The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
Open accessAbstract
In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isolate of MERS-CoV and a transient, primarily upper respiratory tract infection developed in each of the 3 animals. Clinical signs of the MERS-CoV infection were benign, but each of the camels shed large quantities of virus from the upper respiratory tract. We detected infectious virus in nasal secretions through 7 days postinoculation, and viral RNA up to 35 days postinoculation. The pattern of shedding and propensity for the upper respiratory tract infection in dromedary camels may help explain the lack of systemic illness among naturally infected camels and the means of efficient camel-to-camel and camel-to-human transmission.
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Cites
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,735
Hospital outbreak of Middle East respiratory syndrome coronavirus
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van Boheemen, S., de Graaf, M., Lauber, C., Bestebroer, T. M., Raj, V. S., Zaki, A. M., Osterhaus, A. D. M. E., Haagmans, B. L., Gorbalenya, A. E., Snijder, E. J., et al. (2012) · mBio · doi:10.1128/mbio.00473-12 · Cited by 914
Evidence for Camel-to-Human Transmission of MERS Coronavirus
Azhar, E. I., El-Kafrawy, S. A., Farraj, S. A., Hassan, A. M., Al-Saeed, M. S., Hashem, A. M., & Madani, T. A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401505 · Cited by 905
Reusken, C. B., Haagmans, B. L., Müller, M. A., Gutierrez, C., Godeke, G.-J., Meyer, B., Muth, D., Raj, V. S., Vries, L. S.-D., Corman, V. M., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70164-6 · Cited by 734
Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia
Memish, Z. A., Mishra, N., Olival, K. J., Fagbo, S. F., Kapoor, V., Epstein, J. H., AlHakeem, R., Durosinloun, A., Al Asmari, M., Islam, A., et al. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1911.131172 · Cited by 716
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
Haagmans, B. L., Al Dhahiry, S. H. S., Reusken, C. B. E. M., Raj, V. S., Galiano, M., Myers, R., Godeke, G.-J., Jonges, M., Farag, E., Diab, A., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70690-x · Cited by 671
A decade after SARS: strategies for controlling emerging coronaviruses
Graham, R. L., Donaldson, E. F., & Baric, R. S. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3143 · Cited by 655
Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
Alagaili, A. N., Briese, T., Mishra, N., Kapoor, V., Sameroff, S. C., de Wit, E., Munster, V. J., Hensley, L. E., Zalmout, I. S., Kapoor, A., et al. (2014) · mBio · doi:10.1128/mbio.00884-14 · Cited by 476
Self-citationDrosten, C., Seilmaier, M., Corman, V. M., Hartmann, W., Scheible, G., Sack, S., Guggemos, W., Kallies, R., Muth, D., Junglen, S., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70154-3 · Cited by 387
Cited by
SARS and MERS: recent insights into emerging coronaviruses
de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.81 · Cited by 3,510
Self-citationLetko, M., Marzi, A., & Munster, V. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0688-y · Cited by 3,109
Self-citationChannappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524
Bat-borne virus diversity, spillover and emergence
Letko, M., Seifert, S. N., Olival, K. J., Plowright, R. K., & Munster, V. J. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0394-z · Cited by 553
Self-citationLi, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K., & McCray, P. B. (2016) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv499 · Cited by 459
Metadata
- Authors
- Adney, D. R., van Doremalen, N., Brown, V. R., Bushmaker, T., Scott, D., de Wit, E., Bowen, R. A., & Munster, V. J.
- Venue
- Emerging Infectious Diseases
- Published
- 2014-12
- Volume
- 20
- Issue
- 12
- Pages
- 1999-2005
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W2132040786
- Cited by
- 285
- References
- 28
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Adney, D. R., van Doremalen, N., Brown, V. R., Bushmaker, T., Scott, D., de Wit, E., Bowen, R. A., & Munster, V. J. (2014). Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels. Emerging Infectious Diseases. https://doi.org/10.3201/eid2012.141280
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
