Cited by 336Dementia and Cognitive Impairment ResearchEpilepsy research and treatmentAlzheimer's disease research and treatments

Seizures and myoclonus in patients with Alzheimer's disease

Hauser, W. Allen, Morris, Marcia L., Heston, Leonard L., Anderson, V. Elving·1986·Neurology

Abstract

We reviewed 81 patients with dementia and autopsy findings of Alzheimer's disease (AD) to identify patients with seizures or myoclonus after onset of dementia. Eight (10%) had seizures, and eight others (10%) had myoclonus. The incidence of seizures was 10 times more than expected in a reference population. Seizures occurred in any stage of AD, but myoclonus was often a late manifestation. Both seizures and myoclonus, individually or together, are manifestations of AD and may be seen at any time in the course of the illness.

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Crossref · 10.1212/wnl.36.9.1226

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  • Loss of inhibitory neurons would naturally be expected to disrupt excitatory and inhibitory balance; impaired inhibition may therefore increase the susceptibility of patients with AD to epilepsy.

    “Loss of inhibitory neurons would naturally be expected to disrupt excitatory and inhibitory balance; impaired inhibition may therefore increase the susceptibility of patients with AD to epilepsy, a clinical symptom found in more than 10% of patients88.”

    From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [88]

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Authors
Hauser, W. A., Morris, M. L., Heston, L. L., & Anderson, V. E.
Affiliations
University of Minnesota (US)
Venue
Neurology
Published
1986-09
Volume
36
Issue
9
Pages
1226-1226
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2010891279
Cited by
336
References
0
Citations by year
2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 18
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (1-P50-NS16308, P50NS016308)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, seizures, myoclonus, dementia, autopsy findings, seizure incidence, late-stage dementia
MeSH terms
Aged, Alzheimer Disease, Epilepsies, Myoclonic, Humans, Middle Aged, Seizures

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