Analysis of the MIRIAD Data Shows Sex Differences in Hippocampal Atrophy Progression
Abstract
Background Hippocampus (HC) atrophy is a hallmark of early Alzheimer's disease (AD). Atrophy rates can be measured by high-resolution structural MRI. Longitudinal studies have previously shown sex differences in the progression of functional and cognitive deficits and rates of brain atrophy in early AD dementia. It is important to corroborate these findings on independent datasets. Objective To study temporal rates of HC atrophy over a one-year period in probable AD patients and cognitively normal (CN) subjects by longitudinal MRI scans obtained from the Minimal Interval Resonance Imaging in AD (MIRIAD) database. Methods We used a novel algorithm to compute an index of hippocampal (volumetric) integrity (HI) at baseline and one-year follow-up in 43 mild-moderate probable AD patients and 22 CN subjects in MIRIAD. The diagnostic power of longitudinal HI measurement was assessed using a support vector machines (SVM) classifier. Results The HI was significantly reduced in the AD group (p Conclusion In the MIRIAD patients with probable AD, the HC atrophies at a significantly faster rate in women as compared to men. Female sex is a risk factor for faster descent into AD. The HI measure has potential for AD diagnosis, as a biomarker of AD progression and a therapeutic target in clinical trials.
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Sex is an important factor that contributes to clinical and biological heterogeneity in Alzheimer's disease.
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After diagnosis, women progress faster with more rapid cognitive and functional declines.
“After diagnosis, women also progress faster with more rapid cognitive and functional declines [3–8]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [5]
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- Authors
- Ardekani, B. A., Convit, A., & Bachman, A. H.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Ardekani, Babak A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2016-02-02
- Volume
- 50
- Issue
- 3
- Pages
- 847-857
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2233737392
- Cited by
- 141
- References
- 12
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 22 · 2020: 11 · 2019: 10 · 2018: 15 · 2017: 5 · 2016: 5
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Alzheimer Society
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064087, DK 064087)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- hippocampal atrophy, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Atrophy, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Disease Progression
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