Signs or symptoms of acute HIV infection in a cohort undergoing community-based screening.
Open accessAbstract
We analyzed signs and symptoms in 90 patients diagnosed with acute HIV infection in a community-based program that offered universal HIV-1 nucleic acid amplification testing. Forty-seven (52%) patients reported ongoing signs or symptoms at the time of testing. Another 25 (28%) reported signs or symptoms that had occurred during the 14 days before testing.
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Most persons experience at least one symptom of acute HIV infection; however, some might be asymptomatic or have no recognition of illness.
“Most persons experience at least one symptom; however, some might be asymptomatic or have no recognition of illness (406–409).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [409]
The Conclusions report that 80% of participants had signs or symptoms within two weeks before testing, and The Study reports six asymptomatic patients. The paper also says symptoms are frequently not recognized as an indicator of acute HIV infection. However, all cases in this cohort were among men who have sex with men, and the Conclusions caution that the results may not apply to other populations; the claim’s broader reference to “most persons” goes beyond that finding. (LLM, conf=0.85)
Experimental — accuracy not yet measuredInfection with HIV causes an acute but brief and nonspecific influenza-like retroviral syndrome that can include fever, malaise, lymphadenopathy, pharyngitis, arthritis, or skin rash.
“Infection with HIV causes an acute but brief and nonspecific influenza-like retroviral syndrome that can include fever, malaise, lymphadenopathy, pharyngitis, arthritis, or skin rash.”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [409]
In The Study (Tables 1–2; page not provided), symptoms of acute HIV infection lasted a median of about 8–9 days and included fever, fatigue, pharyngitis, rash, and arthralgia. The paper does not report lymphadenopathy or arthritis; arthralgia means joint pain, not arthritis. Its findings also come from a cohort entirely of men who have sex with men. (LLM, conf=0.86)
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- Authors
- Hoenigl, M., Green, N., Camacho, M., Gianella, S., Mehta, S. R., Smith, D. M., & Little, S. J.
- Corresponding author
- Hoenigl, Martin
- Venue
- Emerging infectious diseases
- Published
- 2016-02
- Volume
- 22
- Issue
- 3
- Pages
- 532-534
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC4766914
- OpenAlex
- W2408540832
- Cited by
- 54
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 10
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (AI106039)
- Gilead Sciences (AI106039)
- ViiV Healthcare
- Max Kade Foundation
- National Institutes of Health (AI074621)
- National Institute of Mental Health (R01MH100974, MH100974, R25MH081482, P30MH062512)
- National Institute on Drug Abuse (P50DA026306)
- National Institute of Allergy and Infectious Diseases (R24AI106039, R21AI108351, AI093163, AI-043638, AI074621, U01AI043638, AI106039, P01AI074621, AI108351, K23AI093163)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- acute HIV infection, HIV-1, signs and symptoms, HIV screening, nucleic acid amplification tests, community-based testing, early HIV diagnosis
- MeSH terms
- Acute Disease, Adolescent, Adult, Aged, California, Female, Humans, Male, Mass Screening, Middle Aged, Cohort Studies, HIV-1, HIV Infections, Homosexuality, Male, CD4 Lymphocyte Count, Viral Load, Young Adult
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