The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Relative incidence of seizures and myoclonus in Alzheimer’s disease, dementia with lewy bodies, and frontotemporal dementia.
Open accessAbstract
BACKGROUND: Patients with Alzheimer's disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms among other dementia types is unknown. OBJECTIVE: To determine incidence of seizures and myoclonus in the three most common neurodegenerative dementias: AD, dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). METHODS: Our institution's medical records were reviewed for new-onset unprovoked seizures and myoclonus in patients meeting criteria for AD (n = 1,320), DLB (n = 178), and FTD (n = 348). Cumulative probabilities of developing seizures and myoclonus were compared between diagnostic groups, whereas age-stratified incidence rates were determined relative to control populations. RESULTS: The cumulative probability of developing seizures after disease onset was 11.5% overall, highest in AD (13.4%) and DLB (14.7%) and lowest in FTD (3.0%). The cumulative probability of developing myoclonus was 42.1% overall, highest in DLB (58.1%). The seizure incidence rates, relative to control populations, were nearly 10-fold in AD and DLB, and 6-fold in FTD. Relative seizure rates increased with earlier age-at-onset in AD (age <50, 127-fold; 50-69, 21-fold; 70+, 2-fold) and FTD (age <50, 53-fold; 50-69, 9-fold), and relative myoclonus rates increased with earlier age-at-onset in all groups. Seizures began an average of 3.9 years after the onset of cognitive or motor decline, and myoclonus began 5.4 years after onset. CONCLUSIONS: Seizures and myoclonus occur with greater incidence in patients with AD, DLB, and FTD than in the general population, but rates vary with diagnosis, suggesting varied pathomechanisms of network hyperexcitability. Patients often experience these symptoms early in disease, suggesting hyperexcitability could be an important target for interventions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the possibility of seizures and hyperexcitability in primary tauopathies should not be ruled out, as they occur more frequently in these diseases than in the general population (Beagle et al., 2017; Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Beagle et al., 2017
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Seizures are more common in AD and dementia with Lewy bodies than in primary tauopathies, such as frontotemporal dementia and progressive supranuclear palsy (Beagle et al., 2017).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Beagle et al., 2017
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A mechanism by which epileptogenesis gives rise to tau hyperphosphorylation may underlie the high incidence of tauopathy and epilepsy co-pathology that is found in diseases such as AD and dementia with Lewy bodies (Vossel et al., 2016, 2017; Beagle et al., 2017).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Beagle et al., 2017
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., Van Emde Boas, W., Engel, J., French, J., Glauser, T. A., Mathern, G. W., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02522.x · Cited by 4,363
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477087 · Cited by 2,774
Research works printed but not linked: 1
- Rothman, 2008, Modern Epidemiology
Cited by
Sorted by citations
Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401
Biological aging processes underlying cognitive decline and neurodegenerative disease
Gonzales, M. M., Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Kraig, E., & Orr, M. E. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158453 · Cited by 426
Vossel, K. A., Ranasinghe, K. G., Beagle, A. J., La, A. L., Pook, K. A., Castro, M. R., Mizuiri, D., Honma, S. M., Venkateswaran, N., KOESTLER, M. E., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.3310 · Cited by 277
Self-citationJiménez-Baladó, J., & Eich, T. S. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.01.005 · Cited by 194
Bowles, K. R., Silva, M. C., Whitney, K., Bertucci, T., Berlind, J. E., Lai, J. D., Garza, J. C., Boles, N. C., Mahali, S., Strang, K. H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.003 · Cited by 175
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
Sohn, P. D., Huang, C. T.-L., Yan, R., Fan, L., Tracy, T. E., Camargo, C. M., Montgomery, K. M., Arhar, T., Mok, S.-A., Freilich, R., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.008 · Cited by 148
“Excitability of neuronal networks is aberrantly increased in patients with frontotemporal dementia (FTD) (Beagle et al., 2017) and in mouse models with FTD-associated tau mutations (Crimins et al.”
BackgroundA European Academy of Neurology guideline on medical management issues in dementia
Frederiksen, K. S., Cooper, C., Frisoni, G. B., Frölich, L., Georges, J., Kramberger, M. G., Nilsson, C., Passmore, P., Ritter, L. M., Religa, D., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14412 · Cited by 106
Unsupervised excitation: GABAergic dysfunctions in Alzheimer’s disease
Giovannetti, E. A., & Fuhrmann, M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.042 · Cited by 105
Bi-directional association between epilepsy and dementia
Stefanidou, M., Beiser, A., Himali, J. J., Peng, T. J., Devinsky, O., Seshadri, S. S., & Friedman, D. J. (2020) · Neurology · doi:10.1212/wnl.0000000000011077 · Cited by 94
Kamondi, A., Grigg-Damberger, M. M., Löscher, W., Tanila, H., & Horvath, A. A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00932-4 · Cited by 104
Dementia in late-onset epilepsy
Johnson, E. L., Krauss, G. L., Kucharska‐Newton, A., Albert, M., Brandt, J., Walker, K. A., Yaşar, S., Knopman, D. S., Vossel, K. A., & Gottesman, R. F. (2020) · Neurology · doi:10.1212/wnl.0000000000011080 · Cited by 89
Self-citationSingh, B., Covelo, A., Martell-Martinez, H. A., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J. P., Teravskis, P. J., Gallardo, C., Savonenko, A. V., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02032-w · Cited by 85
Epilepsy in neurodegenerative diseases
Neri, S., Mastroianni, G., Gardella, E., Aguglia, U., & Rubboli, G. (2022) · Epileptic Disorders · doi:10.1684/epd.2021.1406 · Cited by 84
Epilepsy and Alzheimer’s Disease: Potential mechanisms for an association
Giorgi, F. S., Saccaro, L. F., Busceti, C. L., Biagioni, F., & Fornai, F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.009 · Cited by 80
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041092 · Cited by 68
Alzheimer Disease and Epilepsy
Fang, Y., Si, X., Wang, J., Wang, Z., Chen, Y., Liu, Y., Yan, Y., Tian, J., Zhang, B., & Pu, J. (2023) · Neurology · doi:10.1212/wnl.0000000000207423 · Cited by 73
Systematic review of coexistent epileptic seizures and Alzheimer's disease: Incidence and prevalence
Xu, Y. H., Lavrencic, L. M., Radford, K. A., Booth, A., Yoshimura, S., Anstey, K. J., Anderson, C. S., & Peters, R. K. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17101 · Cited by 58
Seizure in Alzheimer’s Disease: An Underestimated Phenomenon
Asadollahi, M., Atazadeh, M., & Noroozıan, M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518813551 · Cited by 56
Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach
Upaganlawar, A. B., Wankhede, N. L., Kale, M. B., Umare, M. D., Sehgal, A., Singh, S., Bhatia, S., Al-Harrasi, A., Najda, A., Nurzyńska-Wierdak, R., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112146 · Cited by 53
McDade, E. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001131 · Cited by 56
Increased risk of epilepsy in patients registered in the Swedish Dementia Registry
Zelano, J., Brigo, F., & Ptacek, S. G. (2019) · European Journal of Neurology · doi:10.1111/ene.14043 · Cited by 49
Caviness, J. N. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000750 · Cited by 48
Neurodevelopmental Clues to Neurodegeneration
Schor, N. F., & Bianchi, D. W. (2021) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2021.07.012 · Cited by 49
Epilepsy in Neurodegenerative Dementias: A Clinical, Epidemiological, and EEG Study
Arnaldi, D., Donniaquio, A., Mattioli, P., Massa, F., Grazzini, M., Meli, R., Filippi, L., Grisanti, S. G., Famà, F., Terzaghi, M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191315 · Cited by 39
Mechanisms Involved in Epileptogenesis in Alzheimer’s Disease and Their Therapeutic Implications
Altuna, M., Olmedo‐Saura, G., Carmona‐Iragui, M., & Fortea, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084307 · Cited by 43
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35
“However, the possibility of seizures and hyperexcitability in primary tauopathies should not be ruled out, as they occur more frequently in these diseases than in the general population (Beagle et al., 2017; Sanchez et al., 2018).”
BackgroundInfluentialSelf-citationHorvath, A. A., Csernus, E. A., Lality, S., Kaminski, R. M., & Kamondi, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.557416 · Cited by 32
Dun, C., Zhang, Y., Yin, J., Su, B., Peng, X., & Liu, L. (2022) · Age and Ageing · doi:10.1093/ageing/afac010 · Cited by 34
Ten year cumulative incidence of dementia after late onset epilepsy of unknown etiology
Keret, O., Brauner, R., Benninger, F., & Glik, A. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.01.030 · Cited by 32
Association of Seizure Control with Mortality, Cognition, and Function in People With Dementia
Zawar, I., Quigg, M., Ghosal, S., Punia, V., Calle‐López, Y., Manning, C. A., & Kapur, J. (2024) · Annals of Neurology · doi:10.1002/ana.27125 · Cited by 32
Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
Yang, F., Chen, L., Yu, Y., Xu, T., Chen, L., Yang, W., Wu, Q., & Han, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.940515 · Cited by 31
Peters, S. T., Fahrenkopf, A., Choquette, J. M., Vermilyea, S. C., Lee, M. K., & Vossel, K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00563 · Cited by 29
Self-citationTweedy, C., Kindred, N., Curry, J., Williams, C., Taylor, J., Atkinson, P. J., Randall, F. E., Erskine, D., Morris, C. M., Reeve, A. K., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105226 · Cited by 26
The crosstalk between epilepsy and dementia: A systematic review and meta-analysis
Chen, L., Yang, W., Yang, F., Yu, Y., Xu, T., Wang, D., Zhao, Q., Wu, Q., & Han, Y. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109640 · Cited by 26
The association of seizure control with neuropathology in dementia
Zawar, I., Łuniewski, A., Gundlapalli, R., Manning, C. A., Parikh, P., Kapur, J., & Quigg, M. (2025) · Brain · doi:10.1093/brain/awaf017 · Cited by 29
Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment
Zawar, I., Quigg, M., Johnson, E. L., Ghosal, S., Manning, C. A., & Kapur, J. (2025) · JAMA Neurology · doi:10.1001/jamaneurol.2025.0552 · Cited by 26
Foster, J. B., Lashley, R., Zhao, F., Wang, X., Kung, N., Askwith, C. C., Lin, L., Shultis, M. W., Hodgetts, K. J., & Lin, C. G. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0530-z · Cited by 26
Hautecloque, G., Sellal, F., Bousiges, O., Phillipi, N., Blanc, F., & Cretin, B. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221197 · Cited by 24
Subclinical Epileptiform Activity in Dementia with Lewy Bodies
Musaeus, C. S., Kjær, T. W., Hribljan, M. Č., Andersen, B. B., Høgh, P., Kidmose, P., Fabricius, M. E., Hemmsen, M. C., Rank, M. L., Waldemar, G., et al. (2023) · Movement Disorders · doi:10.1002/mds.29531 · Cited by 25
Pharmacotherapeutic strategies for treating epilepsy in patients with Alzheimer’s disease
Cretin, B. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1496237 · Cited by 25
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda, C. L., Pandit, S., Turrini, S., Reilly, J., Palmisano, A., Sprugnoli, G., Hampel, H. J., Benussi, A., Borroni, B., Press, D. Z., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102509 · Cited by 26
Epilepsy and prion diseases: A narrative review
Mbizvo, G. K., Ziso, B., & Larner, A. J. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107630 · Cited by 24
Vicente, M. C., Addo-Osafo, K., & Vossel, K. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1277613 · Cited by 25
Self-citationThe Kynurenine Pathway, Aryl Hydrocarbon Receptor, and Alzheimer’s Disease
Cortés-Malagón, E. M., Ornelas, A. L., Olvera‐Gómez, I., & Bonilla‐Delgado, J. (2024) · Brain Sciences · doi:10.3390/brainsci14090950 · Cited by 27
Epileptic Mechanisms Shared by Alzheimer’s Disease: Viewed via the Unique Lens of Genetic Epilepsy
Kang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137133 · Cited by 23
Kiss, É., Kins, S., Zöller, Y., Schilling, S., Gorgas, K., Groß, D., Schlicksupp, A., Rosner, R., Kirsch, J., & Kuhse, J. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103624 · Cited by 22
The overlap between epilepsy and Alzheimer’s disease and the consequences for treatment
Powell, G. A., Ziso, B., & Larner, A. J. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1629289 · Cited by 22
Zhao, B. T., Shen, L.-X., Ou, Y., Ma, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101478 · Cited by 19
Seizure prevalence in neurodegenerative diseases—a study of autopsy proven cases
Vöglein, J., Kostova, I., Arzberger, T., Noachtar, S., Dieterich, M., Herms, J. W., Schmitz, P., Ruf, V., Windl, O., Roeber, S., et al. (2021) · European Journal of Neurology · doi:10.1111/ene.15089 · Cited by 18
Seizure occurrence and related mortality in dementia with Lewy bodies
Marawar, R., Wakim, N. I., Albin, R. L., & Dodge, H. H. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107311 · Cited by 18
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia
Shabir, O., Moll, T., Matuszyk, M. M., Eyre, B., Dake, M. D., Berwick, J., & Francis, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111361 · Cited by 17
Moguilner, S., Herzog, R. A., Perl, Y. S., Medel, V., Cruzat, J., Coronel, C., Kringelbach, M. L., Deco, G., Ibáñez, A. M., & Tagliazucchi, E. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01449-0 · Cited by 15
Predictors of New-Onset Epilepsy in People With Younger-Onset Neurocognitive Disorders
Wang, X., Loi, S. M., Foster, E., Chen, Z. Z., Velakoulis, D., & Kwan, P. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.637260 · Cited by 16
NDUFA1 p.Gly32Arg variant in early-onset dementia
Huttula, S., Väyrynen, H., Helisalmi, S., Kytövuori, L., Luukkainen, L., Hiltunen, M., Remes, A. M., & Krüger, J. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.026 · Cited by 15
Palliative care for people with dementia
Timmons, S., & Fox, S. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-824535-4.00013-6 · Cited by 16
Diagnosis and Management of Seizures in Neurodegenerative Diseases
Adan, G., Mitchell, J., Ziso, B., & Larner, A. J. (2021) · Current Treatment Options in Neurology · doi:10.1007/s11940-020-00656-y · Cited by 15
Cope, Z. A., Murai, T., & Rizzo, S. J. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.805063 · Cited by 18
Lu, O., Kouser, T., & Skylar‐Scott, I. A. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1241339 · Cited by 14
Treatment of Seizures in Older Patients with Dementia
Cretin, B. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00826-2 · Cited by 14
Epileptic activity in Alzheimer's disease: emerging insights and therapeutic implications
Vossel, K. A., Johnson, E. L., Cretin, B., & Matsumoto, R. (2026) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00425-9 · Cited by 15
Self-citationMimura, Y., Tobari, Y., Nakahara, K., Nakajima, S., Yoshida, K., Mimura, M., & Noda, Y. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105451 · Cited by 15
Stylianou, M., Zaaimi, B., Thomas, A. J., Taylor, J., & LeBeau, F. E. N. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.579867 · Cited by 13
Kawakatsu, S., Kobayashi, R., Hayashi, H., Morioka, D., Utsunomiya, A., Kabasawa, T., Ohe, R., & Otani, K. (2021) · Neuropathology · doi:10.1111/neup.12765 · Cited by 12
Epileptic variant in the spectrum of Alzheimer's disease – practical implications
Cretin, B. (2024) · Seizure · doi:10.1016/j.seizure.2024.09.015 · Cited by 12
Anton, P. E., Maphis, N. M., Linsenbardt, D. N., & Coleman, L. G. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_10 · Cited by 12
Cognitive Effects of Montelukast: A Pharmaco-EEG Study
Schwimmbeck, F., Staffen, W., Höhn, C., Rossini, F., Renz, N., Lobendanz, M., Reichenpfader, P., Iglseder, B., Aigner, L., Trinka, E., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11050547 · Cited by 12
Court, T., Taipale, H. T., Lavikainen, P., Tiihonen, J., Tanskanen, A. J., Hartikainen, S. A., & Tolppanen, A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180594 · Cited by 12
Tackling seizures in patients with Alzheimer’s disease
Tombini, M., Boscarino, M., & Lazzaro, V. D. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2278487 · Cited by 11
Shmara, A., Gibbs, L., Mahoney, R. P., Hurth, K. M., Goodwill, V., Cuber, A., Im, R., Pizzo, D. P., Brown, J. M., Laukaitis, C. M., et al. (2023) · Neurology Genetics · doi:10.1212/nxg.0000000000200037 · Cited by 11
Giannoccaro, M. P., Verde, F., Morelli, L., Rizzo, G., Ricciardiello, F., & Liguori, R. (2023) · Biomedicines · doi:10.3390/biomedicines11030666 · Cited by 13
Chartampila, E., Elayouby, K. S., Leary, P., LaFrancois, J. J., Alcantara‐Gonzalez, D., Jain, S. S., Gerencer, K., Botterill, J. J., Ginsberg, S. D., & Scharfman, H. E. (2024) · eLife · doi:10.7554/elife.89889.4 · Cited by 10
Käufer, C., Stanojlović, M., Schidlitzki, A., Bonsberger, J., Storch, A., & Richter, F. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x241310723 · Cited by 10
Buss, S. S., Fried, P. J., Macone, J., Zeng, V., Zingg, E., Santarnecchi, E., Pascual‐Leone, Á., & Bartrés‐Faz, D. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1193407 · Cited by 10
A Reappraisal on cortical myoclonus and brief Remarks on myoclonus of different Origins
Canafoglia, L., Meletti, S., Bisulli, F., Alvisi, L., Assenza, G., d’Orsi, G., Dubbioso, R., Ferlazzo, E., Ferri, L., Franceschetti, S., et al. (2024) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2024.10.001 · Cited by 9
Prevalence of Epilepsy in Frontotemporal Dementia and Timing of Dementia Diagnosis
Kilpeläinen, A., Aaltonen, M., Aho, K., Heikkinen, S. V., Kivisild, A., Lehtonen, A., Leppänen, L., Rinnankoski, I., Soppela, H., Tervonen, L., et al. (2025) · JAMA Neurology · doi:10.1001/jamaneurol.2025.1358 · Cited by 9
Musaeus, C. S., Kjær, T. W., Lindberg, U., Vestergaard, M. B., Bo, H., Larsson, W., Press, D. Z., Andersen, B. B., Høgh, P., Kidmose, P., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01432-9 · Cited by 9
Differential Effects of Human P301L Tau Expression in Young versus Aged Mice
Hunsberger, H. C., Setti, S. E., Rudy, C. C., Weitzner, D. S., Pfitzer, J. C., McDonald, K. L., Hong, H., Bhattacharya, S., Suppiramaniam, V. D., & Reed, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111637 · Cited by 10
Seizures and Epilepsy in the Elderly: Diagnostic and Treatment Considerations
Elder, C. J., & Mendiratta, A. (2020) · Current Geriatrics Reports · doi:10.1007/s13670-020-00310-0 · Cited by 9
Hauser, W. A., Lleó, A., & Schmolck, H. (2020) · Neurology · doi:10.1212/wnl.0000000000011084 · Cited by 9
Yabuki, Y., Liu, J., Kawahata, K., Izumi, H., Shinoda, Y., Koga, K., Ueno, S., Shioda, N., & Fukunaga, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155525 · Cited by 9
The overlap between Alzheimer's disease and epilepsy uncovered by transcriptome sequencing
Jiang, X., Lu, H., Liu, W., Wu, Z., Wu, Q., Li, X., Xu, Z., Hui, F., & Zhao, Q. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.169 · Cited by 8
Morioka, T., Inoha, S., Mugita, F., Oketani, H., Shimogawa, T., Mukae, N., Maehara, N., Akiyama, T., Miki, K., Karashima, S., et al. (2024) · Epilepsy & Seizure · doi:10.3805/eands.16.29 · Cited by 7
Itsuno, M., Tanabe, H., Sano, E., Sasaki, T., Oyama, C., Bannai, H., Saito, K., Nakata, K., Endoh‐Yamagami, S., Okano, H., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.12.009 · Cited by 7
Epilepsy and Alzheimer disease: New insights and perspectives
Dupont, S. (2025) · Revue Neurologique · doi:10.1016/j.neurol.2025.03.005 · Cited by 7
Lehmann, L. M., & Barker‐Haliski, M. L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1223472 · Cited by 6
Chartampila, E., Elayouby, K. S., Leary, P., LaFrancois, J. J., Alcantara‐Gonzalez, D., Jain, S. S., Gerencer, K., Botterill, J. J., Ginsberg, S. D., & Scharfman, H. E. (2024) · eLife · doi:10.7554/elife.89889 · Cited by 19
Rissardo, J. P., & Caprara, A. L. F. (2025) · Brain Circulation · doi:10.4103/bc.bc_134_24 · Cited by 7
Pharmacological treatment for older adults with epilepsy and comorbid neurodegenerative disorders
O’Dwyer, R., Foster, E., Leppik, I. E., & Kwan, P. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001143 · Cited by 7
Editorial: Silent Seizures and Memory Loss in Alzheimer's Disease
Vossel, K. A., & Karageorgiou, E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.648650 · Cited by 7
Self-citationMediators of epilepsy risk after traumatic brain injury: A 20‐year U.S. veteran cohort study
Vadlamani, S., Ozmen, M., Gugger, J. J., Cheney, A., Amuan, M. E., Diaz-Arrastia, R. R., Pugh, M. J., & Kennedy, E. (2024) · Epilepsia · doi:10.1111/epi.18248 · Cited by 7
Toral-Ríos, D., Pichardo‐Rojas, P. S., Ruiz-Sánchez, E., Rosas‐Carrasco, Ó., Carvajal-García, R., Gálvez-Coutiño, D. C., Martínez‐Rodríguez, N., Rubio-Chávez, A. D., Alcántara-Flores, M., López-Ramírez, A. M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810228 · Cited by 6
Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer’s disease
Wu, M., Zhang, R., Fu, P., & Mei, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.029 · Cited by 6
Does epilepsy contribute to the clinical phenotype of C9orf72 mutation in fronto-temporal dementia?
Muroni, A., Floris, G., Polizzi, L., Fadda, L., Piga, G., Primicerio, G. C., Rocchi, L., & Defazio, G. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108783 · Cited by 6
A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal ActivityPreprint
Boggess, S. C., Gandhi, V., Tsai, M., Marzette, E., Teyssier, N., Chou, J. Y.-Y., Hu, X., Cramer, A. L., Yadanar, L., Shroff, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582546 · Cited by 6
Point prevalence of epilepsy in dementia: A “real‐world” estimate
Muroni, A., Floris, G., Borghero, G., Ardu, S., Pateri, M. I., Pilotto, S., Pisano, G., & Defazio, G. (2024) · Epileptic Disorders · doi:10.1002/epd2.20199 · Cited by 5
Autoimmune Encephalitis as Treatment-Responsive Cause of Rapidly Progressive Dementia
van Steenhoven, R. W., Bastiaansen, A. E. M., Kerstens, J., Crijnen, Y. S., Brand, T., Brenner, J., Bienfait, T. M., de Vries, J. M., Piura, Y. D., Satyadev, N., et al. (2026) · Neurology · doi:10.1212/wnl.0000000000214933 · Cited by 5
Neurological Emergencies in Geriatric Patients
Borja, M. J., Guarnizo, A. P., Lustrin, E. S., Mehuron, T., Zhu, B., Сапожников, С. А., Zakhari, N., & Torres, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87661-2.00003-8 · Cited by 5
Epilepsy and Neurodegeneration: A Bidirectional Relationship
Szaflarski, J. P. (2021) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759721989668 · Cited by 6
Rocca, F., Kennedy, J., Osman, S., Reisz, Z., King, A. P., Bódi, I., Al‐Sarraj, S., & Troakes, C. (2025) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.70034 · Cited by 4
Al-Musawi, I., Dennis, B. H., Clowry, G. J., & LeBeau, F. E. N. (2024) · Frontiers in Dementia · doi:10.3389/frdem.2024.1404841 · Cited by 5
Metadata
- Authors
- Beagle, A. J., Darwish, S. M., Ranasinghe, K. G., La, A. L., Karageorgiou, E., & Vossel, K. A.
- Affiliations
- University of California, San Francisco (US)
- University of Minnesota (US)
- Corresponding author
- Vossel, Keith A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2017-08-29
- Volume
- 60
- Issue
- 1
- Pages
- 211-223
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC5608587
- OpenAlex
- W2746678792
- Cited by
- 173
- References
- 62
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 27 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 27 · 2019: 10 · 2018: 8
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, San Francisco
- National Institute on Aging (K23AG038357, F32AG050434)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, dementia with Lewy bodies
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Male, Middle Aged, Myoclonus, Psychiatric Status Rating Scales, Retrospective Studies, Seizures, Severity of Illness Index, Incidence, Age Distribution, Lewy Body Disease, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
