Concentrations of Glucagon and the Insulin: Glucagon Ratio in the Portal and Peripheral Circulation
Abstract
SummaryIn postoperative patients studied in the postabsorptive state by mean of an umbilical vein catheter, concentrations of glucagon and insulin in portal blood exceeded those in peripheral venous blood. However, the portal—peripheral gradient for insulin (1.8-4.0) was consistently greater than that observed for glucagon (1.1-1.5). Consequently, the insulin:glucagon (I/G) molar ratio in the portal vein was 100% higher than in peripheral blood. A direct linear correlation however, was observed between portal and peripheral I/G molar ratios. The data indicate that peripheral measurements underestimate the absolute ratio of insulin to glucagon in portal blood, but nevertheless provide an index of relative hormonal availability in the hepatic circulation.
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Because the normal hepatic portal-to-peripheral venous insulin concentration ratio is ~2.5:1.0, the mild peripheral hyperinsulinemia during somatostatin with insulin likely produced portal hypoinsulinemia.
“Since the normal hepatic portal-to-peripheral venous insulin concentration ratio is ~2.5:1.0 (29–32), this mild peripheral hyper-nsn n s s sn ns linemia.”
From Epinephrine supports the postabsorptive plasma glucose concentration and prevents hypoglycemia when glucagon secretion is deficient in man (1984) · cites this paper as [29]
The portal venous to peripheral venous plasma glucagon ratio is approximately 1.5:1 in humans.
“The portal venous to peripheral venous plasma glucagon ratio is ~1.5:1 in humans (14-16)”
The hepatic portal venous to peripheral venous insulin ratio is normally approximately 2.5:1.
“since the hepatic portal venous to peripheral venous insulin ratio is normally ~2.5:1 (14-16)”
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- Authors
- Felig, P., Gusberg, R., Hendler, R., Gump, F. E., & Kinney, J. M.
- Affiliations
- Yale University (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1974-10-01
- Volume
- 147
- Issue
- 1
- Pages
- 88-90
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2009741645
- Cited by
- 91
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 2 · 2016: 2
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- glucagon, insulin, insulin/glucagon ratio, portal vein, peripheral venous blood, postabsorptive state, postoperative patients, umbilical venous catheter, hepatic blood flow
- MeSH terms
- Aged, Arm, Castration, Catheterization, Cholecystectomy, Female, Glucagon, Humans, Insulin, Laparotomy, Male, Middle Aged, Portal System, Portal Vein, Regional Blood Flow, Umbilical Veins, Veins
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