were significantly higher in patients with severe preeclampsia than in mild preeclampsia. Increased umbilical serum levels of IL-6 and IL-8 were found in severe preeclampsia than in mild preeclampsia. There were significantly higher levels of maternal serum IL-8 and TNF-alpha in patients with preeclampsia with IUGR than in patients with preeclampsia with normal fetal growth. CONCLUSION: Our findings suggest that increased concentrations of IL-6, IL-8, and TNF-alpha in the maternal and umbilical serum play a significant role in pathogenesis of preeclampsia. Alterations in maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha may also play role in preeclampsia complicated by intrauterine growth retardation. These associations may offer insight into the etiology and pathogenesis of preeclampsia.
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“Metformin also decreased the expression of vascular cell adhesion molecule 1 (VCAM1), expressed by endothelial cells that are dysfunctional or have been stimulated by incubation with tumor necrosis factor alpha (TNF-α), a cytokine increased in the circulation of patients with preeclampsia(190–195).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [194]
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Metadata
- Authors
- Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E.
- Affiliations
- Ondokuz Mayıs University (TR)
- Corresponding author
- Celik, Handan
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-05-04
- Volume
- 23
- Issue
- 8
- Pages
- 880-886
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2034857553
- Cited by
- 185
- References
- 31
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 15
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- preeclampsia, interleukin-6, interleukin-8, TNF-α, umbilical cord serum, maternal serum cytokines, fetal growth restriction, preeclampsia pathogenesis, third trimester
- MeSH terms
- Adult, Female, Fetal Blood, Humans, Pre-Eclampsia, Pregnancy, Tumor Necrosis Factor-alpha, Interleukin-6, Case-Control Studies, Interleukin-8, Young Adult
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