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Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo
Abstract
A novel carrier system for the delivery of chemotherapeutic agents by magnetic means to desired sites has been developed. Results indicate that the carrier, albumin microspheres with entrapped Fe3O4, and adriamycin HCl, can be concentrated at a predetermined site in vivo by a magnetic field. Carrier delivery of adriamycin is supported by the presence of a significant concentration of the drug at the site of carrier localization. This delivery system allows for the accumulation of local adriamycin which is comparable to that achieved by administration of a 100-fold higher dose of the free drug.
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Citations
Cited by
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583
Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Estelrich, J., Escribano, E., Queralt, J., & Busquets, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048070 · Cited by 532
New forms of superparamagnetic nanoparticles for biomedical applications
Xu, C., & Sun, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.008 · Cited by 349
Chourpa, I., Douziech-Eyrolles, L., Ngaboni-Okassa, L., Fouquenet, J.-F., Cohen-Jonathan, S., Soucé, M., Marchais, H., & Dubois, P. (2005) · The Analyst · doi:10.1039/b419004a · Cited by 344
Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
Monteserín, M., Larumbe, S., Martínez, A. V., Burgui, S., & Francisco Martín, L. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19062 · Cited by 27
Metadata
- Authors
- Widder, K. J., Senyei, A. E., & Scarpelli, D. G.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1978-06-01
- Volume
- 158
- Issue
- 2
- Pages
- 141-146
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2130977758
- Cited by
- 454
- References
- 0
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo. https://app.cochat.ai/papers/10.3181/00379727-158-40158
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- Widder, K. J., Senyei, A. E., & Scarpelli, D. G. (1978). Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-158-40158
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
