Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with 1 H-MRS at 0.5 T

Antuono, Piero G.; Jones, Jennifer L.; Wang, Yonker; Li, Shi-Jiang

doi:10.1212/wnl.56.6.737

Cited by 119Dementia and Cognitive Impairment ResearchAdvanced MRI Techniques and ApplicationsAlzheimer's disease research and treatments

Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with 1 H-MRS at 0.5 T

Antuono, Piero G., Jones, Jennifer L., Wang, Yonker, Li, Shi-Jiang·2001·Neurology

DOI 10.1212/wnl.56.6.737

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Abstract

OBJECTIVE: To determine whether glutamate + glutamine (GLX) levels in the brain as measured in vivo with proton MRS at 0.5 tesla (T) distinguish between probable Alzheimer's disease and normal aging. BACKGROUND: Glutamatergic markers had been measured previously in postmortem brain tissue. Conventional proton MRS at 1.5 T cannot reliably detect the GLX resonance in vivo. The authors developed a technique at 0.5 T that is sensitive to the GLX resonance. METHODS: Metabolite ratios using creatine and phosphocreatine resonance as an internal standard were acquired from the cingulate region of 18 patients with AD and 12 healthy controls. The major resonances in the spectrum were examined: N-acetylaspartate (NAA), choline-containing compounds, myo-inositol, and GLX. The Mini-Mental State Examination (MMSE) was used to assess cognitive status. The Instrumental Activities of Daily Living Scale (Instrumental ADL) was used to assess functional status. RESULTS: Reduced ratios of GLX (-10%, p = 0.001) and NAA (-12%, p = 0.000) were found in patients with AD. Increased ratios of myo-inositol in patients with AD approached significance (+14%). GLX ratios of patients with AD were correlated with MMSE (r = 0.61, p = 0.007) and Instrumental ADL (r = 0.59, p = 0.01) scores. The combined sensitivity of NAA and myo-inositol in correctly diagnosing AD was 78%. The addition of GLX to NAA and myo-inositol increased the sensitivity to 89%. Overall diagnostic accuracy improved from 80 to 83% with the addition of GLX. CONCLUSIONS: Glutamate + glutamine reduction may be a biologic marker for AD and may be a potential aid in the early clinical diagnosis of AD.

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Concentrations of Glu are lower in the posterior cingulate cortex of AD patients, either when measured alone or as a combined measure of Glu+glutamine (Glx).
“Concentrations of Glu were also shown to be lower in the posterior cingulate cortex of AD patients, either when measured alone or as a combined measure of Glu+glutamine (Glx) (Antuono et al. 2001; Fayed et al. 2011; Rupsingh et al. 2011).”
From Alzheimer’s disease: Targeting the glutamatergic system (2020) · cites this paper as Antuono et al. 2001

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works
Functional Heterogeneity in Cingulate Cortex: The Anterior Executive and Posterior Evaluative Regions
Vogt, B. A., Finch, D. M., & Olson, C. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.6.435-a · Cited by 1,315 · see citing works
Pathological verification of ischemic score in differentiation of dementias
Rosen, W. G., Terry, R. D., Fuld, P. A., Katzman, R., & Peck, A. (1980) · Annals of Neurology · doi:10.1002/ana.410070516 · Cited by 1,273 · see citing works
Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
Novelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961 · see citing works
Multinuclear NMR Studies on the Energy Metabolism of Glial and Neuronal Cells
Brand, A., Richter‐Landsberg, C., & Leibfritz, D. (1994) · Developmental Neuroscience · doi:10.1159/000111347 · Cited by 889 · see citing works
NMDA Antagonist Neurotoxicity: Mechanism and Prevention
Olney, J. W., Labruyere, J., Wang, G., Wozniak, D. F., Price, M. T., & Sesma, M. A. (1991) · Science · doi:10.1126/science.1835799 · Cited by 841 · see citing works
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms
Szatkowski, M. S., & Attwell, D. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90040-x · Cited by 625 · see citing works
Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
Brun, A., & Englund, E. M. (1981) · Histopathology · doi:10.1111/j.1365-2559.1981.tb01818.x · Cited by 559 · see citing works
Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
Davie, C. A., Hawkins, C. P., Barker, G. J., Brennan, A., Tofts, P. S., Miller, D. H., & McDonald, W. I. (1994) · Brain · doi:10.1093/brain/117.1.49 · Cited by 536 · see citing works
Retrosplenial amnesia
VALENSTEIN, E., BOWERS, D., VERFAELLIE, M., HEILMAN, K. M., DAY, A., & WATSON, R. T. (1987) · Brain · doi:10.1093/brain/110.6.1631 · Cited by 487 · see citing works
Excitatory amino acids and Alzheimer's disease
Greenamyre, J. T., & Young, A. B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90143-7 · Cited by 482 · see citing works
Contributions of cingulate cortex to two forms of spatial learning and memory
Sutherland, R., Whishaw, I., & Kolb, B. E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01863.1988 · Cited by 424 · see citing works
Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.
Kreis, R., Ross, B. D., Farrow, N. A., & Ackerman, Z. (1992) · Radiology · doi:10.1148/radiology.182.1.1345760 · Cited by 351 · see citing works
Probable Alzheimer disease: diagnosis with proton MR spectroscopy.
Shonk, T. K., Moats, R. A., Gifford, P., Michaelis, T., Mandigo, J. C., Izumi, J., & Ross, B. D. (1995) · Radiology · doi:10.1148/radiology.195.1.7892497 · Cited by 299 · see citing works
Abnormal cerebral metabolite concentrations in patients with probable alzheimer disease
Moats, R. A., Ernst, T. M., Shonk, T. K., & Ross, B. D. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320115 · Cited by 216 · see citing works
Use of the Cornell Scale in Nondemented Patients
Alexopoulos, G. S., Abrams, R. C., Young, R. C., & Shamoian, C. A. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb01806.x · Cited by 199 · see citing works
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
Ernst, T., Chang, L., Melchor, R., & Mehringer, C. M. (1997) · Radiology · doi:10.1148/radiology.203.3.9169712 · Cited by 192 · see citing works
Total brain N -acetylaspartate
Gonen, O., Catalaa, I., Babb, J. S., Ge, Y., Mannon, L. J., Kolson, D. L., & Grossman, R. I. (2000) · Neurology · doi:10.1212/wnl.54.1.15 · Cited by 182 · see citing works
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging
Meyerhoff, D. J., MacKay, S., Constans, J., Norman, D. M., Dyke, C. V., Fein, G., & Weiner, M. W. (1994) · Annals of Neurology · doi:10.1002/ana.410360110 · Cited by 160 · see citing works
Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo1H magnetic resonance spectroscopy
Wang, Y., & Li, S. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390107 · Cited by 136 · see citing works
Self-citation
1H-MRS evidence of neurodegeneration and excess glutamate glutamine in ALS medulla
Pioro, E. P., Majors, A. W., Mitsumoto, H., Nelson, D. R., & Ng, T. C. (1999) · Neurology · doi:10.1212/wnl.53.1.71 · Cited by 132 · see citing works
Localized pontine 1esion
Lavie, P., Pratt, H., Scharf, B., Peled, R., & Brown, J. (1984) · Neurology · doi:10.1212/wnl.34.1.118 · Cited by 129 · see citing works
4480228 Selective volume method for performing localized NMR spectroscopy
Bottomley, P. A. (1985) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(85)90032-3 · Cited by 123 · see citing works
Proton spectroscopy of human brain: Effects of age and sex
Charles, H. C., Lazeyras, F., Krishnan, K. R. R., Boyko, O. B., Patterson, L. J., Doraiswamy, P. M., & McDonald, W. M. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90125-2 · Cited by 112 · see citing works
Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging.
MacKay, S., Ezekiel, F., Sclafani, V. D., Meyerhoff, D. J., Gerson, J., Norman, D. M., Fein, G., & Weiner, M. W. (1996) · Radiology · doi:10.1148/radiology.198.2.8596863 · Cited by 105 · see citing works
Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain.
Klunk, W., Xu, C., Panchalingram, K., Mcclure, R., & Pettegrew, J. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00035-8 · Cited by 82 · see citing works
Brain Proton Magnetic Resonance Spectroscopy in HIV-Related Encephalopathy: Identification of Evolving Metabolic Patterns in Relation to Dementia and Therapy
Salvan, A.-M., Vion‐Dury, J., Sylviane Confort-gouny, A., Nicoli, F., Lamoureux, S., & Cozzone, P. J. (1997) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1997.13.1055 · Cited by 81 · see citing works
An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains
Mohanakrishnan, P., Fowler, A. H., Vonsattel, J. P., Husain, M. M., Jolles, P. R., Liem, P. H., & Komoroski, R. A. (1995) · Experimental Brain Research · doi:10.1007/bf00230654 · Cited by 62 · see citing works
A Proton Magnetic Resonance Spectroscopy Study of the Striatum and Cerebral Cortex in Parkinson's Disease
Taylor-Robinson, S. D., Turjanski, N., Bhattacharya, S., Seery, J. P., Sargentoni, J., Brooks, D. J., Bryant, D. J., & Cox, I. J. (1999) · Metabolic Brain Disease · doi:10.1023/a:1020609530444 · Cited by 54 · see citing works
Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease
Christiansen, P., Schlosser, A. E., & Henriksen, O. M. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)00113-h · Cited by 52 · see citing works
Regional Metabolic Alterations in Alzheimer's Disease: An in vitro 1H NMR Study of the Hippocampus and Cerebellum
Mohanakrishnan, P., Fowler, A. H., Paul, J., Jolles, P. R., Husain, M. M., Liem, P. H., Myers, L., & Komoroski, R. A. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b111 · Cited by 39 · see citing works
Detection of glutamate/glutamine resonances by 1H magnetic resonance spectroscopy at 0.5 tesla
Prost, R. W., Mark, L. P., Mewissen, M. W., & Li, S. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370422 · Cited by 38 · see citing works
Self-citation
Neural connections of auditory association cortex with the posterior cingulate cortex in the monkey
Yukie, M. (1995) · Neuroscience Research · doi:10.1016/0168-0102(95)00888-1 · Cited by 38 · see citing works
Electrolytic but not ibotenic acid lesions of the posterior cingulate cortex produce transitory facilitation of learning in mice
Meunier, M., & Destrade, C. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90041-1 · Cited by 35 · see citing works
Correction of phase effects produced by eddy currents in solvent suppressed 1H‐CSI
Roebuck, J. R., Hearshen, D., O’Donnell, M., & Raidy, T. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300302 · Cited by 28 · see citing works
In Vivo Proton Magnetic Resonance Spectroscopy for Metabolic Changes of Human Brain Edema
Kamada, K., Houkin, K., Iwasaki, Y., Hiroshi, A. B. E., & KASHIWABA, T. (1994) · Neurologia medico-chirurgica · doi:10.2176/nmc.34.676 · Cited by 23 · see citing works
Brain tumors: localized H-1 MR spectroscopy at 0.5 T.
Prost, R. W., Haughton, V. M., & Li, S. J. (1997) · Radiology · doi:10.1148/radiology.204.1.9205253 · Cited by 15 · see citing works
Self-citation
Untitled work
Christensen (1997) · doi:10.1002/(sici)1099-1166(199703)12:3

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Fayed, N. M., Andres, E. M., Viguera, L., Modrego, P. J., & García‐Campayo, J. (2014) · Academic Radiology · doi:10.1016/j.acra.2014.04.009 · Cited by 54 · see citing works
Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers
Dang, C., Wang, Y., Li, Q., & Lu, Y. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad009 · Cited by 53 · see citing works
Self-citation
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Jiang, Y., Long, L., ZHU, X., ZHENG, H., FU, X., OU, S., WEI, D., Zhou, H., & Zheng, W. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.07.009 · Cited by 53 · see citing works
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Mlynárik, V., Cacquevel, M., Sun-Reimer, L., Janssens, S., Cudalbu, C., Lei, H., Schneider, B. L., Aebischer, P., & Rolf Gruetter, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112072 · Cited by 52 · see citing works
Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
Agarwal, N., & Renshaw, P. F. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2587 · Cited by 51 · see citing works
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Saba, K., Rajnala, N., Veeraiah, P., Tiwari, V., Rana, R. K., Lakhotia, S. C., & Patel, A. B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00323 · Cited by 50 · see citing works
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Griffith, H. R., den Hollander, J. A., Stewart, C. C., Evanochko, W. T., Buchthal, S. D., Harrell, L. E., ZAMRINI, E. Y., Brockington, J. C., & Marson, D. C. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1132 · Cited by 48 · see citing works
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study
Waldman, A. D., & Rai, G. S. (2003) · Neuroradiology · doi:10.1007/s00234-003-1040-y · Cited by 48 · see citing works
Magnetic Resonance Spectroscopy in Common Dementias
Kantarci, K. (2013) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2012.10.004 · Cited by 47 · see citing works
Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy
Herminghaus, S., Frölich, L., Gorriz, C., Pilatus, U. U., Dierks, T., Wittsack, H., Lanfermann, H., Maurer, K., & Zanella, F. E. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00071-4 · Cited by 45 · see citing works
Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy
Ratai, E., Kok, T., Wiggins, C., Wiggins, G., Grant, E., Gagoski, B., O’Neill, G., Adalsteinsson, E., & Eichler, F. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1488 · Cited by 37 · see citing works
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Blamire, A. M. (2018) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2018.11.001 · Cited by 37 · see citing works
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 39 · see citing works
Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB‐PET Study
Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., et al. (2017) · Journal of Neuroimaging · doi:10.1111/jon.12454 · Cited by 37 · see citing works
Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies
Graff‐Radford, J., Boeve, B. F., Murray, M. E., Ferman, T. J., Tosakulwong, N., Lesnick, T. G., Maroney‐Smith, M., Senjem, M. L., Gunter, J. L., Smith, G. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.001 · Cited by 36 · see citing works
Single‐voxel 1 H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility
Allaïli, N., Valabrègue, R., Auerbach, E. J., Guillemot, V., Yahia‐Cherif, L., Bardinet, É., Jabourian, M., Fossati, P., Lehéricy, S., & Marjańska, M. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3364 · Cited by 34 · see citing works
Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization Study
Adams, C. D. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s239350 · Cited by 28 · see citing works
Memantine decreases hippocampal glutamate levels: A magnetic resonance spectroscopy study
Glodzik, L., King, K. G., Gonen, O., Liu, S., Santi, S. D., & de Leon, M. J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.016 · Cited by 28 · see citing works
Brain Metabolic Correlates of Decision Making in Amnestic Mild Cognitive Impairment
Griffith, H. R., Okonkwo, O. C., den Hollander, J. A., Belue, K., Copeland, J., Harrell, L. E., Brockington, J. C., Clark, D. G., & Marson, D. C. (2010) · Aging Neuropsychology and Cognition · doi:10.1080/13825581003646135 · Cited by 28 · see citing works
Meta-analysis of brain metabolite differences in HIV infection
Chelala, L., O’Connor, E. E., Barker, P. B., & Zeffiro, T. A. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102436 · Cited by 26 · see citing works
Imaging Biomarkers in Alzheimer’s Disease: A Practical Guide for Clinicians
Sheikh‐Bahaei, N., Sajjadi, S. A., Manavaki, R., & Gillard, J. H. (2017) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-170013 · Cited by 27 · see citing works
Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System
Wang, Q., Yang, C., Chen, S., & Li, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202406867 · Cited by 26 · see citing works
Chapter 6 Proton Magnetic Resonance Spectroscopy In Dementias And Mild Cognitive Impairment
Griffith, H. R., Stewart, C. C., & den Hollander, J. A. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)00406-1 · Cited by 25 · see citing works
Proton Magnetic Resonance Spectroscopy of the Hippocampus in Patients With Mild Cognitive Impairment
Franczak, M. B., Prost, R. W., Antuono, P., Mark, L. P., Jones, J. L., & Ulmer, J. L. (2007) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0b013e318031bc31 · Cited by 25 · see citing works
Self-citation
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Forster, D. M., Davies, K. E., & Williams, S. R. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24349 · Cited by 23 · see citing works
Alzheimer-like brain metabolic and structural features in cholesterol-fed rabbit detected by magnetic resonance imaging
Jin, P., Pan, Y., Pan, Z., Xu, J., Lin, M. T., Sun, Z., Chen, M., & Xu, M. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0705-9 · Cited by 22 · see citing works
Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice
Gao, J., Zhou, N., Wu, Y., Lu, M., Wang, Q., Xia, C., Zhou, M., & Xu, Y. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03032-9 · Cited by 20 · see citing works
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Orzyłowska, A., & Oakden, W. (2021) · Brain Sciences · doi:10.3390/brainsci12010053 · Cited by 20 · see citing works
3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging
Nikolova, S., Stark, S. M., & Stark, C. E. L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.026 · Cited by 21 · see citing works
Decreased glutamine and glutamate: an early biomarker of neurodegeneration
Zeydan, B., & Kantarci, K. (2021) · International Psychogeriatrics · doi:10.1017/s1041610219001807 · Cited by 20 · see citing works
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van Erp, S. J. H., Ercan, E., Breedveld, P., Brakenhoff, L. K. P. M., Ghariq, E., Schmid, S., van Osch, M. J. P., van Buchem, M. A., Emmer, B. J., van der Grond, J., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i6.1018 · Cited by 20 · see citing works
A Review of Glutamate Receptors II: Pathophysiology and Pathology
Rousseaux, C. G. (2008) · Journal of Toxicologic Pathology · doi:10.1293/tox.21.133 · Cited by 19 · see citing works
Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease
Bellanti, F., Bukke, V. N., Moola, A., Villani, R., Scuderi, C., Steardo, L., Palombelli, G., Canese, R., Beggiato, S., Altamura, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.890855 · Cited by 18 · see citing works
The relationship between measurement of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults
Burger, A., Kotze, M. J., Stein, D. J., van Rensburg, S. J., & Howells, F. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14583 · Cited by 17 · see citing works
Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease
Chen, Q., Abrigo, J., Liu, W., Han, E. Y., Yeung, D. K. W., Shi, L., Au, L. W. C., Deng, M., Chen, S., Leung, E. Y. L., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12060722 · Cited by 15 · see citing works
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de León-López, C. A. M., Navarro‐Lobato, I., & Khan, Z. U. (2025) · Biomolecules · doi:10.3390/biom15070910 · Cited by 19 · see citing works
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
Hinteregger, B., Loeffler, T., Flunkert, S., Neddens, J., Bayer, T., Madl, T., & Hutter-Paier, B. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-201204 · Cited by 11 · see citing works
Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation
Marizzoni, M., Mombelli, E., Alboni, S., Rosa, M., Moretti, D. V., Mirabelli, P., Coppola, L., Luongo, D., Salamone, D., Saleri, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106138 · Cited by 14 · see citing works
Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging
Wang, X., Yang, X., Hou, Z., Tian, S., Xu, G., Li, J., Wen, L., Bi, D., Gao, F., Shen, Y., et al. (2022) · Talanta · doi:10.1016/j.talanta.2022.124046 · Cited by 14 · see citing works
Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease
Sheikh‐Bahaei, N., Chen, M., & Pappas, I. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3774-6_9 · Cited by 14 · see citing works
1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease
Doert, A., Pilatus, U., Zanella, F., Müller, W. E. G., & Eckert, G. P. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1387-3 · Cited by 14 · see citing works
Glutamine as a Potential Neuroprotectant in Alzheimer’s Disease
Chen, J., & Herrup, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00070-7 · Cited by 11 · see citing works
Causal Associations Between Gut Microbiota, Gut Microbiota-Derived Metabolites, and Alzheimer’s Disease: A Multivariable Mendelian Randomization Study
Ning, M., An, L., Dong, L., Zhu, R., Hao, J., Liu, X., & Zhang, Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240082 · Cited by 11 · see citing works
Brain Proton MRS is Correlated with Financial Abilities in Patients with Alzheimer’s Disease
Griffith, H. R., Okonkwo, O. C., den Hollander, J. A., Belue, K., Lanza, S., Harrell, L. E., Brockington, J. C., Clark, D. G., & Marson, D. C. (2007) · Brain Imaging and Behavior · doi:10.1007/s11682-007-9002-3 · Cited by 11 · see citing works
Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes Using Alzheimer’s Disease Biofluid, PET, Postmortem Pathology Biomarkers, and APOE Genotype
Kara, F., & Kantarci, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810064 · Cited by 10 · see citing works
Glutamatergic and GABAergic metabolite levels in Alzheimer’s disease: a systematic review and meta-analysis
Ebrahimi, R., Soltani, S. M., Masouri, M. M., Seifi, M., Ghafourian, K., & Noori, S. (2025) · BMC Neurology · doi:10.1186/s12883-025-04375-2 · Cited by 11 · see citing works
Metabolomics and mitochondrial dysfunction in Alzheimer’s disease
Kim, D., Gim, J., Yoon, D., Kim, S., & Kim, H. (2016) · Genes & Genomics · doi:10.1007/s13258-016-0494-3 · Cited by 8 · see citing works
MR spectroscopy in Alzheimer’s disease
Sheikh‐Bahaei, N. (2020) · Biomedical Spectroscopy and Imaging · doi:10.3233/bsi-200194 · Cited by 8 · see citing works
Clinical Biomarkers and Novel Drug Targets to Cut Gordian Knots of Alzheimer's Disease
Mir, R. H., Masoodi, M. H., Shah, A. J., Mohi-ud-din, R., Sabreen, S., Wani, T. U., Jan, R., Javed, M. N., & Mir, P. A. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220903095837 · Cited by 6 · see citing works
Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly
Motegi, T., Narita, K., Fujihara, K., Kasagi, M., Suzuki, Y., Tagawa, M., Ujita, K., Near, J., & Fukuda, M. (2019) · International Psychogeriatrics · doi:10.1017/s1041610219001418 · Cited by 6 · see citing works
Retrospective analysis of Braak stage– and APOE4 allele–dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly
Chen, A. M., Gajdošík, M., Ahmed, W., Ahn, S., Babb, J. S., Blessing, E., Boutajangout, A., de Leon, M. J., Debure, L., Gaggi, N. L., et al. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120742 · Cited by 5 · see citing works
DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments
Ding, Q., Yu, Q., Lei, T., Guo, Y., Zhao, J., & Yu, J. J. (2022) · STEMedicine · doi:10.37175/stemedicine.v3i1.113 · Cited by 5 · see citing works
Neuroimaging of Alzheimer’s Disease, Mild Cognitive Impairment, and Other Dementias
Risacher, S. L., & Saykin, A. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_19 · Cited by 5 · see citing works
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity
Górska, A. M., Santos‐García, I., Kvasnička, A., Dobešová, D., Friedecký, D., Gildenblat, J., & Pahnke, J. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102891 · Cited by 5 · see citing works
The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset
Cheung, N. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261433953 · Cited by 4 · see citing works
Amyloid pathology induces dysfunction of systemic neurotransmission in aged APPswe/PS2 mice
Oh, S. J., Lee, N., Nam, K. R., Kang, K. J., Han, S. J., Lee, K. C., Lee, Y. J., & Choi, J. Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.930613 · Cited by 4 · see citing works
The Glutamatergic System in Alzheimer’s Disease Brain: Dysfunction Associated with Amyloid β-Peptide and Oxidative Stress
Butterfield, D. A. (2004) · Springer eBooks · doi:10.1007/978-1-4419-8959-8_14 · Cited by 3 · see citing works
Effect of ceftriaxone on the glutamate-glutamine cycle and seizure susceptibility of Tg2576 mouse model of Alzheimer's disease
Dejakaisaya, H., Lin, R., Harutyunyan, A., Chan, J., Kwan, P., & Jones, N. C. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241289053 · Cited by 3 · see citing works
Magnetic Resonance Spectroscopy in Dementia
Graff‐Radford, J., & Kantarci, K. (2016) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-33555-1_4 · Cited by 3 · see citing works
Optimized multi-voxel TE-averaged PRESS for glutamate detection in the human brain at 3T
Hatay, G. H., & Öztürk-Işık, E. (2023) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2023.107574 · Cited by 3 · see citing works
Currently Available Neuroimaging Approaches in Alzheimer Disease (AD) Early Diagnosis
Ortiz-Terán, L., Juan, M. R., Martin, M. D. L. N. C., & Ortiz, T. (2011) · InTech eBooks · doi:10.5772/17012 · Cited by 3 · see citing works
Wavelet-based Image Fusion for Enhancement of ROI in CT Image
Hải, N. T. (2014) · Journal of Biomedical Engineering and Medical Imaging · doi:10.14738/jbemi.14.310 · Cited by 3 · see citing works

Proton MRS investigation of glutamate in Alzheimer's disease
Ningnanna, Z. (2014) · International Journal of Medical Radiology
Imaging of glutamate neurotransmitter alterations in Alzheimer's disease
Haris, M., Nath, K., Cai, K., Singh, A. K., Crescenzi, R. L., Kogan, F., Verma, G., Reddy, S., Hariharan, H., Melhem, E. R., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2875 · Cited by 147 · see citing works
High performance liquid chromatography determination of l-glutamate, l-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer’s disease
Nuzzo, T., Mancini, A., Miroballo, M., Casamassa, A., Maio, A. D., Donati, G., Sansone, G., Gaetani, L., Paoletti, F. P., Isidori, A. M., et al. (2021) · Amino Acids · doi:10.1007/s00726-021-02943-7 · Cited by 36 · see citing works
Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment
Huang, D., Liu, D., Yin, J., Qian, T., Shrestha, S., & Ni, H. (2016) · European Radiology · doi:10.1007/s00330-016-4669-8 · Cited by 127 · see citing works
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer’s disease
Hattori, N., Abe, K., Sakoda, S., & Sawada, T. (2002) · Neuroreport · doi:10.1097/00001756-200201210-00041 · Cited by 112 · see citing works

Authors: Antuono, P. G., Jones, J. L., Wang, Y., & Li, S.-J.
Affiliations: Medical College of Wisconsin (US)
ORCID: Jones, Jennifer L.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-03-27
Volume: 56
Issue: 6
Pages: 737-742
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.56.6.737
OpenAlex: W2101563929
Cited by: 119
References: 42
Citations by year: 2026: 6 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 6
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (5M01-RR00058, M01RR000058)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, glutamate/glutamine, 1H NMR, 0.5T MRI, N-acetylaspartate, myo-inositol, brain metabolites, diagnostic biomarkers, early diagnosis, normal aging, cingulate cortex
MeSH terms: Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Glutamine, Humans, Male, Middle Aged, Magnetic Resonance Spectroscopy, Protons, Glutamic Acid

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Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with 1 H-MRS at 0.5 T

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