The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Patients with Chronic Pain After Abdominal Surgery Show Less Preoperative Endogenous Pain Inhibition and More Postoperative Hyperalgesia: A Pilot Study
Abstract
Chronic pain is common and undesirable after surgery. Progression from acute to chronic pain involves altered pain processing. The authors studied relationships between presence of chronic pain versus preoperative descending pain control (diffuse noxious inhibitory controls; DNICs) and postoperative persistence and spread of skin and deep tissue hyperalgesia (change in electric/pressure pain tolerance thresholds; ePTT/pPTT) up to 6 months postoperatively. In 20 patients undergoing elective major abdominal surgery under standardized anesthesia, we determined ePTT/pPTT (close to [abdomen] and distant from [leg] incision), eDNIC/pDNIC (change in ePTT/pPTT with cold pressor pain task; only preoperatively), and a 100 mm long pain visual analogue scale (VAS) (0 mm = no pain, 100 mm = worst pain imaginable), both at rest and on movement preoperatively, and 1 day and 1, 3, and 6 months postoperatively. Patients reporting chronic pain 6 months postoperatively had more abdominal and leg skin hyperalgesia over the postoperative period. More inhibitory preoperative eDNIC was associated with less late postoperative pain, without affecting skin hyperalgesia. More inhibitory pDNIC was linked to less postoperative leg deep tissue hyperalgesia, without affecting pain VAS. This pilot study for the first time links chronic pain after surgery, poorer preoperative inhibitory pain modulation (DNIC), and greater postoperative degree, persistence, and spread of hyperalgesia. If confirmed, these results support the potential clinical utility of perioperative pain processing testing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“(5) Alterations in pain processing are increasingly accepted to underlie chronic pain and its development, (5,14,21,22) hence improved insight into these is widely considered a prerequisite for more effective treatment approaches to pain.”
BackgroundCoderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90161-h · Cited by 1,966
Towards a theory of chronic pain
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.018 · Cited by 876
Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750 · cited 3×
“(9) Postoperative monitoring of the persistence and spread of hyperalgesia may permit patients at risk for development of chronic pain to be identified and treated.”
BackgroundInfluentialWidespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.032 · Cited by 634
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
Metz, A. E., Yau, H.-J., Centeno, M. V., Apkarian, A. V., & Martina, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809897106 · Cited by 407
Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371
Cut and thrust: antecedent surgery and trauma among patients attending a chronic pain clinic
Crombie, I. K., Davies, H. T. O., & Macrae, W. A. (1998) · Pain · doi:10.1016/s0304-3959(98)00038-4 · Cited by 351
Chronic pain after thoracic surgery: a follow‐up study
Perttunen, K., Tasmuth, T., & Kalso, E. (1999) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.1999.430513.x · Cited by 330
Edwards, R. R., Ness, T. J., Weigent, D. A., & Fillingim, R. B. (2003) · Pain · doi:10.1016/j.pain.2003.09.005 · Cited by 220
Cited by
Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N. B., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.2 · Cited by 2,058
Reliability of conditioned pain modulation: a systematic review
Kennedy, D. L., Kemp, H. I., Ridout, D., Yarnitsky, D., & Rice, A. S. C. (2016) · Pain · doi:10.1097/j.pain.0000000000000689 · Cited by 456
Pain modulation profile and pain therapy: Between pro- and antinociception
Yarnitsky, D., Granot, M., & Granovsky, Y. (2014) · Pain · doi:10.1016/j.pain.2013.11.005 · Cited by 297
Petersen, K. K., Arendt-Nielsen, L., Simonsen, O., Wilder-Smith, O., & Laursen, M. B. (2015) · Pain · doi:10.1016/j.pain.0000000000000022 · Cited by 269
Self-citationThe progression from acute to chronic pain
Lavand’homme, P. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32834a4f74 · Cited by 179
Metadata
- Authors
- Wilder-Smith, O. H., Schreyer, T., Scheffer, G. J., & Arendt-Nielsen, L.
- Venue
- Journal of Pain & Palliative Care Pharmacotherapy
- Publisher
- Informa UK Limited
- Published
- 2010-05
- Volume
- 24
- Issue
- 2
- Pages
- 119-128
- ISSN
- 1536-0288 (ISSN-L)
- 1536-0539
- OpenAlex
- W2160071391
- Cited by
- 177
- References
- 11
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Patients with Chronic Pain After Abdominal Surgery Show Less Preoperative Endogenous Pain Inhibition and More Postoperative Hyperalgesia: A Pilot Study. https://app.cochat.ai/papers/10.3109/15360281003706069
- The paper
- Wilder-Smith, O. H., Schreyer, T., Scheffer, G. J., & Arendt-Nielsen, L. (2010). Patients with Chronic Pain After Abdominal Surgery Show Less Preoperative Endogenous Pain Inhibition and More Postoperative Hyperalgesia: A Pilot Study. Journal of Pain & Palliative Care Pharmacotherapy. https://doi.org/10.3109/15360281003706069
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
