Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

Khan, Usman A; Liu, Li; Provenzano, Frank A; Berman, Diego E; Profaci, Caterina P; Sloan, Richard; Mayeux, Richard; Duff, Karen E; Small, Scott A

doi:10.1038/nn.3606

Cited by 561Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMemory and Neural Mechanisms

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

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Khan, Usman A, Liu, Li, Provenzano, Frank A, Berman, Diego E, Profaci, Caterina P, Sloan, Richard, Mayeux, Richard, Duff, Karen E +1 more·2014·Nature Neuroscience

DOI 10.1038/nn.3606PMC PMC4044925

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Abstract

The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects in patients and mouse models to address basic questions about entorhinal cortex pathophysiology. The entorhinal cortex is divided into functionally distinct regions, the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC), and we exploited the high-resolution capabilities of the fMRI variant to ask whether either of them was affected in patients with preclinical Alzheimer's disease. Next, we imaged three mouse models of disease to clarify how tau and APP relate to entorhinal cortex dysfunction and to determine whether the entorhinal cortex can act as a source of dysfunction observed in other cortical areas. We found that the LEC was affected in preclinical disease, that LEC dysfunction could spread to the parietal cortex during preclinical disease and that APP expression potentiated tau toxicity in driving LEC dysfunction, thereby helping to explain regional vulnerability in the disease.

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The hippocampal region is important to short-term memory loss in AD and is the earliest region involved in the progression of the disease.
“the hippocampal region is important to short-term memory loss in AD and is the earliest region involved in the progression of the disease”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [40]
The Results (LEC versus MEC dysfunction; page unavailable) link impaired delayed retention in early Alzheimer’s disease to the lateral entorhinal cortex, and the Discussion links that task to hippocampal-dependent memory. But the paper identifies the lateral entorhinal cortex—not the hippocampus itself—as the primary early site of dysfunction, so it does not support calling the hippocampus the earliest region involved. (LLM, conf=0.87)
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Authors: Khan, U. A., Liu, L., Provenzano, F. A., Berman, D. E., Profaci, C. P., Sloan, R., Mayeux, R., Duff, K. E., & Small, S. A.
Affiliations: SUNY Downstate Health Sciences University (US)
Columbia University (US)
Corresponding author: Duff, Karen E
Small, Scott A
ORCID: Khan, Usman A
Liu, Li
Provenzano, Frank A
Berman, Diego E
Profaci, Caterina P
Sloan, Richard
Mayeux, Richard
Duff, Karen E
Small, Scott A
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-12-22
Volume: 17
Issue: 2
Pages: 304-311
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3606
PMC: PMC4044925
OpenAlex: W1966100017
Cited by: 561
References: 60
Citations by year: 2026: 23 · 2025: 33 · 2024: 38 · 2023: 52 · 2022: 56 · 2021: 48 · 2020: 51 · 2019: 54 · 2018: 59 · 2017: 54 · 2016: 36 · 2015: 31 · 2014: 23 · 2013: 1
FWCI: 21.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Ministerio de Economía y Competitividad
National Institute on Aging (R01AG034618, R01AG037212, P01AG007232, AG 07232, AG025161, R01AG025161, P50AG008702, AG037212, AG034618)
National Heart, Lung, and Blood Institute (R01HL094423, HL094423)
National Institute of Neurological Disorders and Stroke (NS074874, R01NS074874)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007430)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: preclinical Alzheimer's disease, lateral entorhinal cortex, medial entorhinal cortex, amyloid precursor protein, tau protein, parietal cortex, regional vulnerability, mouse models of Alzheimer's disease
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Animals, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Oxygen, Cortical Spreading Depression, Gene Expression, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Disease Progression, Entorhinal Cortex, Mice

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Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

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