Cited by 241Pneumocystis jirovecii pneumonia detection and treatmentParasitic Infections and DiagnosticsPneumonia and Respiratory Infections

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Genetic Variation in Pneumocystis carinii Isolates from Different Geographic Regions: Implications for Transmission

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Beard, Charles B., Carter, Jane L., Keely, Scott P., Huang, Laurence, Pieniazek, Norman J., Moura, Iaci N.S., Roberts, Jacquelin M., Hightower, Allen W., Bens, Michelle S., Freeman, Amanda R., Lee, Sherline, Stringer, James R., Duchin, Jeffrey S., del Rio, Carlos, Rimland, David, Baughman, Robert P., Levy, Deborah A., Dietz, Vance J., Simon, Paul, Navin, Thomas R.·2000·Emerging infectious diseases

DOI 10.3201/eid0603.000306PMC PMC2640877

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Abstract

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do not result from infections acquired early in life, that infections are actively acquired from a relatively common source (humans or the environment), and that humans, while not necessarily involved in direct infection of other humans, are nevertheless important in the transmission cycle of P. carinii f. sp. hominis.

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Authors: Beard, C. B., Carter, J. L., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N. S., Roberts, J. M., Hightower, A. W., Bens, M. S., Freeman, A. R., Lee, S., Stringer, J. R., Duchin, J. S., del Rio, C., Rimland, D., Baughman, R. P., Levy, D. A., Dietz, V. J., Simon, P., & Navin, T. R.
Affiliations: Centers for Disease Control and Prevention (US)
Corresponding author: Beard, Charles B.
ORCID: Keely, Scott P.
Hightower, Allen W.
Venue: Emerging infectious diseases
Publisher: Centers for Disease Control and Prevention (CDC)
Published: 2000-06
Volume: 6
Issue: 3
Pages: 265-272
ISSN: 1080-6040 (ISSN-L)
1080-6059
DOI: 10.3201/eid0603.000306
PMC: PMC2640877
OpenAlex: W2101933645
Cited by: 241
References: 52
Citations by year: 2026: 2 · 2025: 3 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 9 · 2012: 18
FWCI: 10.74
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Emerging infectious diseases (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DigitalCommons@UNMC (submittedVersion, public-domain)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords: Pneumocystis carinii, Pneumocystis carinii pneumonia, AIDS, genetic variation, multilocus genotypes, mitochondrial large subunit rRNA, dihydropteroate synthase, transmission, co-infection, primary infection, birthplace, human reservoir
MeSH terms: Dihydropteroate Synthase, Gene Frequency, Genotype, Humans, Mitochondria, Pneumocystis, Pneumonia, Pneumocystis, RNA, Ribosomal, United States, Genetic Variation, Logistic Models, AIDS-Related Opportunistic Infections, Sequence Analysis, DNA, DNA Primers, Genes, rRNA

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Genetic Variation in Pneumocystis carinii Isolates from Different Geographic Regions: Implications for Transmission

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