The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma
Open accessAbstract
BACKGROUND: It has been shown that circular RNA (circRNA) is associated with human cancers, however, few studies have been reported in hepatocellular carcinoma (HCC). OBJECTIVE: To estimate clinical values of a circular RNA, Hsa_circ_0001649, in HCC. METHODS: Expression level of hsa_circ_0001649 was detected in HCC and paired adjacent liver tissues by real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs). Differences in expression level of hsa_circ_0001649 were analyzed using the paired t-test. Tests were performed between clinical information and hsa_circ_0001649 expression level by analysis of variance (ANOVA) or welch t-test and a receiver operating characteristics (ROC) curve was established to estimate the value of hsa_circ_0001649 expression as a biomarker in HCC. RESULTS: hsa_circ_0001649 expression was significantly downregulated in HCC tissues (p = 0.0014) based on an analysis of 89 paired samples of HCC and adjacent liver tissues and the area under the ROC curve (AUC) was 0.63. Furthermore, hsa_circ_0001649 expression was correlated with tumor size (p = 0.045) and the occurrence of tumor embolus (p = 0.017) in HCC. CONCLUSIONS: We first found hsa_circ_0001649 was significantly downregulated in HCC. Our findings indicate hsa_circ_0001649 might serve as a novel potential biomarker for HCC and may function in tumorigenesis and metastasis of HCC.
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Cites
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Natural RNA circles function as efficient microRNA sponges
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Self-citationcircRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Exon-intron circular RNAs regulate transcription in the nucleus
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Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
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Circular RNA: a new star of noncoding RNAs
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“It has been proposed that circRNAs may act as competing endogenous RNAs to bind proteins (protein sponges) [30,31].”
BackgroundExpanded identification and characterization of mammalian circular RNAs
Guo, J. U., Agarwal, V., Guo, H., & Bartel, D. P. (2014) · Genome biology · doi:10.1186/preaccept-1176565312639289 · Cited by 1,585
Hepatocellular carcinoma: clinical frontiers and perspectives
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Cited by
CircRNA: a novel type of biomarker for cancer
Zhang, H.-D., Jiang, L.-H., Sun, D.-W., Hou, J.-C., & Ji, Z.-L. (2018) · Breast Cancer · doi:10.1007/s12282-017-0793-9 · Cited by 760
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis
Zhang, M., Huang, N., Yang, X., Luo, J., Yan, S., Xiao, F., Chen, W., Gao, X., Zhao, K., Zhou, H., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0019-9 · Cited by 721
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546
Han, B., Zhang, Y., Zhang, Y., Bai, Y., Chen, X., Huang, R., Wu, F., Leng, S., Chao, J., Zhang, J. H., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1458173 · Cited by 360
Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer
Chen, B., & Huang, S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.011 · Cited by 308
Metadata
- Authors
- Qin, M., Liu, G., Huo, X., Tao, X., Sun, X., Ge, Z., Yang, J., Fan, J., Liu, L., & Qin, W.
- Venue
- Cancer Biomarkers
- Publisher
- SAGE Publications
- Published
- 2016-01-18
- Volume
- 16
- Issue
- 1
- Pages
- 161-169
- ISSN
- 1574-0153 (ISSN-L)
- 1875-8592
- OpenAlex
- W2204741763
- Cited by
- 441
- References
- 32
- FWCI
- 38.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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