Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian Subjects
Open accessAbstract
Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of MDD. We hypothesise that variation in SLC30A3 (rs11126936) SNP increases risk of MDD. We recruited 300 MDD cases and 300 controls, matched in the ratio of 1:1 by age, gender and ethnicity. PCR-restriction fragment length polymorphism analysis was used in DNA genotyping, validated by sequencing 10% of samples. Deviation from the Hardy-Weinberg equilibrium was tested using the chi-square test. Conditional logistic regression was used to estimate adjusted odds ratios, controlling for age, gender, ethnicity, occupation and family monthly income. Genotypes G/G and G/T showed two times greater odds of developing MDD compared to variant genotype T/T (OR=1.983, 95% CI=1.031-3.815; p=0.040 and OR=2.232, 95% CI=1.100-4.533; p=0.026 respectively). Carriers of genotypes G/G and G/T of the SNP rs11126936 in SLC30A3 are associated with increased risk of MDD.
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SNPs of VDR and ZnT3 genes are associated with MDD.
“findings by Kuningas et al. (2009) [32] and Lye et al. [33] that single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and zinc transporter-3 (SLC30A3) genes were respectively associated with MDD”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [33]
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Sorted by citations
Predictors of recurrence of major depressive disorder
Lye, M.-S., Tey, Y.-Y., Tor, Y.-S., Shahabudin, A. F., Ibrahim, N., Ling, K.-H., Stanslas, J., Loh, S.-P., Rosli, R., Lokman, K. A., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0230363 · Cited by 43 · see citing works
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- Authors
- Lye, M. S., Shahbudin, A.-F., Tey, Y. Y., Tor, Y. S., Ling, K. H., Ibrahim, N., Stanslas, J., Loh, S. P., & Rosli, R.
- Affiliations
- Universiti Putra Malaysia (MY)
- ORCID
- Venue
- Neuroscience Research Notes
- Publisher
- Neurotak Publishing
- Published
- 2019-09-13
- Volume
- 2
- Issue
- 3
- Pages
- 20-28
- ISSN
- 2576-828X (ISSN-L)
- OpenAlex
- W2973045535
- Cited by
- 4
- References
- 34
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience Research Notes (publishedVersion, cc-by-nc)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Funders
- Universiti Putra Malaysia (GP-IPB/2013/9415700)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, ZnT3, single nucleotide polymorphisms, genetic susceptibility, glutamatergic synapses, Asian populations
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