CoChat
Sign Up
Cited by 97

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment

Xie, Bing, Zhou, Huimin, Zhang, Rui, Song, Mei, Yu, Lulu, Wang, Lan, Liu, Zanchao, Zhang, Qingfu, Cui, Dongsheng, Wang, Xueyi, Xu, Shunjiang·2015·Journal of Alzheimer's Disease
DOI 10.3233/jad-142847
Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. The present study was performed to investigate the potential role of circulating miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI). We collected 66 patients with MCI and 76 normal controls from our previous cross-sectional cohort study. Seven miRNAs (miR-206, miR-132, miR-193b, miR-130b, miR-20a, miR-296, and miR-329) related to Alzheimer's disease (AD) were detected in serum using a quantitative real-time PCR (qRT-PCR) method. Each miRNA's diagnostic performance was evaluated by receiver operating characteristic curves and the areas under curves (AUC) analysis. The levels of miR-206 and miR-132 in MCI patients' serum were significantly elevated compared to normal controls. Combining detection of miR-206 and miR-132 achieved the highest AUC of 0.981, followed by test of miR-206 (AUC = 0.880) and miR-132 (AUC = 0.912) separately. Importantly, miR-206 and miR-132 were respectively correlated with the Montreal Cognitive Assessment score in MCI patients. These results preliminarily indicated that circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI.

Overview

Integrity signals

Registry

Crossref · 10.3233/jad-142847

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 9 references

Cited by

Sorted by citations

See all 97

Metadata

Authors
Xie, B., Zhou, H., Zhang, R., Song, M., Yu, L., Wang, L., Liu, Z., Zhang, Q., Cui, D., Wang, X., & Xu, S.
Affiliations
  • Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Department of Endocrinology, The Second Hospital of Shijiazhuang City, Shijiazhuang, P.R. China
  • Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2015-03-24
Volume
45
Issue
3
Pages
721-731
ISSN
  • 1875-8908
  • 1387-2877
DOI
10.3233/jad-142847
Cited by
97
References
9

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. https://app.cochat.ai/papers/10.3233/jad-142847
The paper
Xie, B., Zhou, H., Zhang, R., Song, M., Yu, L., Wang, L., Liu, Z., Zhang, Q., Cui, D., Wang, X., & Xu, S. (2015). Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-142847