The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia
Abstract
OBJECTIVES: The aim of this study was to investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia. A particular objective was the comparison of normal umbilical serum levels to preeclamptic values. MATERIALS AND METHODS: The study group consisted of 24 patients with third trimester singleton pregnancies complicated by preeclampsia (15 severe and 9 mild preeclampsia). The gestational age-matched 19 healthy pregnant women were compared by study group. Maternal and umbilical serum IL-6, IL-8, and TNF-alpha were calculated by using enzyme-linked immunosorbent assay. RESULTS: Significantly increased maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha were found in preeclamptic patient group in comparison with the control group. Maternal serum IL-8 and TNF-alpha concentration were significantly higher in patients with severe preeclampsia than in mild preeclampsia. Increased umbilical serum levels of IL-6 and IL-8 were found in severe preeclampsia than in mild preeclampsia. There were significantly higher levels of maternal serum IL-8 and TNF-alpha in patients with preeclampsia with IUGR than in patients with preeclampsia with normal fetal growth. CONCLUSION: Our findings suggest that increased concentrations of IL-6, IL-8, and TNF-alpha in the maternal and umbilical serum play a significant role in pathogenesis of preeclampsia. Alterations in maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha may also play role in preeclampsia complicated by intrauterine growth retardation. These associations may offer insight into the etiology and pathogenesis of preeclampsia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Metformin also decreased the expression of vascular cell adhesion molecule 1 (VCAM1), expressed by endothelial cells that are dysfunctional or have been stimulated by incubation with tumor necrosis factor alpha (TNF-α), a cytokine increased in the circulation of patients with preeclampsia(190–195).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [194]
Citations
Cites
Latest Advances in Understanding Preeclampsia
Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607
Preeclampsia: An excessive maternal inflammatory response to pregnancy
Redman, C. W. G., Sacks, G. P., & Sargent, I. L. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70239-5 · Cited by 1,838
Li, A., Dubey, S., Varney, M. L., Davé, B. J., & Singh, R. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3369 · Cited by 1,324
Salcedo, R., Ponce, M. L., Young, H. A., Wasserman, K., Ward, J. M., Kleinman, H. K., Oppenheim, J. J., & Murphy, W. J. (2000) · Blood · doi:10.1182/blood.v96.1.34 · Cited by 860
Sacks, G. P., Studená, K., Sargent, I. L., & Redman, C. W. G. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70254-6 · Cited by 823
Roberts, J. M., & Gammill, H. S. (2005) · Hypertension · doi:10.1161/01.hyp.0000188408.49896.c5 · Cited by 693
Aderka, D., Le, J., & Vilček, J. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.11.3517 · Cited by 577
Multiple actions of interleukin 6 within a cytokine network
Wong, G., & Clark, S. C. (1988) · Immunology Today · doi:10.1016/0167-5699(88)91200-5 · Cited by 534
Varfolomeev, E. E., & Ashkenazi, A. (2004) · Cell · doi:10.1016/s0092-8674(04)00166-7 · Cited by 498
Inflammatory Cytokines Impair Endothelium-Dependent Dilatation in Human Veins In Vivo
Bhagat, K., & Vallance, P. J. (1997) · Circulation · doi:10.1161/01.cir.96.9.3042 · Cited by 409
Research works printed but not linked: 1
- Greer IA, 1994, Obstet Gynecol, 84, 937
Cited by
Sorted by citations
Schreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 445
Cotechini, T., Komisarenko, M., Sperou, A., Macdonald-Goodfellow, S. K., Adams, M. A., & Graham, C. H. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130295 · Cited by 343
Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia
Boeldt, D. S., & Bird, I. M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0340 · Cited by 360
The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia
Darmochwał-Kolarz, D., Kłudka-Sternik, M., Tabarkiewicz, J., Kolarz, B., Roliński, J., Leszczyńska‐Gorzelak, B., & Oleszczuk, J. (2012) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2012.01.006 · Cited by 260
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253
Metadata
- Authors
- Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E.
- Affiliations
- Ondokuz Mayıs University (TR)
- Corresponding author
- Celik, Handan
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-05-04
- Volume
- 23
- Issue
- 8
- Pages
- 880-886
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2034857553
- Cited by
- 185
- References
- 31
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 15
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- preeclampsia, interleukin-6, interleukin-8, TNF-α, umbilical cord serum, maternal serum cytokines, fetal growth restriction, preeclampsia pathogenesis, third trimester
- MeSH terms
- Adult, Female, Fetal Blood, Humans, Pre-Eclampsia, Pregnancy, Tumor Necrosis Factor-alpha, Interleukin-6, Case-Control Studies, Interleukin-8, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
