Cited by 87Antioxidant Activity and Oxidative StressAtherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Oxidized low-density lipoprotein as a biomarker of in vivo oxidative stress: From atherosclerosis to periodontitis

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Itabe, Hiroyuki·2012·Journal of Clinical Biochemistry and Nutrition

Abstract

Oxidized low-density lipoprotein is known as an important factor in the development of atherosclerosis. The introduction of a sensitive procedure for the determination of oxidized low-density lipoprotein in human circulating plasma using a monoclonal antibody recognizing oxidized phosphatidylcholines has opened new fields of research based on in vivo oxidized low-density lipoprotein. The plasma oxidized low-density lipoprotein levels are significantly elevated in patients with acute myocardial infarction, cerebral infarction or chronic renal failure accompanied by hemodialysis. It was found that the plasma oxidized low-density lipoprotein level increased prior to aortic atherosclerotic lesion enlargement in apolipoprotein E-knockout mice. Recent studies have pointed out that oxidized low-density lipoprotein is transferrable between vessel wall tissue and the circulation, so it is a reasonable hypothesis that plasma oxidized low-density lipoprotein levels reflect the oxidative status at local sites of atherogenesis. Oxidized low-density lipoprotein measurement has been applied to human gingival crevicular fluids, which can be collected easily and safely, and relatively high levels of oxidized low-density lipoprotein were shown to be present. These findings, together with recent clinical follow-up studies, suggest that oxidized low-density lipoprotein is a predictive biomarker of a variety of diseases related to oxidative stress. This review summarizes the current understanding of in vivo oxidized low-density lipoprotein and its potential significance as a biomarker of disease.

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  • Increased oxidative stress promotes the conversion of low-density lipoprotein (LDL) cholesterol to the more atherogenic oxidized LDL form (oxLDL).

    “increased oxidative stress has been found to promote the conversion of harmful low-density lipoprotein (LDL) cholesterol to the more atherogenic oxidized LDL form (oxLDL) [148,149].”

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Authors
Itabe, H.
Affiliations
SHOWA Medical University (JP)
Corresponding author
Itabe, Hiroyuki
Venue
Journal of Clinical Biochemistry and Nutrition
Published
2012
Volume
51
Issue
1
Pages
1-8
ISSN
  • 0912-0009 (ISSN-L)
  • 1880-5086
OpenAlex
W2058659027
Cited by
87
References
63
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 1
FWCI
4.94
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Biochemistry and Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Tokushima
  • Japan Society for the Promotion of Science (24590094)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
oxidized LDL, oxidative stress, biomarkers, atherosclerosis, periodontitis, gingival crevicular fluid, oxidized phosphatidylcholine, monoclonal antibodies, acute myocardial infarction, cerebral infarction, chronic kidney disease, hemodialysis, ApoE-deficient mice, aortic atherosclerosis, disease prediction

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