Cited by 285Fungal Infections and StudiesPneumonia and Respiratory InfectionsActinomycetales infections and treatment

Coccidioidomycosis as a common cause of community-acquired pneumonia

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Valdivia, Lisa, Nix, David, Wright, Mark, Lindberg, Elizabeth, Fagan, Timothy, Lieberman, Donald, Stoffer, T'Prien, Ampel, Neil M. +1 more·2006·Emerging Infectious Diseases

Abstract

The early manifestations of coccidioidomycosis (valley fever) are similar to those of other causes of community-acquired pneumonia (CAP). Without specific etiologic testing, the true frequency of valley fever may be underestimated by public health statistics. Therefore, we conducted a prospective observational study of adults with recent onset of a lower respiratory tract syndrome. Valley fever was serologically confirmed in 16 (29%) of 55 persons (95% confidence interval 16%-44%). Antimicrobial medications were used in 81% of persons with valley fever. Symptomatic differences at the time of enrollment had insufficient predictive value for valley fever to guide clinicians without specific laboratory tests. Thus, valley fever is a common cause of CAP after exposure in a disease-endemic region. If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism.

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  • It is thought that around 25% of all community-acquired pneumonia in endemic regions is secondary to coccidioidomycosis.

    “However, it is thought that around 25% of all community-acquired pneumonia in endemic regions is secondary to coccidioidomycosis [135].”

    From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [135]

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1 of the 19 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [4]Lundergan LL, Kerrick SS, Galgiani JN. Coccidioidomycosis at a university outpatient clinic: a clinical description. In: Einstein HE, Catanzaro A, editors. Coccidioidomycosis. Proceedings of the Fourth International Conference. Washington: National Foundation for Infectious Diseases; 1985. p. 47–54.
  2. [7]Campion JM, Gardner M, Galgiani JN. Coccidioidomycosis (valley fever) in older adults: an increasing problem. Arizona Geriatrics Society Journal. 2003; 8: 3– 12.

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Authors
Valdivia, L., Nix, D., Wright, M., Lindberg, E., Fagan, T., Lieberman, D., Stoffer, T., Ampel, N. M., & Galgiani, J. N.
Affiliations
  • University of Arizona (US)
  • Arizona Community Physicians, Tucson, Arizona, USA
Corresponding author
Galgiani, John N.
Venue
Emerging Infectious Diseases
Published
2006-06
Volume
12
Issue
6
Pages
958-962
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
OpenAlex
W2131843801
Cited by
285
References
19
Citations by year
2026: 11 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 21 · 2021: 15 · 2020: 16 · 2019: 20 · 2018: 12 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 8 · 2012: 11
FWCI
10.78
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Emerging infectious diseases (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • U.S. Department of Health and Human Services
  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (P01AI061310, 1 PO 1AI061310-01)
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
Keywords
coccidioidomycosis, community-acquired pneumonia, Coccidioides, serological diagnosis, endemic areas, antimicrobial therapy, travel-associated infection
MeSH terms
Adult, Antibodies, Fungal, Arizona, Coccidioides, Coccidioidomycosis, Enzyme-Linked Immunosorbent Assay, Female, Immunodiffusion, Humans, Male, Middle Aged, Pneumonia, Prospective Studies, Community-Acquired Infections

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