Cited by 285Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

Scheff, Stephen W., Price, Douglas A.·2006·Journal of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is a progressive disorder that is characterized by the accumulation of neuropathologic lesions and neurochemical alterations. Ultrastructural investigations in many association regions of the neocortex and the hippocampal dentate gyrus have demonstrated a disease-related decline in numerical synaptic density. This decline in brain connectivity occurs early in the disease process and strongly correlates with the cognitive decline observed in AD. The synapse loss does not appear to be an inevitable consequence of the aging process. This article reviews the ultrastructural studies assessing AD-related synaptic loss and the possible compensatory changes in the synaptic complex that occur as a result of the loss in brain connectivity.

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Registry

Crossref · 10.3233/jad-2006-9s312

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99 of 99 references verified0 citation errors · 0 not checkable

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  • Synapse loss, as occurs in Alzheimer's patients, is intimately associated with cognitive decline.

    “Synapse loss, as occurs in Alzheimer’s patients, is intimately associated with cognitive decline”

    From Human Brain/Cloud Interface (2019) · cites this paper as Scheff and Price, 2006

  • The loss of synapses, as occurs in Alzheimer's patients, is intimately related to cognitive decline.

    “The loss of synapses, as occurs in Alzheimer’s patients, is intimately related to cognitive decline (Dekosky and Scheff, 1990; Terry et al., 1991; Scheff and Price, 2006).”

    From Human Brain/Cloud Interface (2019) · cites this paper as Scheff and Price, 2006

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Authors
Scheff, S. W., & Price, D. A.
Affiliations
University of Kentucky (US)
Corresponding author
Scheff, Stephen W.
Venue
Journal of Alzheimer's Disease
Published
2006-07-27
Volume
9
Issue
s3
Pages
101-115
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1694984064
Cited by
284
References
99
Citations by year
2026: 9 · 2025: 5 · 2024: 22 · 2023: 15 · 2022: 10 · 2021: 14 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 18 · 2014: 15 · 2013: 20 · 2012: 22
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r37ag012138-05, 5r01ag012986-03)
  • National Institute on Aging (P50AG005144, AG-14449, AG-05144, P01AG005119, P01AG014449, AG0 5119, AG12986, AG12138)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, synaptic density
MeSH terms
Age Factors, Aged, Aging, Alzheimer Disease, Cell Count, Cerebral Cortex, Hippocampus, Humans, Nerve Net, Synapses, Ultrasonography

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