Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer’s Disease Brains
Abstract
Lipids are considered important factors in the pathogenesis of Alzheimer’s disease (AD). In this study, we realized a comparative analysis of the phospholipid profile and phospholipid composition of the temporal cortex from E280A-familiar AD (FAD), sporadic AD (SAD), and healthy human brains. Findings showed a significant decrease of lysophosphatidylcholine and phosphatidylethanolamine formed by low levels of polyunsaturated fatty acids (20 : 4, 22 : 6) in AD brains. However, phosphatidylethanolamine-ceramide and phosphoglycerol were significantly increased in SAD, conformed by high levels of (18 : 0/18 : 1) and (30/32/36 : 0/1/2), respectively. Together, the findings suggest a deficiency in lysophosphacholine and phosphatidylethanolamine, and alteration in the balance between poly- and unsaturated fatty acids in both types of AD, and a differential pattern of phospholipid profile and fatty acid composition between E280A FAD and SAD human brains.
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Previous studies of our group have identified molecular differences between SAD and FAD in addition to divergences in clinical manifestations.
“Previous studies of our group have identified molecular differences between SAD and FAD [55, 56, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79] in addition to divergences in the clinical manifestations [55, 56].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [72]
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Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13119 · Cited by 11 · see citing works
Self-citation
- Authors
- Villamil-Ortiz, J. G., Barrera-Ocampo, A., Arias-Londoño, J. D., Villegas, A., Lopera, F., & Cardona-Gómez, G. P.
- Affiliations
- Universidad de Antioquia (CO)
- University of Antioquia UdeA
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2017-11-08
- Volume
- 61
- Issue
- 1
- Pages
- 209-219
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2767851428
- Cited by
- 24
- References
- 6
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
- Universidad de Antioquia
- National Center for Research Resources
- Division of Molecular and Cellular Biosciences
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, familial Alzheimer's disease
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alanine, Alzheimer Disease, Analysis of Variance, Fatty Acids, Female, Gene Expression Regulation, Humans, Lysophosphatidylcholines, Male, Middle Aged, Mutation, Phosphatidylethanolamines, Phospholipids, Mass Spectrometry, Temporal Lobe, Glutamic Acid, Presenilin-1
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