Cited by 338Probiotics and Fermented FoodsSteroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

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Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol

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Lye, H.-S., Rusul, G., Liong, M.-T.·2010·Journal of Dairy Science

DOI 10.3168/jds.2009-2574

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Abstract

Fifteen strains of Lactobacillus and Bifidobacterium were screened based on their ability to adhere to hydrocarbons via the determination of cellular hydrophobicity. Lactobacillus acidophilus ATCC 314, L. acidophilus FTCC 0291, Lactobacillus bulgaricus FTCC 0411, L. bulgaricus FTDC 1311, and L. casei ATCC 393 showed greater hydrophobicity and, thus, were selected for examination of cholesterol-removal properties. All selected strains showed changes in cellular fatty acid compositions, especially total fatty acids and saturated and unsaturated fatty acids in the presence of cholesterol compared with those grown in the absence of cholesterol. In addition, we found that cells grown in media containing cholesterol were more resistant to sonication and enzymatic lysis compared with those grown without cholesterol. We further evaluated the location of the incorporated cholesterol via the insertion of fluorescence probes into the cellular membrane. In general, enrichment of cholesterol was found in the regions of the phospholipid tails, upper phospholipids, and polar heads of the cellular membrane phospholipid bilayer. Our results also showed that lactobacilli were able to reduce cholesterol via conversion of cholesterol to coprostanol, aided by the ability of strains to produce cholesterol reductase. Our results provided experimental evidence to strengthen the hypothesis that probiotics could remove cholesterol via the incorporation of cholesterol into the cellular membrane and conversion of cholesterol to coprostanol. The strains studied may be potential health adjunct cultures in fermented dairy products with possible in vivo hypocholesterolemic effects.

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Authors: Lye, H.-S., Rusul, G., & Liong, M.-T.
Affiliations: Universiti Sains Malaysia (MY)
Corresponding author: Liong, M.-T.
ORCID: Liong, M.-T.
Venue: Journal of Dairy Science
Publisher: American Dairy Science Association
Published: 2010-04
Volume: 93
Issue: 4
Pages: 1383-1392
ISSN: 0022-0302 (ISSN-L)
DOI: 10.3168/jds.2009-2574
OpenAlex: W2051235818
Cited by: 338
References: 28
Citations by year: 2026: 9 · 2025: 21 · 2024: 21 · 2023: 27 · 2022: 28 · 2021: 37 · 2020: 27 · 2019: 28 · 2018: 24 · 2017: 20 · 2016: 19 · 2015: 14 · 2014: 18 · 2013: 12 · 2012: 20
FWCI: 22.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3212 d)
Locations: Journal of Dairy Science (publishedVersion)
PubMed (publishedVersion)
Funders: eScienceFund
Malaysian Ministry of Science
Technology and Innovation
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: cholesterol removal, coprostanol, Lactobacillus, Bifidobacterium, probiotics, membrane phospholipids, fatty acid composition, cell membrane stability, cholesterol-lowering effect, fermented dairy products, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei
MeSH terms: Bifidobacterium, Cell Membrane, Cholesterol, Cholestanol, Fatty Acids, Humans, Hypercholesterolemia, Lactobacillus, Oxidoreductases, Sonication, Probiotics, Cultured Milk Products

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Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol

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