The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells
Abstract
The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering of colonic adenocarcinoma HT29 and gastric adenocarcinomas MKN7 and MKN74 cells. Likewise, EGF induced scattering of HT29 and MKN7 cells. These cells expressed E-cadherin, which was concentrated at cell-cell contact sites. When the scattering of these cells was induced by HGF/SF or EGF, the E-cadherin concentration at cell-cell boundaries tended to decrease. Immunoblotting analyses, however, demonstrated that these growth factor treatments did not alter the expression of E-cadherin and E-cadherin-associated proteins, alpha- and beta-catenin and plakoglobin. beta-Catenin, plakoglobin and an unidentified 115-kDa molecule associated with E-cadherin were found to be phosphorylated at tyrosine residues, and these phosphorylations were enhanced by the growth factor treatments. These results suggest that HGF/SF and EGF may modulate the function of the cadherin-catenin system via tyrosine phosphorylation of cadherin-associated proteins.
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Cites
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Cited by
Regulation of Cadherin Adhesive Activity
Gumbiner, B. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.399 · Cited by 787
Scatter-factor and semaphorin receptors: cell signalling for invasive growth
Trusolino, L., & Comoglio, P. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc779 · Cited by 745
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656
Cheng, C. Y., & Mruk, D. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00009.2002 · Cited by 567
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways
Barth, A. I., Näthke, I. S., & Nelson, W. J. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80122-6 · Cited by 537
Metadata
- Authors
- Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., Oku, N., Miyazawa, K., Kitanfura, N., Takeichi, M., & Ito, F.
- Venue
- Cell Adhesion and Communication
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 1
- Issue
- 4
- Pages
- 295-305
- ISSN
- 1023-7046 (ISSN-L)
- 1029-2314
- OpenAlex
- W2070715920
- Cited by
- 414
- References
- 41
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells. https://app.cochat.ai/papers/10.3109/15419069409097261
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- Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., Oku, N., Miyazawa, K., Kitanfura, N., Takeichi, M., & Ito, F. (1994). Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells. Cell Adhesion and Communication. https://doi.org/10.3109/15419069409097261
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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