DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer’s Disease
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Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer’s disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes. Of these, 17 were shared with DMPs identified using clinical LOAD markers analyzed independently as continuous variables comprising Rey Auditory Verbal Learning Test scores, cerebrospinal fluid total tau (t-tau) and phosphorylated tau 181 (p-tau 181 ) levels, and t-tau/Aβ1–42 (Aβ 42 ), p-tau 181 /Aβ 42 , and Aβ 42 /Aβ1–40 (Aβ 40 ) ratios. In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were hypomethylated in ZADH2 (Prostaglandin reductase 3) (EC 1.3.1.48).
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DNA methylation alterations can be detected in the blood of AD subjects.
“and can also be detected in the blood of AD subjects [25–31].”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [30]
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The Promise of Epigenetic Editing for Treating Brain Disorders
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DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients
Mohanraj, L., Wolf, H., Silvey, S. G., Liu, J., Toor, A. A., & Swift‐Scanlan, T. (2022) · Biological Research For Nursing · doi:10.1177/10998004221135628 · Cited by 5 · see citing works
Multi-Task Encoder Using Peripheral Blood DNA Methylation Data for Alzheimer’s Disease Prediction
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Molecular etiopathogenesis of neurodegenerative diseases
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Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patientsPreprint
Jąkalski, M., Rychlicka-Buniowska, E., Davies, H., Sarkisyan, D., Siedlar, M., Baran, J., Węglarczyk, K., Jaszczyński, J., Ryś, J., Gedraitis, V., et al. (2023) · medRxiv · doi:10.1101/2023.02.07.23285520 · Cited by 2 · see citing works
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Epigenetics and cognitive disorders
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Hackenhaar, F. S., Josefsson, M., Adolfsson, A. N., Landfors, M., Kauppi, K., Porter, T., Milicic, L., Laws, S. M., Hultdin, M., Adolfsson, R., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2276882/v3
Hackenhaar, F. S., Josefsson, M., Adolfsson, A. N., Landfors, M., Kauppi, K., Porter, T., Milicic, L., Laws, S. M., Hultdin, M., Adolfsson, R., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2276882/v4
Additional file 2 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease
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Deciphering the Interplay: DNA Methylation Dynamics in Aging and Neurodegenerative Diseases
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Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670089
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670062
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670083
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670065
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670059
Additional file 1 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease
C. Silva, T., Zhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Varma, A., Chen, X. S., Martin, E. R., & Wang, L. (2022) · Figshare · doi:10.6084/m9.figshare.21129953
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Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670056
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670086
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670092
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670053
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670044
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670050
Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. E., & Erhardt, A. (2022) · Figshare · doi:10.6084/m9.figshare.19670071
Additional file 2 of Blood DNA methylation and COVID-19 outcomes
Balnis, J., Madrid, A., Hogan, K. J., Drake, L. A., Chieng, H., Tiwari, A., Vincent, C. E., Chopra, A., Vincent, P. A., Robek, M. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14677030
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Blood DNA Methylation Predicts Long-Term Risk of Dementia in Prospective CohortsPreprint
Maihofer, A. X., Mackey, C. E., Robertson, J. A., Marioni, R. E., Nguyen, S., McEvoy, L. K., LaCroix, A. Z., Espeland, M. A., Rapp, S. R., Resnick, S. M., et al. (2026) · medRxiv · doi:10.64898/2026.07.08.26357554
- Authors
- Madrid, A., Hogan, K. J., Papale, L. A., Clark, L. R., Asthana, S., Johnson, S. C., & Alisch, R. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Hogan, Kirk J.
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2018-10-22
- Volume
- 66
- Issue
- 3
- Pages
- 927-934
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC6478383
- OpenAlex
- W2897442393
- Cited by
- 77
- References
- 52
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 35 · 2021: 9 · 2020: 4 · 2019: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (RF1AG027161, P50AG033514, R01AG027161)
- National Institute of Mental Health (F31MH113351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- DNA hypomethylation, late-onset Alzheimer's disease
- MeSH terms
- Memory and Learning Tests, Aged, Aged, 80 and over, Alzheimer Disease, Antigens, Surface, Galactosyltransferases, Humans, Peptide Fragments, Phosphorylation, Trail Making Test, Amyloid beta-Peptides, tau Proteins, DNA Methylation, Cognitive Dysfunction
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