Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

Davinelli, Sergio; Bertoglio, Juan Carlos; Polimeni, Ascanio; Scapagnini, Giovanni

doi:10.2174/1381612823666171109102426

Cited by 57Skin Protection and AgingPhytochemicals and Antioxidant Activitiesmelanin and skin pigmentation

Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

Davinelli, Sergio, Bertoglio, Juan Carlos, Polimeni, Ascanio, Scapagnini, Giovanni·2018·Current Pharmaceutical Design

DOI 10.2174/1381612823666171109102426

Open this paper in CoChat — free account

Abstract

Background: Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin structure, function and appearance. Polyphenols, which are secondary plant metabolites, represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. The main objective is to provide an overview of the existing literature linking skin aging and the ability of polyphenols as regulatory elements able to maintain skin homeostasis. Methods: In this review, we discuss recent progress in understanding the molecular bases of skin aging, with specific emphasis on some well known and extensively studied polyphenols which have significant anti-aging influences and photoprotective effects. Results: Although no relevant clinical data exist and standard delivery systems have not been established, promising results have been obtained in many in vitro and animal models. A wide variety of polyphenols may minimize mechanisms underlying the functional manifestations of photoaging and chronological skin aging. Conclusion: Polyphenols exert their influence mostly through their antioxidant and anti-inflammatory effects, thereby abrogating collagen degradation and/or increasing procollagen synthesis.

Integrity signals

Registry

Crossref · 10.2174/1381612823666171109102426

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Resveratrol has very low solubility and high sensitivity to oxidation, making it unstable.
“However, one should keep in mind that resveratrol has very low solubility and high sensitivity to oxidation, thus making this molecule very unstable ([94] and references therein).”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [94]
Interaction of resveratrol with its specific binding partner blocks apoptotic events and mitochondrial dysfunctions in keratinocytes, delaying skin aging.
“As recently reviewed by Davinelli and colleagues [94], the interaction of resveratrol with the specific binding partner is able to block apoptotic events and mitochondrial dysfunctions in keratinocytes, delaying skin aging.”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [94]
Polyphenols reduce oxidative damage and inflammation in the skin through antioxidant and anti-inflammatory effects, mainly by inhibiting collagen degradation, increasing collagen synthesis, and inhibiting inflammation, involving regulation of matrix metalloproteinases, cytokines, and signaling pathways such as Nrf2, NF-κB, and MAPK.
“Polyphenols reduce oxidative damage and inflammation in the skin through their antioxidant and anti-inflammatory effects, mainly by inhibiting collagen degradation, increased collagen synthesis, and inhibiting inflammation, which involves the regulation of matrix metalloproteinases, cytokines, and signaling pathways (e.g., Nrf2, NF-κB, MAPK, etc.) [111,112].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [111]

1 retracted

RETRACTED: Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin
Vayalil, P. K., Elmets, C. A., & Katiyar, S. K. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg025 · Cited by 212 · see citing works
Retracted
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175 · see citing works
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works
Chemistry and biochemistry of dietary polyphenols
Tsao, R. (2010) · Nutrients · doi:10.3390/nu2121231 · Cited by 2,415 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Why do we age?
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works
Synergy research: approaching a new generation of phytopharmaceuticals.
Wagner, H., & Ulrich-Merzenich, G. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.12.018 · Cited by 1,296 · see citing works
Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms
Nichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103 · see citing works
UV-light-induced signal cascades and skin aging
Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 987 · see citing works
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980 · see citing works
Role of antioxidants in the skin: Anti-aging effects
Masaki, H. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.03.003 · Cited by 788 · see citing works
Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – a review
Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706 · see citing works
Molecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567 · see citing works
Characteristics of the Aging Skin
Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2013) · Advances in Wound Care · doi:10.1089/wound.2011.0356 · Cited by 535 · see citing works
The complexity of the Nrf2 pathway: beyond the antioxidant response
Huang, Y. S., Li, W., Su, Z., & Kong, A. T. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.001 · Cited by 449 · see citing works
Matrix metalloproteinase inhibition by green tea catechins
Demeule, M., Brossard, M., Pagé, M., Gingras, D., & Béliveau, R. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00009-1 · Cited by 429 · see citing works
Protective effects of silymarin against photocarcinogenesis in a mouse skin model
Katiyar, S. K., Korman, N. J., Mukhtar, H., & Agarwal, R. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.8.556 · Cited by 355 · see citing works
Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works
Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds
Cerdá, B., Periago, P., Espín, J. C., & Tomás-Barberán, F. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050384i · Cited by 301 · see citing works
Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets
Cho, J.-W., Lee, K.-S., & Kim, C.-W. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.3.469 · Cited by 282 · see citing works
Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes
Hseu, Y.-C., Chou, C.-W., Senthil Kumar, K. J., Fu, K.-T., Wang, H.-M., Hsu, L.-S., Kuo, Y.-H., Wu, C.-R., Chen, S.-C., & Yang, H.-L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.020 · Cited by 239 · see citing works
Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate
Afaq, F., Adhami, V. M., Ahmad, N., & Mukhtar, H. (2003) · Oncogene · doi:10.1038/sj.onc.1206206 · Cited by 236 · see citing works
Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals
Anunciato, T. P., & da Rocha Filho, P. A. (2012) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00600.x · Cited by 219 · see citing works
Equol: Pharmacokinetics and Biological Actions ,
Setchell, K. D. R., & Clerici, C. (2010) · Journal of Nutrition · doi:10.3945/jn.109.119784 · Cited by 212 · see citing works
NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
González‐Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Dolara, P., & Espı́n, J. C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000826 · Cited by 207 · see citing works
Green Tea and Skin
Katiyar, S. K., Ahmad, N., & Mukhtar, H. (2000) · Archives of Dermatology · doi:10.1001/archderm.136.8.989 · Cited by 204 · see citing works
Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes
Mantena, S. K., & Katiyar, S. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.032 · Cited by 203 · see citing works
Chemoprevention of photocarcinogenesis by selected dietary botanicals
Baliga, M. S., & Katiyar, S. K. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b505311k · Cited by 202 · see citing works
Protective effect of pomegranate‐derived products on UVB‐mediated damage in human reconstituted skin
Afaq, F., Zaid, M. I. A., Khan, N., Dreher, M. L., & Mukhtar, H. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00829.x · Cited by 201 · see citing works
Nrf2-A regulator of keratinocyte redox signaling
Schäfer, M., & Werner, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.018 · Cited by 192 · see citing works
Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV‐B irradiation
Bae, J., Choi, J., Kang, S., Lee, Y., Park, J., & Kang, Y. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01044.x · Cited by 186 · see citing works
Decreased Extracellular-Signal-Regulated Kinase and Increased Stress-Activated MAP Kinase Activities in Aged Human Skin In Vivo
Chung, J. H., Kang, S., Varani, J., Lin, J., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00009.x · Cited by 181 · see citing works
Understanding Premature Skin Aging
Uitto, J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372011 · Cited by 178 · see citing works
Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis
Kundu, J. K., & Surh, Y. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0096-8 · Cited by 173 · see citing works
Pomegranate Fruit Extract Modulates UV-B–mediated Phosphorylation of Mitogen-activated Protein Kinases and Activation of Nuclear Factor Kappa B in Normal Human Epidermal Keratinocytes¶
Afaq, F., Malik, A., Syed, D. N., Maes, D. H., Matsui, M. S., & Mukhtar, H. (2005) · Photochemistry and Photobiology · doi:10.1562/2004-08-06-ra-264.1 · Cited by 165 · see citing works
(−)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: Involvement of mitogen-activated protein kinase
Bae, J., Choi, J.-S., Choi, Y. J., Shin, S.-Y., Kang, S., Han, S. J., & Kang, Y. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.112 · Cited by 163 · see citing works
The influence of hormone replacement therapy on skin ageing
Sator, P. G., Schmidt, J. B., Sator, M. O., Huber, J., & Hönigsmann, H. (2001) · Maturitas · doi:10.1016/s0378-5122(00)00225-5 · Cited by 162 · see citing works
Orally Administered Green Tea Polyphenols Prevent Ultraviolet Radiation-Induced Skin Cancer in Mice through Activation of Cytotoxic T Cells and Inhibition of Angiogenesis in Tumors
Mantena, S. K., Meeran, S. M., Elmets, C. A., & Katiyar, S. K. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2871 · Cited by 150 · see citing works
Psychosocial Aspects Of Aging Skin
Gupta, M. A., & Gilchrest, B. A. (2005) · Dermatologic Clinics · doi:10.1016/j.det.2005.05.012 · Cited by 149 · see citing works
Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, Mitogen-Activated Protein Kinases, and Akt Signaling
Gu, M., Dhanalakshmi, S., Singh, R. P., Agarwal, C., & Agarwal, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1632 · Cited by 149 · see citing works
Skin regenerative potentials of curcumin
Thangapazham, R. L., Sharad, S., & Maheshwari, R. K. (2013) · BioFactors · doi:10.1002/biof.1078 · Cited by 143 · see citing works
Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women
Heinrich, U., Moore, C. E., De Spirt, S., Tronnier, H., & Stahl, W. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.136465 · Cited by 142 · see citing works
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor
Yang, S., Irani, K., Heffron, S. E., JURNAK, F. A., & Meyskens, F. L. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0229 · Cited by 141 · see citing works
A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin–Maqui Berry Extract (Delphinol®) on Oxidative Stress Biomarkers
Davinelli, S., Bertoglio, J. C., Zarrelli, A., Pina, R., & Scapagnini, G. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1080108 · Cited by 140 · see citing works
Self-citation
Protective Effects of Standardized Pomegranate (Punica granatum L.) Polyphenolic Extract in Ultraviolet-Irradiated Human Skin Fibroblasts
Pacheco-Palencia, L. A., Noratto, G. D., Hingorani, L., Talcott, S. T., & Mertens‐Talcott, S. U. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8005307 · Cited by 139 · see citing works
Curcumin induces heme oxygenase‐1 in normal human skin fibroblasts through redox signaling: Relevance for anti‐aging intervention
Lima, C. F., Pereira‐Wilson, C., & Rattan, S. I. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000221 · Cited by 136 · see citing works
Cell Autonomous and non-autonomous effects of senescent cells in the skin
Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.108 · Cited by 127 · see citing works
Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study
Davinelli, S., Scapagnini, G., Marzatico, F., Nobile, V., Ferrara, N., & Corbi, G. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.11.016 · Cited by 124 · see citing works
Self-citation
Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR–ERK pathway
Potapovich, A. I., Lulli, D., Fidanza, P., Kostyuk, V. A., Luca, C. D., Pastore, S., & Korkina, L. G. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.06.007 · Cited by 122 · see citing works
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122 · see citing works
Self-citation
Delivery of Resveratrol, a Red Wine Polyphenol, from Solutions and Hydrogels via the Skin
Hung, C., Lin, Y., Huang, Z.-R., & Fang, J. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.955 · Cited by 115 · see citing works
Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
Kluth�, D., Banning, A., Paur, I., Blomhoff, R., & Brigelius‐Flohé, R. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.028 · Cited by 114 · see citing works
The Role of Phytonutrients in Skin Health
Evans, J. A., & Johnson, E. J. (2010) · Nutrients · doi:10.3390/nu2080903 · Cited by 107 · see citing works
Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin
KASAI, K., YOSHIMURA, M., KOGA, T., ARII, M., & KAWASAKI, S. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.383 · Cited by 105 · see citing works
Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro
Demirovic, D., & Rattan, S. I. S. (2011) · Biogerontology · doi:10.1007/s10522-011-9326-7 · Cited by 99 · see citing works
Polydatin, A Natural Precursor of Resveratrol, Induces β-Defensin Production and Reduces Inflammatory Response
Ravagnan, G., Filippis, A. D., Cartenı̀, M., et al. (2012) · Inflammation · doi:10.1007/s10753-012-9516-8 · Cited by 99 · see citing works
Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn.) (Review)
Katiyar (2010) · International Journal of Oncology · doi:10.3892/ijo_00000586 · Cited by 88 · see citing works
Untitled work
(2007) · PubMed · Cited by 79 · see citing works
Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice
Sumiyoshi, M., & Kimura, Y. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.06.003 · Cited by 79 · see citing works
Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin.
Farris, P. K., Yatskayer, M., Chen, N., Krol, Y., & Oresajo, C. O. (2014) · PubMed · Cited by 79 · see citing works
Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells
Davinelli, S., Sapere, N., Visentin, M., Zella, D., & Scapagnini, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-28 · Cited by 76 · see citing works
Self-citation
The Modulatory Effect of Ellagic Acid and Rosmarinic Acid on Ultraviolet-B-Induced Cytokine/Chemokine Gene Expression in Skin Keratinocyte (HaCaT) Cells
Lembo, S., Balato, A., Caprio, R. D., Cirillo, T., Giannini, V., Gasparri, F., & Monfrecola, G. (2014) · BioMed Research International · doi:10.1155/2014/346793 · Cited by 75 · see citing works
Influence of Polyphenols on the Physiological Processes in the Skin
Ratz‐Łyko, A., Arct, J., Majewski, S. T., & Pytkowska, K. (2015) · Phytotherapy Research · doi:10.1002/ptr.5289 · Cited by 72 · see citing works
In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake
Chiu, T., Huang, C., Lin, T.-J., Fang, J., Wu, N., & Hung, C. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.07.039 · Cited by 72 · see citing works
Targeting senescent cells: possible implications for delaying skin aging: a mini-review
Velarde, M. C., & Demaria, M. (2016) · Gerontology · doi:10.1159/000444877 · Cited by 69 · see citing works
Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites
Bastianetto, S., Dumont, Y., Duranton, A., Vercauteren, F., Breton, L., & Quirion, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012935 · Cited by 66 · see citing works
A Two-Year, Double-Blind, Randomized Placebo-Controlled Trial of Oral Green Tea Polyphenols on the Long-Term Clinical and Histologic Appearance of Photoaging Skin
JANJUA, R., MUNOZ, C., Gorell, E. S., Rehmus, W., Egbert, B. M., Kern, D. G., & Chang, A. L. S. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01183.x · Cited by 65 · see citing works
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin
Gu, M., Dhanalakshmi, S., Mohan, S., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi096 · Cited by 62 · see citing works
Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB
Haustead, D. J., Stevenson, A. W., Saxena, V., Marriage, F., Firth, M. J., Silla, R. C., Martin, L., Adcroft, K. F., Rea, S. M., Day, P. J., et al. (2016) · Scientific Reports · doi:10.1038/srep26846 · Cited by 59 · see citing works
Polyphenols: a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension
Davinelli, S., & Scapagnini, G. (2016) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-016-0149-0 · Cited by 55 · see citing works
Self-citation
Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System
Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works
Plant polyphenols and human skin: Friends or foes
Korkina, L., De Luca, C., & Pastore, S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06510.x · Cited by 47 · see citing works
The Role of Functional Foods in Cutaneous Anti-aging
Cho, S. (2014) · Journal of Lifestyle Medicine · doi:10.15280/jlm.2014.4.1.8 · Cited by 41 · see citing works
Ageing effects on the expression of cell defence genes after UVA irradiation in human male cutaneous fibroblasts using cDNA arrays
Hazane‐Puch, F., Valenti, K., Sauvaigo, S., Peinnequin, A., Mouret, C., Favier, A. E., & Béani, J. (2005) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2005.02.001 · Cited by 34 · see citing works
Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke
Sticozzi, C., Belmonte, G., Cervellati, F., Mureșan, X. M., Pessina, F., Lim, Y., Forman, H. J., & Valacchi, G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.007 · Cited by 32 · see citing works
Resveratrol Induces Long-Lasting IL-8 Expression and Peculiar EGFR Activation/Distribution in Human Keratinocytes: Mechanisms and Implications for Skin Administration
Pastore, S., Lulli, D., Maurelli, R., Dellambra, E., Luca, C. D., & Korkina, L. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059632 · Cited by 31 · see citing works
Dose response biology of resveratrol in obesity
Scapagnini, G., Davinelli, S., Kaneko, T., Koverech, G., Koverech, A., Calabrese, E. J., & Calabrese, V. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0257-3 · Cited by 31 · see citing works
Self-citation
Synergistic Effect of L-Carnosine and EGCG in the Prevention of Physiological Brain Aging
Davinelli, S., Marco, R. D., Bracale, R., Quattrone, A., Zella, D., & Scapagnini, G. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319150007 · Cited by 30 · see citing works
Self-citation
Topical treatment of green tea polyphenols emulsified in carboxymethyl cellulose protects against acute ultraviolet light B-induced photodamage in hairless mice
Li, H., Jiang, N., Liu, Q., Gao, A., Zhou, X., Liang, B., Li, R., Li, Z., & Zhu, H. (2016) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00073h · Cited by 20 · see citing works
Green tea in dermatology.
Pazyar, N., Feily, A., & Kazerouni, A. (2013) · PubMed · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review
Davinelli, S., Nielsen, M. E., & Scapagnini, G. (2018) · Nutrients · doi:10.3390/nu10040522 · Cited by 473 · see citing works
Self-citation
Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging
Ansary, T. M., Hossain, M. R., Kamiya, K., Komine, M., & Ohtsuki, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083974 · Cited by 393 · see citing works
Antioxidants from Plants Protect against Skin Photoaging
Petruk, G., Del Giudice, R., Rigano, M. M., & Monti, D. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1454936 · Cited by 283 · see citing works
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works

Authors: Davinelli, S., Bertoglio, J. C., Polimeni, A., & Scapagnini, G.
Affiliations: University of Molise (IT)
Department of Medicine, Hospital Clinico Regional de Valdivia, Valdivia, Chile
ReGenera Research Group, Milano, Italy
Corresponding author: Davinelli, Sergio
ORCID: Davinelli, Sergio
Scapagnini, Giovanni
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2018-04-05
Volume: 24
Issue: 2
Pages: 99-105
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/1381612823666171109102426
OpenAlex: W2767482921
Cited by: 57
References: 81
Citations by year: 2025: 9 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 3
FWCI: 7.34
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: polyphenols, skin aging, photoaging, photoprotection, antioxidant activity, anti-inflammatory activity, collagen degradation, procollagen synthesis, skin homeostasis, nutricosmetics
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Humans, Photosensitivity Disorders, Ultraviolet Rays, Skin Aging, Photosensitizing Agents, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks