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Lactobacillus crispatus and its Nonaggregating Mutant in Human Colonization Trials
Open accessAbstract
A wild-type Lactobacillus crispatus, showing a cell aggregation phenotype and its spontaneous nonaggregating mutant were compared for their in vitro adhesion properties to human ileal mucus and to a cultured human colonic cell line (Caco2) and for their in vivo colonization and adhesion potential with colonoscopy patients as volunteers in feeding trials. The wild-type strain adhered better to mucus or to Caco2 cells than did the mutant. Altogether, three human trials with the wild type and two with the mutant strain were performed. In two of the trials, the wild type could be recovered from either fecal samples or biopsies taken from the colon, while the mutant strain could not be demonstrated in either of the trials where it was used. The L. crispatus colonies recovered from the trials were often mixed, and several enterococci and lactobacillus strains coaggregating with L. crispatus wild type could be isolated. The results indicate that the surface-mediated properties, such as aggregation, of lactobacilli can have a role in adhesion and colonization.
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“Auto-aggregation ability correlates positively with adherence to human epithelial cell lines and the ability to co-aggregate with Listeria monocytogenes, Staphylococcus aureus and pathogenic Escherichia coli [8, 12–16].”
From Bistable auto-aggregation phenotype in Lactiplantibacillus plantarum emerges after cultivation in in vitro colonic microbiota (2021) · cites this paper as [8]
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Metadata
- Authors
- Cesena, C., Morelli, L., Alander, M., Siljander, T., Tuomola, E., Salminen, S., Mattila-Sandholm, T., Vilpponen-Salmela, T., & von Wright, A.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- VTT Technical Research Centre of Finland (FI)
- Corresponding author
- Morelli, L.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2001-05
- Volume
- 84
- Issue
- 5
- Pages
- 1001-1010
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W1974465194
- Cited by
- 123
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus crispatus, cell aggregation, bacterial adhesion, Caco-2 cells, probiotics, co-aggregation, Enterococcus, fecal recovery
- MeSH terms
- Bacterial Adhesion, Biopsy, Cells, Cultured, Colon, Feces, Humans, Intestinal Mucosa, Lactobacillus, Mutation, Phenotype, Caco-2 Cells, Probiotics
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