Cited by 129Seaweed-derived Bioactive CompoundsImmunotoxicology and immune responsesAquaculture disease management and microbiota

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Enhancement of antibody production in mice by dietary Spirulina platensis

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HAYASHI, Osamu, KATOH, Toshimitsu, OKUWAKI, Yoshiyuki·1994·Journal of Nutritional Science and Vitaminology

DOI 10.3177/jnsv.40.431

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Abstract

Mice fed a Spirulina platensis diet showed increased numbers of splenic antibody-producing cells in the primary immune response to sheep red blood cells (SRBC). However, immunoglobulin G (IgG)-antibody production in the secondary immune response was hardly affected. The percentage of phagocytic cells in peritoneal macrophages from the mice fed S. platensis diet, as well as the proliferation of spleen cells by either concanavalin A (Con A) or phytohemagglutinin (PHA) was significantly increased. Addition of a hot-water extract of S. platensis (SHW) to an in vitro culture of spleen cells markedly increased proliferation of these cells, whereas culture of thymus cells was scarcely affected. The Spirulina extract also significantly enhanced interleukin-1 (IL-1) production from peritoneal macrophages. Addition to the in vitro spleen cell culture of SHW as well as the supernatant of macrophages stimulated with SHW resulted in enhancement of antibody production, that is, an increase of the number of PFC. These results suggest that Spirulina enhances the immune response, particularly the primary response, by stimulating macrophage functions, phagocytosis, and IL-1 production.

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Further improvements in the plaque technique for detecting single antibody-forming cells.
Cunningham, A. J., & Szenberg, A. (1968) · PubMed · Cited by 2,153
Spirulina, the edible microorganism.
Ciferri, O. (1983) · Microbiological Reviews · doi:10.1128/mmbr.47.4.551-578.1983 · Cited by 745
Cytokines as communication signals between leukocytes and endothelial cells
Mantovani, A., & Dejana, E. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90270-3 · Cited by 517
Microalgae as food and supplement
Kay, R. A., & Barton, L. L. (1991) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399109527556 · Cited by 408
A Localized Haemolysis in Gel Method for the Detection of Cells Producing 7S Antibody: Detection of Cells producing 7S Antibodies by the Plaque Technique
Šterzl, J., & Říha, I. (1965) · Nature · doi:10.1038/208858a0 · Cited by 220
Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae
Schwartz, J., Shklar, G., Reid, S., & Trickier, D. (1988) · Nutrition and Cancer · doi:10.1080/01635588809513979 · Cited by 136
Studies on the growth of Spirulina platensis. on the pure culture of Spirulina platensis
Ogawa, T., & Terui, G. (1970) · 醗酵工學雑誌 · Cited by 127
Cholesterol lowering effect of spirulina.
Nakaya, N., Homma, Y., & Goto, Y. (1988) · Nutrition reports international · Cited by 108
Interleukin 1 activity in normal human urine.
Kimball, E. S., Pickeral, S., Oppenheim, J. J., & Rossio, J. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.256 · Cited by 90

Show all 16 references

Research works printed but not linked: 1

Inaba, K. (1990): Laboratory Methods in Lymphocyte Studies, ed. by Yata, J., and Fujiwara, M., Chugai Igaku Co., Tokyo, pp. 370-396.

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Production of safe cyanobacterial biomass for animal feed using wastewater and drinking water treatment residuals
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Antioxidative and Hepatoprotective Effects of Spirulina
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Retracted : Effect of concentration of the microalga Dunaliella tertiolecta on survival and growth of fairy shrimp, Phallocryptus spinosa Milne Edwards, 1840 (Crustacea: Anostraca)
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Retracted
Antibacterial activities of the extracts of cyanobacteria and green algae isolated from desert soil in Riyadh, Kingdom of Saudi Arabia
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Self-citation
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Development of antihypertensive natural seasoning using beef hydrolyzate
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Spirulina and Immunity
Keen, C. L., Belay, A., Gershwin, M. E., & Borchers, A. T. (2007) · CRC Press eBooks · doi:10.1201/9781420052572.ch8 · Cited by 3

Authors: HAYASHI, O., KATOH, T., & OKUWAKI, Y.
Affiliations: Japan Nutrition University (JP)
Venue: Journal of Nutritional Science and Vitaminology
Publisher: Center for Academic Publications Japan
Published: 1994
Volume: 40
Issue: 5
Pages: 431-441
ISSN: 0301-4800 (ISSN-L)
1881-7742
DOI: 10.3177/jnsv.40.431
OpenAlex: W2089254287
Cited by: 129
References: 16
Citations by year: 2026: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 12 · 2012: 10
FWCI: 2.39
Type: journal article
Language: en
Open access: diamond
doi.org
Locations: Journal of Nutritional Science and Vitaminology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Keywords: Spirulina platensis, dietary supplementation, antibody production, primary immune response, secondary immune response, peritoneal macrophages, phagocytosis, interleukin-1, spleen cell proliferation, concanavalin A, phytohemagglutinin, thymus cells, sheep red blood cells, immunomodulation
MeSH terms: Cyanobacteria, Animals, Antibody Formation, Cell Division, Concanavalin A, Diet, Erythrocytes, Immunoglobulin G, Interleukin-1, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Phagocytes, Phytohemagglutinins, Sheep, Spleen, Macrophages, Peritoneal, Mice

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Enhancement of antibody production in mice by dietary Spirulina platensis

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