Cited by 338Probiotics and Fermented FoodsSteroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

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Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol

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Lye, H.-S., Rusul, G., Liong, M.-T.·2010·Journal of Dairy Science

DOI 10.3168/jds.2009-2574

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Abstract

Fifteen strains of Lactobacillus and Bifidobacterium were screened based on their ability to adhere to hydrocarbons via the determination of cellular hydrophobicity. Lactobacillus acidophilus ATCC 314, L. acidophilus FTCC 0291, Lactobacillus bulgaricus FTCC 0411, L. bulgaricus FTDC 1311, and L. casei ATCC 393 showed greater hydrophobicity and, thus, were selected for examination of cholesterol-removal properties. All selected strains showed changes in cellular fatty acid compositions, especially total fatty acids and saturated and unsaturated fatty acids in the presence of cholesterol compared with those grown in the absence of cholesterol. In addition, we found that cells grown in media containing cholesterol were more resistant to sonication and enzymatic lysis compared with those grown without cholesterol. We further evaluated the location of the incorporated cholesterol via the insertion of fluorescence probes into the cellular membrane. In general, enrichment of cholesterol was found in the regions of the phospholipid tails, upper phospholipids, and polar heads of the cellular membrane phospholipid bilayer. Our results also showed that lactobacilli were able to reduce cholesterol via conversion of cholesterol to coprostanol, aided by the ability of strains to produce cholesterol reductase. Our results provided experimental evidence to strengthen the hypothesis that probiotics could remove cholesterol via the incorporation of cholesterol into the cellular membrane and conversion of cholesterol to coprostanol. The strains studied may be potential health adjunct cultures in fermented dairy products with possible in vivo hypocholesterolemic effects.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Lactic acid starter and probiotic bacteria: a comparative “in vitro” study of probiotic characteristics and biological barrier resistance
Vinderola, C. G., & Reinheimer, J. A. (2003) · Food Research International · doi:10.1016/s0963-9969(03)00098-x · Cited by 570
Acid and Bile Tolerance and Cholesterol Removal Ability of Lactobacilli Strains
Liong, M., & Shah, N. P. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)72662-x · Cited by 538
Market potential for probiotics
Stanton, C., Gardiner, G. E., Meehan, H., Collins, K. J., Fitzgerald, G. F., Lynch, P. B., & Ross, R. P. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.476s · Cited by 416
Degradation of steroids in the human gut
MacDonald, I. A., Bokkenheuser, V. D., Winter, J., Cerone-McLernon, A. M., & Mosbach, E. H. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37944-x · Cited by 332
Surface Properties of Bifidobacterial Strains of Human Origin
Pérez, P. F., Minnaard, Y., Disalvo, E. A., & Antoni, G. L. D. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.1.21-26.1998 · Cited by 268
Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol
Kiessling, G., Schneider, J., & Jahreis, G. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601399 · Cited by 256
The Improvement of Hypertension by Probiotics: Effects on Cholesterol, Diabetes, Renin, and Phytoestrogens
Lye, H., Kuan, C.-Y., Ewe, J., Fung, W.-Y., & Liong, M. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10093755 · Cited by 245
An In Vitro Study of the Probiotic Potential of a Bile-Salt-Hydrolyzing Lactobacillus fermentum Strain, and Determination of Its Cholesterol-Lowering Properties
Pereira, D. I. A., McCartney, A. L., & Gibson, G. R. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.8.4743-4752.2003 · Cited by 215
Life, death and membrane bilayers
Hulbert, A. J. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00399 · Cited by 201

Show all 28 references

Research works printed but not linked: 1

Khedkar, 1993, Effect of feeding acidophilus milk on serum cholesterol in human volunteers, J. Dairy Foods Home Sci., 12, 33

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Kim, G., Yoon, Y., Park, J., Park, J. W., Noh, M., Kim, H., Park, C.-H., Kwon, H., Park, J. H., Kim, Y., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01374-0 · Cited by 69
RETRACTED ARTICLE: Effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial
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Hypocholesterolaemic effect and anti-hypertensive properties of probiotics and prebiotics: A review
Miremadi, F., Sherkat, F., & Stojanovska, L. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.016 · Cited by 60
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Moura, C. S., Lollo, P. C. B., Morato, P. N., Esmerino, E. A., Margalho, L. P., Santos-Junior, V. A., Coimbra, P. T., Cappato, L. P., Silva, M. C. R., Garcia-Gomes, A. D. S., et al. (2016) · Food Research International · doi:10.1016/j.foodres.2016.10.042 · Cited by 57
Effect of cooling rate, freeze-drying, and storage on survival of free and immobilized Lactobacillus casei ATCC 393
Dimitrellou, D., Kandylis, P., & Kourkoutas, Y. (2016) · LWT · doi:10.1016/j.lwt.2016.01.063 · Cited by 57
Obtaining paraprobiotics from Lactobacilus acidophilus, Lacticaseibacillus casei and Bifidobacterium animalis using six inactivation methods: Impacts on the cultivability, integrity, physiology, and morphology
de Almada, C. N., Almada-Érix, C. N., Bonatto, M. S., Pradella, F. M., dos Santos, P., Abud, Y., Farias, A. S., Martínez, J., Filho, C. B. S., Lollo, P. C. B., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104826 · Cited by 56
Research advances with regards to clinical outcome and potential mechanisms of the cholesterol-lowering effects of probiotics
Zhuang, G., Liu, X., Zhang, Q., Tian, F., Zhang, H., Zhang, H.-P., & Chen, W. (2012) · Clinical Lipidology · doi:10.2217/clp.12.40 · Cited by 55
Potential of three probiotic lactobacilli in transforming star fruit juice into functional beverages
Lu, Y., Tan, C., Chen, D., & Liu, S. (2018) · Food Science & Nutrition · doi:10.1002/fsn3.775 · Cited by 55
Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels
Nath, A., Molnár, M. A., Csighy, A., Kőszegi, K., Galambos, I., Pásztor‐Huszár, K., Koris, A. K., & Vatai, G. N. (2018) · Medicina · doi:10.3390/medicina54060098 · Cited by 56
Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials
Mo, R., Zhang, X., & Yang, Y. (2019) · Medicina Clínica · doi:10.1016/j.medcli.2018.09.007 · Cited by 52
Components of a Neanderthal gut microbiome recovered from fecal sediments from El Salt
Rampelli, S., Turroni, S., Mallol, C., Gómez, C. M. H., Galván, B., Sistiaga, A., Biagi, E., Astolfi, A., Brigidi, P., Benazzi, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01689-y · Cited by 52
Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
Chaiyasut, C., Sivamaruthi, B. S., Kesika, P., Khongtan, S., Khampithum, N., Thangaleela, S., Peerajan, S., Bumrungpert, A., Chaiyasut, K., Sirilun, S., et al. (2021) · Foods · doi:10.3390/foods10071580 · Cited by 50
Influence of daily consumption of synbiotic soy-based product supplemented with okara soybean by-product on risk factors for cardiovascular diseases
Bedani, R., Rossi, E. A., Cavallini, D., Pinto, R. A., Vendramini, R. C., Augusto, E. M., Abdalla, D. S. P., & Saad, S. M. I. (2014) · Food Research International · doi:10.1016/j.foodres.2014.11.006 · Cited by 49
Rhizospheric Lactobacillus plantarum (Lactiplantibacillus plantarum) strains exhibit bile salt hydrolysis, hypocholestrolemic and probiotic capabilities in vitro
Singhal, N., Singh, N. S., Mohanty, S., Kumar, M., & Virdi, J. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-94776-3 · Cited by 48
Evaluation of Lactobacillus casei ATCC 393 protective effect against spoilage of probiotic dry-fermented sausages
Sidira, M., Galanis, Α., Nikolaou, A., Kanellaki, M., & Kourkoutas, Y. (2014) · Food Control · doi:10.1016/j.foodcont.2014.02.024 · Cited by 48
Probiotic kefir consumption improves serum apolipoprotein A1 levels in metabolic syndrome patients: a randomized controlled clinical trial
Koyu, E. B., Sarer-Yurekli, B. P., Karagözlü, C., Köse, F. A., Özgen, G., & Büyüktuncer, Z. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.02.006 · Cited by 51
Antibiotic-induced gut microbiota depletion exacerbates host hypercholesterolemia
Kappel, B. A., Angelis, L. D., Puetz, A., Ballanti, M., Menghini, R., Marx, N., & Federici, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106570 · Cited by 49
Bile acid metabolism in health and ageing-related diseases
Li, X., Fang, C., Zhao, R., Zou, L., Miao, H., & Zhao, Y. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116313 · Cited by 50
In Vitro Characterization of Lactic Acid Bacteria from Indonesian Kefir Grains as Probiotics with Cholesterol-Lowering Effect
Yusuf, D., Nuraida, L., Hariyadi, R. D., & Hunaefi, D. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1910.10028 · Cited by 47
Screening for cholesterol-lowering probiotic based on deoxycholic acid removal pathway and studying its functional mechanisms in vitro
Guo, C., Zhang, L., Han, X., Yi, H., Li, J., Tuo, Y., Zhang, Y., Du, M., Shan, Y., & Yang, L. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.08.003 · Cited by 46
Production of a novel probiotic yogurt by incorporation of L. casei enriched fresh apple pieces, dried raisins and wheat grains
Bosnea, L. A., Kopsahelis, N., Kokkali, V., Τέρπου, Α., & Kanellaki, M. (2016) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2016.11.010 · Cited by 47
Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase.
Lew, L.-C., Choi, S. B., Khoo, B. Y., Sreenivasan, S., Ong, K.-L., & Liong, M. (2018) · Europe PMC (PubMed Central) · doi:10.5851/kosfa.2018.38.2.350 · Cited by 46
Fenugreek Counters the Effects of High Fat Diet on Gut Microbiota in Mice: Links to Metabolic Benefit
Bruce‐Keller, A. J., Richard, A. J., Fernandez-Kim, S.-O., Ribnicky, D., Salbaum, J. M., Newman, S. S., Carmouche, R. P., & Stephens, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-58005-7 · Cited by 47
Effect of Ultrasound on the Growth of Probiotics and Bioconversion of Isoflavones in Prebiotic-Supplemented Soymilk
Yeo, S. K., & Liong, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103974d · Cited by 46
Functional foods as a formulation ingredients in beverages: technological advancements and constraints
Sharma, S., Singh, A., Sharma, S., Kant, A., Sevda, S., Taherzadeh, M. J., & Garlapati, V. K. (2021) · Bioengineered · doi:10.1080/21655979.2021.2005992 · Cited by 51
Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
Kriaa, A., Bourgin, M., Mkaouar, H., Jablaoui, A., Akermi, N., Soussou, S., Maguin, E., & Rhimi, M. (2019) · Catalysts · doi:10.3390/catal9020167 · Cited by 50
A Brief Overview on Probiotics: The Health Friendly Microbes
Mishra, S., & Acharya, S. (2021) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2285 · Cited by 48

Authors: Lye, H.-S., Rusul, G., & Liong, M.-T.
Affiliations: Universiti Sains Malaysia (MY)
Corresponding author: Liong, M.-T.
ORCID: Liong, M.-T.
Venue: Journal of Dairy Science
Publisher: American Dairy Science Association
Published: 2010-04
Volume: 93
Issue: 4
Pages: 1383-1392
ISSN: 0022-0302 (ISSN-L)
DOI: 10.3168/jds.2009-2574
OpenAlex: W2051235818
Cited by: 338
References: 28
Citations by year: 2026: 9 · 2025: 21 · 2024: 21 · 2023: 27 · 2022: 28 · 2021: 37 · 2020: 27 · 2019: 28 · 2018: 24 · 2017: 20 · 2016: 19 · 2015: 14 · 2014: 18 · 2013: 12 · 2012: 20
FWCI: 22.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3212 d)
Locations: Journal of Dairy Science (publishedVersion)
PubMed (publishedVersion)
Funders: eScienceFund
Malaysian Ministry of Science
Technology and Innovation
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: cholesterol removal, coprostanol, Lactobacillus, Bifidobacterium, probiotics, membrane phospholipids, fatty acid composition, cell membrane stability, cholesterol-lowering effect, fermented dairy products, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei
MeSH terms: Bifidobacterium, Cell Membrane, Cholesterol, Cholestanol, Fatty Acids, Humans, Hypercholesterolemia, Lactobacillus, Oxidoreductases, Sonication, Probiotics, Cultured Milk Products

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Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol

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