Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin
Open accessAbstract
We performed a double-blind, placebo-controlled trial to clinically evaluate the protective and ameliorative effects of ellagic acid-rich pomegranate extract on pigmentation in the skin after ultraviolet ray (UV) irradiation, using female subjects in their 20s to 40s. Thirteen healthy volunteers per group were randomly assigned to three groups; namely, high dose (200 mg/d ellagic acid), low dose (100 mg/d ellagic acid) and control (0 mg/d ellagic acid: placebo). Each group received the respective test foods for 4 wk. Each subject received a 1.5 MED (minimum erythema dose) of UV irradiation on an inside region of the right upper arm, based on the MED value measured on the previous day. Luminance (L), melanin and erythema values were measured before the start of the test food intake, and after 1, 2, 3 and 4 wk following the start of the test food intake. Further, questionnaires were conducted regarding the condition of the skin before the start of the test food intake and at the termination of the test food intake. As a result, decreasing rates of L values from the baseline in the low- and high-dose groups were inhibited by 1.35% and 1.73% respectively, as compared to the control group. Further, a stratified analysis using subjects with a slight sunburn revealed an inhibited decrease of L values compared with the control group at 1, 2 (p<0.01, respectively) and 4 wk (p<0.05) after the start of the test food intake in the low-dose group, and at 2 and 3 wk (p<0.05) in the high-dose group. Furthermore, the results of questionnaires showed ameliorating tendencies due to the test food, in some items such as "brightness of the face" and "stains and freckles." Based on the above-mentioned results, it is suggested that ellagic acid-rich pomegranate extract, ingested orally, has an inhibitory effect on a slight pigmentation in the human skin caused by UV irradiation.
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Pomegranate extract has photochemoprotective, antioxidant, anti-inflammatory and antiproliferative properties.
“Research has confirmed the photochemoprotective, antioxidant, anti-inflammatory and antiproliferative properties of pomegranate extract.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [210]
Pomegranate fruit extract improves the color of the skin and restores the glow of skin exposed to UV radiation.
“and also to improve the color of the skin and restore the glow of skin exposed to UV radiation [210].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [210]
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A Review of Acne Etiology and Treatment in Iranian Traditional Medicine
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Natural Product-based Skin Whitening Agents: A Comprehensive Review
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Ellagic acid can improve stroke by regulating gut microbiota
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- Authors
- KASAI, K., YOSHIMURA, M., KOGA, T., ARII, M., & KAWASAKI, S.
- Affiliations
- Kikkoman (Japan) (JP)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2006
- Volume
- 52
- Issue
- 5
- Pages
- 383-388
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W1969880493
- Cited by
- 105
- References
- 14
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 3 · 2018: 10 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- ellagic acid, pomegranate extract, melanin, sunburn, dietary supplementation, photoprotection, skin lightening
- MeSH terms
- Administration, Oral, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Ellagic Acid, Erythema, Female, Humans, Plant Extracts, Surveys and Questionnaires, Reference Values, Skin Pigmentation, Time Factors, Ultraviolet Rays, Lythraceae
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