Invasive Non- Aspergillus Mold Infections in Transplant Recipients, United States, 2001–2006
Open accessAbstract
Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.
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Among transplant recipients in the US who developed mucormycosis, white race was predominant (90.5%).
“Among transplant recipients in the US who developed mucormycosis, white race was predominant (90.5%) [96]”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [96]
Among transplant recipients in the US, the vast majority developing fusariosis (94.4%) or scedosporiosis (91.3%) were white.
“Among transplant recipients in the US, the vast majority developing fusariosis (94.4%) or scedosporiosis (91.3%) were white [96].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [96]
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- Authors
- Park, B. J., Pappas, P. G., Wannemuehler, K. A., Alexander, B. D., Anaissie, E. J., Andes, D. R., Baddley, J. W., Brown, J. M., Brumble, L. M., Freifeld, A. G., Hadley, S., Herwaldt, L., Ito, J. I., Kauffman, C. A., Lyon, G. M., Marr, K. A., Morrison, V. A., Papanicolaou, G., Patterson, T. F., Perl, T. M., Schuster, M. G., Walker, R., Wingard, J. R., Walsh, T. J., & Kontoyiannis, D. P.
- Affiliations
- Centers for Disease Control and Prevention (US)
- University of Alabama (US)
- Duke University (US)
- University of California, Irvine (US)
- University of Wisconsin–Madison (US)
- Mayo Clinic in Florida (US)
- Tufts University (US)
- University of Iowa (US)
- City Of Hope National Medical Center (US)
- Emory University (US)
- Johns Hopkins University (US)
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Mayo Clinic (US)
- National Institutes of Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Park, Benjamin J.
- ORCID
- Pappas, Peter G.
- Wannemuehler, Kathleen A.
- Alexander, Barbara D.
- Andes, David R.
- Baddley, John W.
- Brumble, Lisa M.
- Freifeld, Alison G.
- Hadley, Susan
- Herwaldt, Loreen
- Marr, Kieren A.
- Papanicolaou, Genovefa
- Patterson, Thomas F.
- Perl, Trish M.
- Schuster, Mindy G.
- Wingard, John R.
- Walsh, Thomas J.
- Kontoyiannis, Dimitrios P.
- Venue
- Emerging Infectious Diseases
- Published
- 2011-10
- Volume
- 17
- Issue
- 10
- Pages
- 1855-1864
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC3311117
- OpenAlex
- W2142544148
- Cited by
- 321
- References
- 37
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 31 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 25 · 2019: 28 · 2018: 17 · 2017: 24 · 2016: 21 · 2015: 22 · 2014: 31 · 2013: 17 · 2012: 13
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- public-domain
- Locations
- Emerging infectious diseases (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Enzon Pharmaceuticals
- Astellas Pharma
- Centers for Disease Control and Prevention (U01CI000286, 5u01ci000286-05)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
- Keywords
- mucormycosis, Mucorales, Fusarium, Scedosporium, hematopoietic cell transplant recipients, solid organ transplant recipients, invasive fungal infections, mortality, incidence
- MeSH terms
- Adult, Antifungal Agents, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mycoses, Opportunistic Infections, Transplantation, United States, Cohort Studies, Incidence
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