Oxidized low-density lipoprotein as a biomarker of in vivo oxidative stress: From atherosclerosis to periodontitis
Open accessAbstract
Oxidized low-density lipoprotein is known as an important factor in the development of atherosclerosis. The introduction of a sensitive procedure for the determination of oxidized low-density lipoprotein in human circulating plasma using a monoclonal antibody recognizing oxidized phosphatidylcholines has opened new fields of research based on in vivo oxidized low-density lipoprotein. The plasma oxidized low-density lipoprotein levels are significantly elevated in patients with acute myocardial infarction, cerebral infarction or chronic renal failure accompanied by hemodialysis. It was found that the plasma oxidized low-density lipoprotein level increased prior to aortic atherosclerotic lesion enlargement in apolipoprotein E-knockout mice. Recent studies have pointed out that oxidized low-density lipoprotein is transferrable between vessel wall tissue and the circulation, so it is a reasonable hypothesis that plasma oxidized low-density lipoprotein levels reflect the oxidative status at local sites of atherogenesis. Oxidized low-density lipoprotein measurement has been applied to human gingival crevicular fluids, which can be collected easily and safely, and relatively high levels of oxidized low-density lipoprotein were shown to be present. These findings, together with recent clinical follow-up studies, suggest that oxidized low-density lipoprotein is a predictive biomarker of a variety of diseases related to oxidative stress. This review summarizes the current understanding of in vivo oxidized low-density lipoprotein and its potential significance as a biomarker of disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased oxidative stress promotes the conversion of low-density lipoprotein (LDL) cholesterol to the more atherogenic oxidized LDL form (oxLDL).
“increased oxidative stress has been found to promote the conversion of harmful low-density lipoprotein (LDL) cholesterol to the more atherogenic oxidized LDL form (oxLDL) [148,149].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works
Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626 · see citing works
Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513 · see citing works
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326 · see citing works
Identification of Periodontal Pathogens in Atheromatous Plaques
Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M., & Genco, R. J. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1554 · Cited by 1,125 · see citing works
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Kodama, T., Freeman, M. W., Rohrer, L., Zabrecky, J. R., Matsudaira, P. T., & Krieger, M. (1990) · Nature · doi:10.1038/343531a0 · Cited by 1,039 · see citing works
Ehara, S., Ueda, M., Naruko, T., Haze, K., Itoh, A., Otsuka, M., Komatsu, R., Matsuo, T., Itabe, H., Takano, T., et al. (2001) · Circulation · doi:10.1161/01.cir.103.15.1955 · Cited by 780 · see citing works
Bahekar, A., Singh, S., Saha, S. A., Molnár, J., & Arora, R. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.037 · Cited by 699 · see citing works
Atherosclerosis in the Apolipoprotein E–Deficient Mouse
Meir, K. S., & Leitersdorf, E. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000128849.12617.f4 · Cited by 498 · see citing works
Li, L., Messas, E., Júnior, E. L. B., Levine, R. A., & Amar, S. (2002) · Circulation · doi:10.1161/hc0702.104178 · Cited by 424 · see citing works
Li, D., & Mehta, J. L. (2000) · Circulation · doi:10.1161/01.cir.101.25.2889 · Cited by 421 · see citing works
Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability
Nishi, K., Itabe, H., Uno, M., Kitazato, K. T., Horiguchi, H., Shinno, K., & Nagahiro, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000033829.14012.18 · Cited by 409 · see citing works
Park, Y. M., Febbraio, M., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35535 · Cited by 407 · see citing works
Lalla, E., Lamster, I. B., Hofmann, M. A., Bucciarelli, L. G., Jerud, A. P., Tucker, S., Lu, Y., Papapanou, P. N., & Schmidt, A. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000082462.26258.fe · Cited by 384 · see citing works
Tsimikas, S., Bergmark, C., Beyer, R. W., Patel, R., Pattison, J., Miller, E. R., Juliano, J., & Witztum, J. L. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02769-9 · Cited by 348 · see citing works
Dietrich, T., Jiménez, M. C., Krall, E. A., Vokonas, P., & García, R. I. (2008) · Circulation · doi:10.1161/circulationaha.107.711507 · Cited by 294 · see citing works
Tsimikas, S., Lau, H. K. F., Han, K., Shortal, B. P., Miller, E. R., Segev, A., Curtiss, L. K., Witztum, J. L., & Strauss, B. H. (2004) · Circulation · doi:10.1161/01.cir.0000130844.01174.55 · Cited by 285 · see citing works
Itabe, H., Takeshima, E., Iwasaki, H., Kimura, J., Yoshida, Y., Imanaka, T., & Takano, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36602-4 · Cited by 282 · see citing works
Miller, Y. I., Viriyakosol, S., Worrall, D. S., Boullier, A., Butler, S. S., & Witztum, J. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000159891.73193.31 · Cited by 279 · see citing works
Sensitive detection of oxidatively modified low density lipoprotein using a monoclonal antibody.
Itabe, H., Yamamoto, H., Imanaka, T., SHIMAMURA, K., Uchiyama, H., Kimura, J., Sanaka, T., Hata, Y., & Takano, T. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37634-3 · Cited by 277 · see citing works
Origin and function of the cellular components in gingival crevice fluid
Delima, A. J., & Dyke, T. E. V. (2003) · Periodontology 2000 · doi:10.1034/j.1600-0757.2003.03105.x · Cited by 258 · see citing works
Greaves, D. R., & Gordon, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400011-jlr200 · Cited by 211 · see citing works
Spiteller, G. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.013 · Cited by 187 · see citing works
Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells
Sanson, M., Augè, N., Vindis, C., Muller, C., Bandô, Y., Thiers, J., Marachet, M.-A., Žarković, K., Sawa, Y., Salvayre, R., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.183749 · Cited by 179 · see citing works
Holvoet, P., Donck, J., Landeloos, M., Brouwers, E., Luijtens, K., Arnout, J., Lesaffre, E. M. E. H., Vanrenterghem, Y. F. C., & Collen, D. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650639 · Cited by 177 · see citing works
Wiesner, P., Choi, S., Almazan, F., Benner, C. W., Huang, W. J. M., Diehl, C. J., Gonen, A., Butler, S. S., Witztum, J. L., Glass, C. K., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.218420 · Cited by 174 · see citing works
Inoue, M., Itoh, H., Tanaka, T., Chun, T., Doi, K., Fukunaga, Y., Sawada, N., Yamshita, J., Masatsugu, K., Saito, T., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.560 · Cited by 159 · see citing works
Lipoprotein oxidation: mechanistic aspects, methodological approaches and clinical relevance.
Stocker, R. (1994) · PubMed · Cited by 151 · see citing works
Oxidized LDL Stimulates Mitogen-Activated Protein Kinases in Smooth Muscle Cells and Macrophages
Kusuhara, M., Chait, A., Cader, A. A., & Berk, B. C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.141 · Cited by 151 · see citing works
Sata, M., & Walsh, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33103 · Cited by 149 · see citing works
Oxidized Low-density Lipoproteins: What Is Understood and What Remains to Be Clarified.
Itabe, H. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1 · Cited by 148 · see citing works
Measurement of Plasma Oxidized Low-Density Lipoprotein and its Clinical Implications
Itabe, H., & Ueda, M. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14.1 · Cited by 147 · see citing works
Stocker, R. (1994) · Current Opinion in Lipidology · doi:10.1097/00041433-199412000-00005 · Cited by 129 · see citing works
Oxidized Phosphatidylcholines That Modify Proteins
Itabe, H., Yamamoto, H., Suzuki, M., Kawai, Y., Nakagawa, Y., Suzuki, A., Imanaka, T., & Takano, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33208 · Cited by 128 · see citing works
Suzuki, M., Kamei, M., Itabe, H., Yoneda, K., Bando, H., Kume, N., & Tano, Y. (2007) · PubMed Central · Cited by 127 · see citing works
Augè, N., Andrieu‐Abadie, N., Nègre‐Salvayre, A., Thiers, J., Levade, T., & Salvayre, R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19251 · Cited by 118 · see citing works
Raised plasma oxidised LDL in acute cerebral infarction
Uno, M. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.3.312 · Cited by 114 · see citing works
The precursors of coronary atherosclerotic plaques in subjects up to 40 years old
Velican, C., & VELICAN, D. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90091-x · Cited by 109 · see citing works
Holvoet, P., Cleemput, J. V., Collen, D., & Vanhaecke, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.698 · Cited by 105 · see citing works
Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS.
Pisano, E., Cabras, T., Montaldo, C., Piras, V., Inzitari, R., Olmi, C., Castagnola, M., & Messana, I. (2005) · European Journal of Oral Sciences · doi:10.1111/j.1600-0722.2005.00246.x · Cited by 95 · see citing works
Naruko, T., Ueda, M., Ehara, S., Itoh, A., Haze, K., Shirai, N., Ikura, Y., Ohsawa, M., Itabe, H., 小林, 芳., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000209886.31510.7f · Cited by 85 · see citing works
Tsimikas, S., Aikawa, M., Miller, F. J., Miller, E. R., Torzewski, M., Lentz, S. R., Bergmark, C., Heistad, D. D., Libby, P., & Witztum, J. L. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251501.86410.03 · Cited by 82 · see citing works
Kato, R., Mori, C., Kitazato, K. T., Arata, S., Obama, T., Mori, M., Takahashi, K., Aiuchi, T., Takano, T., & Itabe, H. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164723 · Cited by 82 · see citing works
Lehr, H., Hübner, C., Finckh, B., Angermüller, S., Nölte, D., Beisiegel†, U., Kohlschütter, A., & Meßmer, K. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115309 · Cited by 79 · see citing works
Lougheed, M., Moore, E. D. W., Scriven, D. R. L., & Steinbrecher, U. P. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1881 · Cited by 73 · see citing works
Taketa, K., Matsumura, T., Yano, M., Ishii, N., Senokuchi, T., Motoshima, H., Murata, Y., Kim‐Mitsuyama, S., Kawada, T., Itabe, H., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m703318200 · Cited by 60 · see citing works
Hamilton, T. A., Major, J. A., & Chisolm, G. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117887 · Cited by 60 · see citing works
LOX-1 and inflammation: a new mechanism for renal injury in obesity and diabetes
Kelly, K. J., Wu, P., Patterson, C. E., Temm, C. J., & Dominguez, J. H. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00396.2007 · Cited by 60 · see citing works
Ishii, H., Kizaki, K., Horie, S., & Kazama, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8458 · Cited by 55 · see citing works
Fang, J. C.-T., Kinlay, S., Behrendt, D., Hikita, H., Witztum, J. L., Selwyn, A. P., & Ganz, P. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040854.47020.44 · Cited by 52 · see citing works
Higashi, Y., Peng, T., Du, J., Sukhanov, S., Li, Y., Itabe, H., Parthasarathy, S., & Delafontaine, P. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400478-jlr200 · Cited by 45 · see citing works
Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T., & Hamanishi, C. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.07.010 · Cited by 44 · see citing works
Itabe, H., Suzuki, K., Tsukamoto, Y., Komatsu, R., Ueda, M., Mori, M., Higashi, Y., & Takano, T. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00098-6 · Cited by 42 · see citing works
Tanigawa, H., Miura, S.-I., Matsuo, Y., Fujino, M., Sawamura, T., & Saku, K. (2006) · Hypertension · doi:10.1161/01.hyp.0000229825.98545.5e · Cited by 33 · see citing works
Wu, C., Wang, S., Kuan, I., Tseng, W., Chen, M.-F., Wu, J., & Chen, Y. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22144 · Cited by 32 · see citing works
Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients
Sakiyama, Y., Kato, R., Inoue, S., Suzuki, K., Itabe, H., & Yamamoto, M. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2009.01226.x · Cited by 32 · see citing works
Nagahama, Y., Obama, T., Usui, M., Kanazawa, Y., Iwamoto, S., Suzuki, K., Miyazaki, A., Yamaguchi, T., Yamamoto, M., & Itabe, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.002 · Cited by 28 · see citing works
The role of CD36 in peripheral nerve remyelination after crush injury
Eto, M., Yoshikawa, H., Fujimura, H., Naba, I., Sumi‐Akamaru, H., TAKAYASU, S., Itabe, H., & Sakoda, S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02711.x · Cited by 27 · see citing works
Itabe, H., Jimi, S., Kamimura, S., Suzuki, K., Uesugi, N., Imanaka, T., Shijo, H., & Takano, T. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00069-0 · Cited by 22 · see citing works
Kimura, J., Nakagami, K., Amanuma, K., Ohkuma, S., Yoshida, Y., & Takano, T. (1987) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00713521 · Cited by 21 · see citing works
Suzuki, K., Sakiyama, Y., Usui, M., Obama, T., Kato, R., Itabe, H., & Yamamoto, M. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2009.01263.x · Cited by 21 · see citing works
Braun, S., Ndrepepa, G., von Beckerath, N., Mehilli, J., Gorchakova, O., Vogt, W., Schömig, A., & Kastrati, A. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.10.008 · Cited by 20 · see citing works
Mori, M., Itabe, H., Takatoku, K., Shima, K., Inoue, J., Nishiura, M., Takahashi, H., Ohtake, H., Sato, R., Higashi, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24828 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
Katerji, M., Filippova, M., & Duerksen-Hughes, P. J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1279250 · Cited by 435 · see citing works
Biomarkers of lipid peroxidation in clinical material
Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297 · see citing works
Menzel, A., Samouda, H., Dohet, F., Loap, S., Ellulu, M. S., & Bohn, T. (2021) · Antioxidants · doi:10.3390/antiox10030414 · Cited by 222 · see citing works
Inflammatory biomarkers for predicting cardiovascular disease
Stoner, L. R., Lucero, A. A., Palmer, B. R., Jones, L. M., Young, J. M., & Faulkner, J. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.05.070 · Cited by 196 · see citing works
Bohn, T. (2019) · Antioxidants · doi:10.3390/antiox8060179 · Cited by 181 · see citing works
Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China
Lin, Z., Chen, R., Jiang, Y., Xia, Y., Niu, Y., Wang, C., Liu, C., Chen, C., Ge, Y., Wang, W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.093 · Cited by 125 · see citing works
Wang, X., Wang, F., You, S., Cao, Y., Cao, L.-D., Han, Q., Liu, C., & Hu, L. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.010 · Cited by 109 · see citing works
Eo, H., Jeon, Y., Lee, M., & Lim, Y. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf502830b · Cited by 96 · see citing works
Effect of Natural Food Antioxidants against LDL and DNA Oxidative Changes
Kiokias, S. N., Proestos, C., & Oreopoulou, V. (2018) · Antioxidants · doi:10.3390/antiox7100133 · Cited by 94 · see citing works
Zhang, X., Qin, Y., Wan, X., Liu, H., Lv, C., Ruan, W., He, L., Lü, L., & Guo, X. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02727-3 · Cited by 75 · see citing works
Hernández-Baixauli, J., Quesada‐Vázquez, S., Mariné-Casadó, R., Cardoso, K. G., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Baselga‐Escudero, L. (2020) · Nutrients · doi:10.3390/nu12030806 · Cited by 73 · see citing works
Mota, J. C., Almeida, P. P., Freitas, M. Q., Stockler‐Pinto, M. B., & Guimarães, J. T. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134351 · Cited by 66 · see citing works
Cao, L., Zhang, Z., Li, Y., Zhao, P., & Chen, Y. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.04.042 · Cited by 65 · see citing works
Wu, S., Yang, D., Wei, H., Wang, B., Huang, J., Li, H., Shima, M., Deng, F., & Guo, X. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.04.096 · Cited by 63 · see citing works
Derivatization Methods for LC–MS Analysis of Endogenous Compounds
Zhu, Y., Deng, P., & Zhong, D. (2015) · Bioanalysis · doi:10.4155/bio.15.183 · Cited by 63 · see citing works
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae
Kim, C. H., & Leitch, H. A. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103367 · Cited by 54 · see citing works
Extracellular-vesicle containing miRNA-503-5p released by macrophages contributes to atherosclerosis
Wang, Y., Xu, Z., Wang, X., Zheng, J., Peng, L., Zhou, Y., Song, Y., & Lu, Z. (2021) · Aging · doi:10.18632/aging.103855 · Cited by 50 · see citing works
Zhang, S., Guo, C., Chen, Z., Zhang, P., Li, J., & Li, Y. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.02.020 · Cited by 49 · see citing works
RetractedMa, Y., Huang, Z., Zhou, Z., He, X.-Y., Wang, Y., Meng, C., Huang, G., & Fang, N. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.412 · Cited by 47 · see citing works
Hinterwirth, H. H., Stübiger, G., Lindner, W. F., & Lämmerhofer, M. (2013) · Analytical Chemistry · doi:10.1021/ac401778f · Cited by 46 · see citing works
Heritability of Biomarkers of Oxidized Lipoproteins
Rao, F., Schork, A. J., Maihofer, A. X., Nievergelt, C. M., Marcovina, S. M., Miller, E. R., Witztum, J. L., O’Connor, D. T., & Tsimikas, S. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305306 · Cited by 45 · see citing works
Wang, Q., Wang, Y., Lehto, K., Pedersen, N. L., Williams, D. M., & Hägg, S. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.007 · Cited by 42 · see citing works
Otahal, A., Kuten-Pella, O., Kramer, K., Neubauer, M., Lacza, Z., Nehrer, S., & Luna, A. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-84234-5 · Cited by 41 · see citing works
Babu, K. A., Sen, P., & Angayarkanni, N. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216899 · Cited by 39 · see citing works
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway
Lin, Y., Xie, Y., Hao, Z., Bi, H.-L., Liu, Y., Yang, X., & Xia, Y. (2021) · Journal of Immunology Research · doi:10.1155/2021/5151168 · Cited by 36 · see citing works
Oxidation-specific epitopes as targets for biotheranostic applications in humans
Miller, Y. I., & Tsimikas, S. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328364e85a · Cited by 34 · see citing works
Zhang, Q., Yong-shun, A., Dong, H., Wang, J., & Xu, L. (2018) · IUBMB Life · doi:10.1002/iub.1966 · Cited by 34 · see citing works
Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases
Zhang, H., Du, J., Huang, Y., Tang, C., & Jin, H. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0075 · Cited by 34 · see citing works
Wu, S., Yang, D., Pan, L., Shan, J., Li, H., Wei, H., Wang, B., Huang, J., Baccarelli, A., Shima, M., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.02.036 · Cited by 31 · see citing works
Khongwichit, S., Swangphon, P., Nanakorn, N., Nualla‐ong, A., Choowongkomon, K., Lieberzeit, P. A., & Chunta, S. (2022) · Talanta · doi:10.1016/j.talanta.2022.124199 · Cited by 31 · see citing works
Zhou, Y., Cao, X., Liu, Z., Cao, Y., Liu, C., Zhang, Y., & Xie, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146777 · Cited by 31 · see citing works
Influenza virus and atherosclerosis
Peretz, A., Azrad, M., & Blum, A. (2018) · QJM · doi:10.1093/qjmed/hcy305 · Cited by 30 · see citing works
Fentoğlu, Ö., Bulut, M. T., Doğan, B., Kırzıoğlu, F. Y., & Doğan, E. S. K. (2020) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2020.50.3.135 · Cited by 28 · see citing works
Atherogenic cholesterol-rich diet and periodontal disease
Macri, E. V., Lifshitz, F., Ramos, C., Orzuza, R., Costa, O., Zago, V., Boyer, P. M., & Friedman, S. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.03.006 · Cited by 27 · see citing works
Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish
Chen, Z., Zang, L., Wu, Y., Nakayama, H., Shimada, Y., Shrestha, R., Zhao, Y., Miura, Y., Chiba, H., Hui, S., et al. (2018) · Analytical Sciences · doi:10.2116/analsci.18p281 · Cited by 25 · see citing works
Okobi, O. E., Odoma, V. A., Okunromade, O., Louise-Oluwasanmi, O., Itua, B., Ndubuisi, C., Ogbeifun, O. E., Nwatamole, B. C., Elimihele, T. A., Adekunle, J. O., et al. (2023) · Cureus · doi:10.7759/cureus.41189 · Cited by 24 · see citing works
Haller, E., Stübiger, G., Lafitte, D., Lindner, W. F., & Lämmerhofer, M. (2014) · Analytical Chemistry · doi:10.1021/ac502855n · Cited by 23 · see citing works
Itabe, H., Kato, R., Sawada, N., Obama, T., & Yamamoto, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180307114855 · Cited by 23 · see citing works
Köse, O., Arabacı, T., Yemenoğlu, H., Özkanlar, S., Kurt, N., Gümüşsoy, İ., Gedikli, S., & Kara, A. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12428 · Cited by 22 · see citing works
Dawodu, D., Patecki, M., Dumler, I., Haller, H. G., & Kiyan, Y. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04735-5 · Cited by 21 · see citing works
LncRNA MIAT Mediates ox-LDL-Induced Endothelial Cell Injury Via miR-206/RAB22A Axis
Gao, Y., Yue, J., & Huang, Z. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.02.029 · Cited by 20 · see citing works
Association between peri‐implantitis and cardiovascular diseases: A case‐control study
Wang, I., Ou, A., Johnston, J., Giannobile, W. V., Yang, B., Fenno, J. C., & Wang, H. (2021) · Journal of Periodontology · doi:10.1002/jper.21-0418 · Cited by 22 · see citing works
Nagai, N., Izumi‐Nagai, K., Suzuki, M., Shinoda, H., Koto, T., Uchida, A., Mochimaru, H., Tomita, Y., Miyake, S., Kobayashi, S., et al. (2014) · Retina · doi:10.1097/iae.0000000000000382 · Cited by 20 · see citing works
Górski, B., Nargiełło, E., Opolski, G., Ganowicz, E., & Górska, R. (2016) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/62937 · Cited by 19 · see citing works
Liu, L., Cui, H., & Xu, Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00494 · Cited by 19 · see citing works
Baş, M., & Pabuçcuoğlu, A. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2007004 · Cited by 19 · see citing works
Feriani, A., Hachani, R., Tir, M., Ghazouani, L., Mufti, A., Borgi, M. A., & Allagui, M. S. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3771-7 · Cited by 18 · see citing works
Effect of Vitamin D3 on Monocyte Chemoattractant Protein 1 Production in Monocytes and Macrophages.
Wang, Y.-C., Hsieh, C., Kuo, H., Tsai, M.-K., Yang, S., Kuo, C., Lee, M., & Hung, C. (2014) · Europe PMC (PubMed Central) · Cited by 17 · see citing works
Jorgensen, J. M., Yang, Z., Lönnerdal, B. L., Chantry, C. J., & Dewey, K. G. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12394 · Cited by 17 · see citing works
Oxidized low-density lipoprotein predicts recurrent stroke in patients with minor stroke or TIA
Wang, A., Xu, J., Chen, G., Wang, D., Johnston, S. C., Meng, X., Lin, J., Li, H., Cao, Y., Zhang, N., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006118 · Cited by 15 · see citing works
Suo, J., Zhao, L., Wang, J., Zhu, Z., Zhang, H., & Gao, R. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24166 · Cited by 15 · see citing works
Chan, K. W., Ismail, M., Norhaizan, M. E., Alitheen, N. B., Imam, M. U., Ooi, D. J., & Khong, N. M. H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6742571 · Cited by 15 · see citing works
Kambayashi, Y., Takekoshi, S., Tanino, Y., Watanabe, K.-I., Nakano, M., Hitomi, Y., Takigawa, T., Ogino, K., & Yamamoto, Y. (2007) · Journal of clinical biochemistry and nutrition · doi:10.3164/jcbn.2007009 · Cited by 14 · see citing works
Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress
Master, E. L., Ahn, S. J., & Levitan, I. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.08.006 · Cited by 14 · see citing works
Lundberg, A. K., Chung, R. W. S., Zeijlon, L., Fernström, G., & Jonasson, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02906-2 · Cited by 14 · see citing works
Electrochemical approaches based on micro- and nanomaterials for diagnosing oxidative stress
Jamshidi, M., Walcarius, A., Thangamuthu, M., Mehrgardi, M. A., & Ranjbar, A. (2023) · Microchimica Acta · doi:10.1007/s00604-023-05681-7 · Cited by 13 · see citing works
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats
Antona, M. E., Ramos, C., Stranges, A., Monteiro, A. F., Chaves, M. M. G., Mandalunis, P., Zago, V., Friedman, S., & Macri, E. V. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104553 · Cited by 11 · see citing works
Polusani, S. R., Cortez, V. A., Esparza, J. M., Nguyen, H. N., Fan, H., Velagaleti, G. V. N., Butler, M. J., Kinney, M. C., Oyajobi, B. O., Habib, S. L., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33497 · Cited by 10 · see citing works
Urinary Metabolomic Profiling Analysis and Evaluation of the Effect of Ecklonia cava Extract Intake
Kim, J., Jung, Y., Lee, E., Jang, S. Y., Ryu, D. H., Kwon, O., & Hwang, G. (2020) · Nutrients · doi:10.3390/nu12051407 · Cited by 10 · see citing works
Zhang, X., Tang, Q., & Xu, L. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.39.909 · Cited by 10 · see citing works
Kim, M., Park, Y. G., Lee, H.-J., Lim, S. J., Ahn, H. R., Jung, S. H., & Nho, C. W. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.002 · Cited by 10 · see citing works
Grifoni, D., Bustaffa, E., Sabatino, L., Calastrini, F., Minichilli, F., Gaggini, M., Berti, S. L., & Vassalle, C. (2025) · Antioxidants · doi:10.3390/antiox14050572 · Cited by 9 · see citing works
Shah, R., Thomas, R., & Mehta, D. S. (2013) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2013.810772 · Cited by 7 · see citing works
Seong, M., Kim, Y. J., Park, S., Kim, H., & Kwon, O. (2020) · Nutrients · doi:10.3390/nu12113226 · Cited by 8 · see citing works
Muggeridge, D. J., Goszcz, K., Treweeke, A. T., Adamson, J., Hickson, K. A., Crabtree, D. R., & Megson, I. L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01293 · Cited by 7 · see citing works
Zhang, S., Hu, W., Li, Y., Yu, J., Sang, S., Alsalman, Z. M., & Xie, D.-Q. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i35.12909 · Cited by 6 · see citing works
Wu, Y., & Huang, H. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5099 · Cited by 6 · see citing works
Antonova, V. V., Evseev, A. K., Goroncharovskaya, I. V., Ryzhkov, A. Y., Grebenchikov, O. A., & Курбанович, Ш. А. (2023) · Annals of critical care · doi:10.21320/1818-474x-2023-4-185-196 · Cited by 5 · see citing works
Comparison of Mean Platelet Volume Values between Patients with Nasal Polyp and Healthy Individuals
Çevik, C., Yengil, E., Akbay, E., Arlı, C., Gülmez, M. İ., & Akoğlu, E. (2013) · Turkish Archives of Otorhinolaryngology · doi:10.5152/tao.2013.119 · Cited by 5 · see citing works
Connections between apolipoprotein E genotypes and the development of cardiovascular diseases
Végh, C., Langmár, Z., Szerző, M., Ágota, A., Marosi, K., Szabolcs, Z., & Nagy, Z. B. (2012) · Orvosi Hetilap · doi:10.1556/oh.2012.29508 · Cited by 5 · see citing works
Increased oxidative stress biomarkers in central serous chorioretinopathy
Akıdan, E. E., Yılmaz, E., Yılmaz, N., & Akıdan, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-71890-6 · Cited by 4 · see citing works
Yu, R., Song, J., Wu, J., Niu, D., Ma, L., Zong, C., Ju, H., & Wang, J. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0786 · Cited by 4 · see citing works
Antona, M. E., Ramos, C., Orzuza, R., Gonzalez, G. E., González, P. M., Cabrera, J., Monteiro, A. F., Zago, V., Friedman, S., Steimetz, T., et al. (2024) · Odontology · doi:10.1007/s10266-024-01042-9 · Cited by 3 · see citing works
Chen, J., Zhang, K., Yi, L., Jin, S., Xiaohong, G., Tao, R., & Chengwang, T. (2022) · PubMed Central · doi:10.19852/j.cnki.jtcm.2022.03.008 · Cited by 3 · see citing works
Role of biological markers in stem cell aging and its implications in therapeutic processes
Sittadjody, S., Ali, A., Thangasamy, T., Akila, M., Kumaran, R., & Opara, E. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00010-4 · Cited by 3 · see citing works
El‐Sayed, K. M. F., Mahlandt, E., Schlicht, K., Enthammer, K., Tölle, J., Wagner, J., Hartmann, K., Ebeling, P. R., Graetz, C., Laudes, M., et al. (2024) · Journal of Periodontal Research · doi:10.1111/jre.13319 · Cited by 2 · see citing works
Wu, H.-Y., Gao, T., Cao, Y., Diao, J., Chang, F.-J., Qi, J., & Wang, C. (2019) · AMB Express · doi:10.1186/s13568-019-0901-7 · Cited by 2 · see citing works
Efthymiou, A., Anastasiadou, P. A., Anagnostou, E., Koliakos, G., Kalfas, S., & Vouros, I. D. (2025) · Dentistry Journal · doi:10.3390/dj13070328 · Cited by 1 · see citing works
Tanweer, S., Mehmood, T., Zainab, S., Ahmad, Z., Khan, M. A., Shehzad, A., Khaliq, A., Chughtai, F., & Liaqat, A. (2021) · Nutrition & Food Science · doi:10.1108/nfs-02-2021-0069
Nogueira, M. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2020.tde-20122021-112905
Youssef, M. M., & Morsy, S. M. (2022) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2022.135483.2089
Miller, Y. I., & Tsimikas, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28786-9.00007-4
Kovalevych, R. R., Valivko, T. V., Крамар, С., Kulitska, M. I., & Yaremchuk, О. Z. (2026) · Reports of Morphology · doi:10.31393/morphology-journal-2026-32(2)-07
Ji, L., & Du, H. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1968314
Shrestha, D. (2014) · Scholar Commons (University of South Carolina)
- Authors
- Itabe, H.
- Affiliations
- SHOWA Medical University (JP)
- Corresponding author
- Itabe, Hiroyuki
- ORCID
- Itabe, Hiroyuki
- Venue
- Journal of Clinical Biochemistry and Nutrition
- Published
- 2012
- Volume
- 51
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0912-0009 (ISSN-L)
- 1880-5086
- PMC
- PMC3391857
- OpenAlex
- W2058659027
- Cited by
- 87
- References
- 63
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Biochemistry and Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Tokushima
- Japan Society for the Promotion of Science (24590094)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- oxidized LDL, oxidative stress, biomarkers, atherosclerosis, periodontitis, gingival crevicular fluid, oxidized phosphatidylcholine, monoclonal antibodies, acute myocardial infarction, cerebral infarction, chronic kidney disease, hemodialysis, ApoE-deficient mice, aortic atherosclerosis, disease prediction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review