Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
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BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin found in abundance in brain regions such as the hippocampus, cortex, cerebellum and basal forebrain. It has been associated with the risk of susceptibility to major depressive disorder (MDD). This study aimed to determine the association of three BDNF variants (rs6265, rs1048218 and rs1048220) with Malaysian MDD patients. METHODS: The correlation of these variants to the plasma BDNF level among Malaysian MDD patients was assessed. A total of 300 cases and 300 matched controls recruited from four public hospitals within the Klang Valley of Selangor State, Malaysia and matched for age, sex and ethnicity were screened for BDNF rs6265, rs1048218 and rs1048220 using high resolution melting (HRM). FINDINGS: BDNF rs1048218 and BDNF rs1048220 were monomorphic and were excluded from further analysis. The distribution of the alleles and genotypes for BDNF rs6265 was in Hardy-Weinberg equilibrium for the controls (p = 0.13) but was in Hardy Weinberg disequilibrium for the cases (p = 0.011). Findings from this study indicated that having BDNF rs6265 in the Malaysian population increase the odds of developing MDD by 2.05 folds (95% CI = 1.48-3.65). Plasma from 206 cases and 206 controls were randomly selected to measure the BDNF level using enzyme-linked immunosorbent assay (ELISA). A significant decrease in the plasma BDNF level of the cases as compared to controls (p<0.0001) was observed. However, there was no evidence of the effect of the rs6265 genotypes on the BDNF level indicating a possible role of other factors in modulating the BDNF level that warrants further investigation. CONCLUSION: The study indicated that having the BDNF rs6265 allele (A) increase the risk of developing MDD in the Malaysian population suggesting a possible role of BDNF in the etiology of the disorder.
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A study reported a link between the BDNF rs6265 allele (A) and major depressive disorder.
“a study reported a link between the BDNF rs6265 allele (A) and major depressive disorder [117].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [117]
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BDNF rs962369 Is Associated with Major Depressive Disorder
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- Authors
- Aldoghachi, A. F., Tor, Y. S., Redzun, S. Z., Lokman, K. A. B., Razaq, N. A. A., Shahbudin, A. F., Badamasi, I. M., Cheah, P.-S., Stanslas, J., Veerakumarasivam, A., Rosli, R., Ibrahim, N., Lye, M. S., & Ling, K.-H.
- Affiliations
- Universiti Putra Malaysia (MY)
- Sunway University (MY)
- Corresponding author
- Ling, King-Hwa
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-01-24
- Volume
- 14
- Issue
- 1
- Pages
- e0211241
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6345459
- OpenAlex
- W2915044328
- Cited by
- 54
- References
- 58
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Universiti Putra Malaysia (GP-IPB/2013/9415701)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, major depressive disorder, single nucleotide polymorphisms, BDNF Val66Met polymorphism, plasma BDNF levels, genetic susceptibility, Malaysian population, genetic association
- MeSH terms
- Adolescent, Adult, Aged, Alleles, Depressive Disorder, Major, Major Depressive Disorder, Female, Genetic Testing, Genotype, Humans, Malaysia, Male, Middle Aged, Case-Control Studies, Brain-Derived Neurotrophic Factor, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Young Adult
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