Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans
Open accessAbstract
We set out to determine factors that influence the rate of brain atrophy in 1-year longitudinal magnetic resonance imaging (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive atrophy in 144 subjects with probable Alzheimer's disease (AD) (age: 76.5 +/- 7.4 years), 338 with amnestic mild cognitive impairment (MCI; 76.0 +/- 7.2), and 202 healthy controls (77.0 +/- 5.1), scanned twice, 1 year apart. Statistical maps revealed significant age and sex differences in atrophic rates. Brain atrophic rates were about 1%-1.5% faster in women than men. Atrophy was faster in younger than older subjects, most prominently in mild cognitive impairment, with a 1% increase in the rates of atrophy and 2% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced beta-amyloid and elevated tau levels (n = 363) at baseline, baseline and progressive deterioration in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high-throughput biomarker for tracking disease progression in large imaging studies; sub-analyses focusing on women or younger subjects gave improved sample size requirements for clinical trials.
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The brain atrophy rate is 1-1.5% faster in women with Alzheimer's disease than in men.
“The brain atrophy rate is 1–1.5% faster in women with AD than that in men [6].”
From Sex specific molecular networks and key drivers of Alzheimer’s disease (2023) · cites this paper as [6]
Results §3.1 reports that atrophic rates were about 1–1.5% per year faster in women than men, and says the analyses included an AD group. It does not assign that precise magnitude specifically to participants with AD; the reported sex effect also covers MCI and control participants. (LLM, conf=0.83)
Experimental — accuracy not yet measuredAfter diagnosis, women progress faster with more rapid cognitive and functional declines.
“After diagnosis, women also progress faster with more rapid cognitive and functional declines [3–8]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [8]
The Introduction says women with Alzheimer’s disease may have greater cognitive impairment and functional disability than men. Results §3.1 finds faster brain atrophy in women, but the paper does not establish that women have faster cognitive and functional declines after diagnosis; those are different outcomes from impairment levels and atrophy rates. The indexed passages provide section labels but no page numbers. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSex is an important factor that contributes to clinical and biological heterogeneity in Alzheimer's disease.
“Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD)”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [8]
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“As we noted in Hua et al. (2010b), treatments may slow atrophy to different degrees, which may be denoted by k %, for different k .”
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- Authors
- Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M.
- Affiliations
- University of California, Los Angeles (US)
- Mayo Clinic (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Thompson, Paul M.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 31
- Issue
- 8
- Pages
- 1463-1480
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC2927200
- OpenAlex
- W2103030628
- Cited by
- 234
- References
- 153
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 40 · 2023: 21 · 2022: 20 · 2021: 23 · 2020: 15 · 2019: 12 · 2018: 19 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 3 · 2013: 12 · 2012: 3
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Dana Foundation
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD050735)
- National Institutes of Health (K01 AG030514, P30 AG010129, U54-RR021813)
- National Institute of Biomedical Imaging and Bioengineering (R01 EB007813, R01 EB008281, R01 EB008432)
- National Institute on Aging (R01 AG020098)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- brain atrophy rate, sex differences, age differences, Alzheimer's disease, amnestic mild cognitive impairment, ventriculomegaly, amyloid-beta, tau protein, APOE ε4, disease progression biomarkers
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Sex Characteristics, Disease Progression
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