The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates
Open accessAbstract
Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.
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“A number of studies have demonstrated that elevated concentrations of PFAS can lead to immunosuppression, increased severity of infections, and decreased response to vaccines”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Kielsen et al., 2016
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Citations
Cites
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Metadata
- Authors
- Kielsen, K., Shamim, Z., Ryder, L. P., Nielsen, F., Grandjean, P., Budtz-Jørgensen, E., & Heilmann, C.
- Affiliations
- Institute for Inflammation Research, Department of Rheumatology,
- Copenhagen University Hospital (DK)
- University of Southern Denmark (DK)
- Harvard University (US)
- Department of Biostatistics, School of Public Health, University of Copenhagen, Copenhagen, Denmark
- Corresponding author
- Heilmann, Carsten
- Venue
- Journal of Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2015-07-16
- Volume
- 13
- Issue
- 2
- Pages
- 270-273
- ISSN
- 1547-6901 (ISSN-L)
- 1547-691X
- PMC
- PMC4739630
- OpenAlex
- W1751780479
- Cited by
- 116
- References
- 10
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 17 · 2023: 24 · 2022: 12 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 5
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Immunotoxicology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Institutes of Health (ES012199)
- National Institute of Environmental Health Sciences (R01ES012199, ES012199)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- immunosuppression, booster vaccination, tetanus toxoid, diphtheria toxoid, antibody response, humoral immune response, serum PFAS concentrations, healthy adults
- MeSH terms
- Adult, Antibodies, Bacterial, Antibody Formation, Environmental Exposure, Female, Humans, Hydrocarbons, Fluorinated, Immunization, Secondary, Male, Diphtheria-Tetanus Vaccine
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