Long-Term Prognosis for Clinical West Nile Virus Infection
Open accessAbstract
Relatively little is known about the long-term prognosis for patients with clinical West Nile virus (WNV) infection. We conducted a study to describe the recovery of New York City residents infected during the 1999 WNV encephalitis outbreak. Patients were interviewed by telephone on self-perceived health outcomes 6, 12, and 18 months after WNV illness onset. At 12 months, the prevalence of physical, functional, and cognitive symptoms was significantly higher than that at baseline, including muscle weakness, loss of concentration, confusion, and lightheadedness. Only 37% achieved a full recovery by 1 year. Younger age at infection was the only significant predictor of recovery. Efforts aimed at preventing WNV infection should focus on elderly populations who are at increased risk for neurologic manifestations and more likely to experience long-term sequelae of WNV illness. More studies are needed to document the long-term sequelae of this increasingly common infection.
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Most WNE cases require rehabilitation.
“Most cases require rehabilitation [85, 86].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [85]
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Cites
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540 · see citing works
Principles and Practice of Infectious Diseases.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-818_5 · Cited by 12,045 · see citing works
The Outbreak of West Nile Virus Infection in the New York City Area in 1999
Nash, D., Mostashari, F., Fine, A. D., Miller, J. R., O’Leary, D. E., Murray, K. O., Huang, A., Rosenberg, A., Greenberg, A. J., Sherman, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106143442401 · Cited by 1,360 · see citing works
Self-citationCalisher, C. H., Karabatsos, N., Dalrymple, J. M., Shope, R. E., Porterfield, J. S., Westaway, E. G., & Brandt, W. E. (1989) · Journal of General Virology · doi:10.1099/0022-1317-70-1-37 · Cited by 889 · see citing works
Neurologic Manifestations and Outcome of West Nile Virus Infection
Sejvar, J. J. (2003) · JAMA · doi:10.1001/jama.290.4.511 · Cited by 648 · see citing works
Martin, D. A., Muth, D. A., Brown, T., et al. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.5.1823-1826.2000 · Cited by 478 · see citing works
Outbreak of West Nile-Like Viral Encephalitis -- New York, 1999
Nash, D. (1999) · Cited by 351 · see citing works
Self-citationRoehrig, J. T., Nash, D., Maldin, B., Labowitz, A., Martin, D. A., Lanciotti, R. S., & Campbell, G. L. (2003) · Emerging infectious diseases · doi:10.3201/eid0903.020531 · Cited by 290 · see citing works
Self-citationOutbreak of West Nile-like viral encephalitis--New York, 1999.
(1999) · PubMed · Cited by 227 · see citing works
Johnson, A. J., Martin, D. A., Karabatsos, N., et al. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.5.1827-1831.2000 · Cited by 213 · see citing works
Petersen, L. R. (2003) · JAMA · doi:10.1001/jama.290.4.524 · Cited by 191 · see citing works
A Poliomyelitis-like Syndrome from West Nile Virus Infection
Leis, A. A., Stokić, D. S., Polk, J. L., Dostrow, V. G., & Winkelmann, M. (2002) · New England Journal of Medicine · doi:10.1056/nejm2002c021587 · Cited by 175 · see citing works
Poliomyelitis Due to West Nile Virus
Glass, J. D., Samuels, O. B., & Rich, M. M. (2002) · New England Journal of Medicine · doi:10.1056/nejm200210173471616 · Cited by 127 · see citing works
Update: West Nile–Like Viral Encephalitis—New York, 1999
Prevention, C. F. D. C. A., & Nash, D. (1999) · JAMA · doi:10.1001/jama.282.18.1714 · Cited by 93 · see citing works
Self-citationWestern Equine and St. Louis Encephalitis
Finley, K. H., LONGSHORE, W. A., Palmer, R. J., Cook, R. E., & Riggs, N. (1955) · Neurology · doi:10.1212/wnl.5.4.233 · Cited by 43 · see citing works
Update: West Nile-like viral encephalitis--New York, 1999.
(1999) · PubMed · Cited by 30 · see citing works
Creech, W. B. (1977) · The Journal of Infectious Diseases · doi:10.1093/infdis/135.6.1014 · Cited by 24 · see citing works
FOLLOW-UP STUDIES OF THE 1933 ST. LOUIS EPIDEMIC OF ENCEPHALITIS
Bredeck, J. F. (1938) · JAMA · doi:10.1001/jama.1938.02790270017004 · Cited by 23 · see citing works
Follow-Up Studies of St. Louis Encephalitis in Florida: Sensorimotor Findings
Azar, G. J., Chappell, G. L., LAWTON, A. H., et al. (1966) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.56.7.1074 · Cited by 14 · see citing works
Powell, K. E. (1977) · JAMA · doi:10.1001/jama.1977.03270480034015 · Cited by 14 · see citing works
Broun, G. O. (1958) · Neurology · doi:10.1212/wnl.8.11.883-a · Cited by 12 · see citing works
ST. LOUIS ENCEPHALITIS: AGE ASPECTS OF 1962 EPIDEMIC IN PINELLAS COUNTY, FLORIDA
Azar, G. J., Bond, J. O., & LAWTON, A. H. (1966) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1966.tb05593.x · Cited by 7 · see citing works
Follow-up Studies of St. Louis Encephalitis in Florida
Azar, G. J., BOND, J. O., CHAPPELL, G. L., et al. (1965) · Annals of Internal Medicine · doi:10.7326/0003-4819-63-2-212 · Cited by 6 · see citing works
St. Louis Encephalitis Sequelae and Accidents
Azar, G. J., & LAWTON, A. H. (1966) · Public Health Reports (1896-1970) · doi:10.2307/4592664 · Cited by 2 · see citing works
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A complement–microglial axis drives synapse loss during virus-induced memory impairment
Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature · doi:10.1038/nature18283 · Cited by 671 · see citing works
Unexplained post-acute infection syndromes
Choutka, J., Jansari, V., Hornig, M., & Iwasaki, A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01810-6 · Cited by 604 · see citing works
Long-Term Clinical and Neuropsychological Outcomes of West Nile Virus Infection
Carson, P. J., Konewko, P., Wold, K. S., Mariani, P., Goli, S., Bergloff, P., & Crosby, R. D. (2006) · Clinical Infectious Diseases · doi:10.1086/506939 · Cited by 189 · see citing works
Neurological sequelae resulting from encephalitic alphavirus infection
Ronca, S. E., Dineley, K. T., & Paessler, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00959 · Cited by 157 · see citing works
West Nile Virus: Immunity and Pathogenesis
Lim, S. M., Koraka, P., Osterhaus, A. D. M. E., & Martina, B. E. E. (2011) · Viruses · doi:10.3390/v3060811 · Cited by 133 · see citing works
Long-Term Neurological Outcomes in West Nile Virus–Infected Patients: An Observational Study
Weatherhead, J. E., Miller, V. E., Garcia, M. N., Hasbun, R., Salazar, L., Dimachkie, M. M., & Murray, K. O. (2015) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.14-0616 · Cited by 118 · see citing works
Murray, K. O., Garcia, M. N., Rahbar, M. H., Martinez, D., Khuwaja, S. A., Arafat, R. R., & Rossmann, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102953 · Cited by 103 · see citing works
Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Samaan, Z., McDermid Vaz, S., Bawor, M., Potter, T. H., Eskandarian, S., & Loeb, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158364 · Cited by 42 · see citing works
- Authors
- Klee, A. L., Maldin, B., Edwin, B., Poshni, I., Mostashari, F., Fine, A., Layton, M., & Nash, D.
- Affiliations
- United States Department of Veterans Affairs (US)
- New York City Department of Health and Mental Hygiene (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Nash, Denis
- Venue
- Emerging Infectious Diseases
- Published
- 2004-08
- Volume
- 10
- Issue
- 8
- Pages
- 1405-1411
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC3320418
- OpenAlex
- W1973680902
- Cited by
- 207
- References
- 26
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 17 · 2013: 8 · 2012: 11
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Keywords
- West Nile virus, West Nile encephalitis, long-term prognosis, post-infectious sequelae, recovery, somatic symptoms, cognitive symptoms, functional disability, age at infection, older adults
- MeSH terms
- Activities of Daily Living, Adolescent, Adult, Aged, Aged, 80 and over, Cognition Disorders, Female, Hospitalization, Humans, Interviews as Topic, Male, Middle Aged, New York City, Prognosis, Time Factors, West Nile Fever, West Nile virus
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