Amoxicillin and ceftriaxone as treatment alternatives to penicillin for maternal syphilis.
Open accessAbstract
There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient.
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Data are insufficient to recommend ceftriaxone or other cephalosporins for treatment of maternal infection and prevention of congenital syphilis.
“Data are insufficient to recommend ceftriaxone or other cephalosporins for treatment of maternal infection and prevention of congenital syphilis (646,647).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [647]
The Conclusions say that data on ceftriaxone for treating maternal infection and preventing congenital syphilis are insufficient. They do not address other cephalosporins, and the authors nevertheless conclude that ceftriaxone should be considered as an alternative to penicillin; the source therefore does not fully support the claim that it cannot be recommended. (LLM, conf=0.88)
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- Authors
- Katanami, Y., Hashimoto, T., Takaya, S., Yamamoto, K., Kutsuna, S., Takeshita, N., Hayakawa, K., Kanagawa, S., & Ohmagari, N.
- Affiliations
- National Center for Global Health and Medicine (JP)
- Corresponding author
- Katanami, Yuichi
- ORCID
- Venue
- Emerging infectious diseases
- Published
- 2017-05
- Volume
- 23
- Issue
- 5
- Pages
- 827-829
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC5403051
- OpenAlex
- W2604817400
- Cited by
- 32
- References
- 13
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Center for Global Health and Medicine
- Topics
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- maternal syphilis, amoxicillin, ceftriaxone, probenecid, syphilis treatment
- MeSH terms
- Adult, Amoxicillin, Anti-Bacterial Agents, Ceftriaxone, Female, Humans, Infant, Newborn, Penicillin G Benzathine, Penicillins, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Syphilis, Treatment Outcome, Young Adult, Drug Substitution
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