Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research
Open accessAbstract
Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry concerns the extent to which epigenetic signatures measured in more accessible tissues such as blood can serve as a surrogate marker for the brain. Here, we aimed (1) to investigate the blood-brain correspondence of DNA methylation using a within-subject design and (2) to identify changes in DNA methylation of brain-related biological pathways in schizophrenia.We obtained paired blood and temporal lobe biopsy samples simultaneously from 12 epilepsy patients during neurosurgical treatment. Using the Infinium 450K methylation array we calculated similarity of blood and brain DNA methylation for each individual separately. We applied our findings by performing gene set enrichment analyses (GSEA) of peripheral blood DNA methylation data (Infinium 27K) of 111 schizophrenia patients and 122 healthy controls and included only Cytosine-phosphate-Guanine (CpG) sites that were significantly correlated across tissues.Only 7.9% of CpG sites showed a statistically significant, large correlation between blood and brain tissue, a proportion that although small was significantly greater than predicted by chance. GSEA analysis of schizophrenia data revealed altered methylation profiles in pathways related to precursor metabolites and signaling peptides.Our findings indicate that most DNA methylation markers in peripheral blood do not reliably predict brain DNA methylation status. However, a subset of peripheral data may proxy methylation status of brain tissue. Restricting the analysis to these markers can identify meaningful epigenetic differences in schizophrenia and potentially other brain disorders.
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Most DNA methylation markers detected in peripheral tissues cannot accurately predict the DNA methylation status of the brain.
“several studies have reported that most DNA methylation markers detected in the peripheral tissues cannot accurately predict the DNA methylation status of the brain.87”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [87]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263 · see citing works
Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · see citing works
Scale for the Assessment of Negative Symptoms
Andreasen, N. C. (1982) · PsycTESTS Dataset · doi:10.1037/t12696-000 · Cited by 1,878 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Assessing Depression in Schizophrenia: The Calgary Depression Scale
Addington, D. E., Addington, J., & Maticka‐Tyndale, E. (1993) · The British Journal of Psychiatry · doi:10.1192/s0007125000292581 · Cited by 1,177 · see citing works
A data-driven approach to preprocessing Illumina 450K methylation array data
Pidsley, R., Y Wong, C. C., Volta, M., Lunnon, K., Mill, J., & Schalkwyk, L. C. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-293 · Cited by 1,143 · see citing works
Andreasen, N. C., Pressler, M., Nopoulos, P., Miller, D. D., & Ho, B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.040 · Cited by 944 · see citing works
Chen, Y.-A., Lemire, M., Choufani, S., Butcher, D., Grafodatskaya, D., Zanke, B., Gallinger, S., Hudson, T. J., & Weksberg, R. (2013) · Epigenetics · doi:10.4161/epi.23470 · Cited by 908 · see citing works
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905 · see citing works
Ho, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Aging effects on DNA methylation modules in human brain and blood tissue
Horvath, S., Zhang, Y., Langfelder, P., Kahn, R., Boks, M., van Eijk, K., van den Berg, L. H., & Ophoff, R. (2012) · Genome Biology · doi:10.1186/gb-2012-13-10-r97 · Cited by 635 · see citing works
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works
DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing
Brenet, F. A., Moh, M., Funk, P., Feierstein, E., Viale, A. J., Socci, N. D., & Scandura, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014524 · Cited by 627 · see citing works
Reelin promoter hypermethylation in schizophrenia
Grayson, D. R., Jia, X., Chen, Y., Sharma, R. P., Mitchell, C. P., Guidotti, A., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503736102 · Cited by 553 · see citing works
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Abdolmaleky, H. M., Cheng, K.-H., Faraone, S. V., Wilcox, M., Glatt, S. J., Gao, F., Smith, C. L., Shafa, R., Aeali, B., Carnevale, J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl253 · Cited by 462 · see citing works
Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works
Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues
Hon, G. C., Rajagopal, N., Shen, Y., McCleary, D. F., Yue, F., Dang, M. D., & Ren, B. (2013) · Nature Genetics · doi:10.1038/ng.2746 · Cited by 457 · see citing works
DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Lokk, K., Modhukur, V., Rajashekar, B., Märtens, K., Mägi, R., Kolde, R., Koltšina, M., Nilsson, T. K., Vilo, J., Salumets, A., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-4-r54 · Cited by 444 · see citing works
DNA methylation of BDNF as a biomarker of early-life adversity
Kundakovic, M., Gudsnuk, K., Herbstman, J. B., Tang, D., Perera, F. P., & Champagne, F. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408355111 · Cited by 426 · see citing works
Modulation of social memory in male rats by neurohypophyseal peptides
Dantzer, R., Bluthe, R. M., Koob, G. F., & Le Moal, M. (1987) · Psychopharmacology · doi:10.1007/bf00518192 · Cited by 423 · see citing works
Abdolmaleky, H. M., Cheng, K., Russo, A. L., Smith, C. L., Faraone, S. V., Wilcox, M., Shafa, R., Glatt, S. J., Nguyen, G. H., Ponte, J. F., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30140 · Cited by 390 · see citing works
Ammon's Horn Sclerosis: A Maldevelopmental Disorder Associated with Temporal Lobe Epilepsy
Blümcke, I., Thom, M., & Wiestler, O. D. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00436.x · Cited by 375 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
DNA Methylation Signatures within the Human Brain
Ladd‐Acosta, C., Pevsner, J., Sabunciyan, S., Yolken, R. H., Webster, M. J., Dinkins, T., Callinan, P. A., Fan, J., Potash, J. B., & Feinberg, A. P. (2007) · The American Journal of Human Genetics · doi:10.1086/524110 · Cited by 277 · see citing works
Aberg, K. A., McClay, J. L., Nerella, S., Clark, S., Kumar, G., Chen, W., Khachane, A. N., Xie, L., Hudson, A., Gao, G., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3730 · Cited by 248 · see citing works
Genetics of psychosis; insights from views across the genome
O’Donovan, M. C., Craddock, N. J., & Owen, M. J. (2009) · Human Genetics · doi:10.1007/s00439-009-0703-0 · Cited by 213 · see citing works
Melas, P. A., Rogdaki, M., Ösby, U., Schalling, M., Lavebratt, C., & Ekström, T. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-202069 · Cited by 186 · see citing works
Kaminsky, Z. A., Tochigi, M., Jia, P., Pal, M., Mill, J. S., Kwan, A., Ioshikhes, I. P., Vincent, J. B., Kennedy, J. L., Strauss, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.64 · Cited by 132 · see citing works
Centrally injected arginine vasopressin (AVP) facilitates social memory in rats
Moal, M. L., Dantzer, R., Michaud, B., & Koob, G. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90527-1 · Cited by 131 · see citing works
DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients
Ikegame, T., Bundo, M., Sunaga, F., Asai, T., Nishimura, F., Yoshikawa, A., Kawamura, Y., Hibino, H., Tochigi, M., Kakiuchi, C., et al. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.08.004 · Cited by 129 · see citing works
CpG island methylation pattern in different human tissues and its correlation with gene expression
Fan, S., & Zhang, X. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.023 · Cited by 125 · see citing works
Pidsley, R., & Mill, J. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.029 · Cited by 115 · see citing works
Ewald, E. R., Wand, G. S., Seifuddin, F., Yang, X., Tamashiro, K. L., Potash, J. B., Zandi, P., & Lee, R. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.003 · Cited by 105 · see citing works
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Nishioka, M., Bundo, M., Kasai, K., & Iwamoto, K. (2012) · Genome Medicine · doi:10.1186/gm397 · Cited by 90 · see citing works
Ehrlich, S., Morrow, E. M., Roffman, J. L., Wallace, S. R., Naylor, M., Bockholt, H. J., Lundquist, A. P., Yendiki, A., Ho, B., White, T. J. H., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.046 · Cited by 78 · see citing works
Self-citationRubin, L. H., Carter, C. S., Bishop, J. R., Pournajafi‐Nazarloo, H., Harris, M. S. H., Hill, S. K., Reilly, J. L., & Sweeney, J. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.019 · Cited by 65 · see citing works
Theory of mind and its relevance in schizophrenia
Biedermann, F., Frajo-Apor, B., & Hofer, A. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503624 · Cited by 65 · see citing works
Male-Specific Association between Dopamine Receptor D4 Gene Methylation and Schizophrenia
Cheng, J., Wang, Y., Zhou, K., Wang, L., Li, J., Zhuang, Q., Xu, X., Xu, L., Zhang, K., Dai, D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089128 · Cited by 60 · see citing works
Yuferov, V. P., Nielsen, D. A., Levran, O., Randesi, M., Hamon, S., Ho, A., Morgello, S., & Kreek, M. J. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32833eecbc · Cited by 43 · see citing works
Matsuoka, T., Sumiyoshi, T., Tanaka, K., Tsunoda, M., Uehara, T., Itoh, H., & Kurachi, M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.035 · Cited by 40 · see citing works
Ehrlich, S., Walton, E., Roffman, J. L., Weiss, D., Puls, I., Doehler, N., Burghardt, R., Lehmkuhl, U., Hillemacher, T., Muschler, M. A. N., et al. (2012) · The Canadian Journal of Psychiatry · doi:10.1177/070674371205700306 · Cited by 32 · see citing works
Self-citationSütt, S., Altpere, A., Reimets, R., Visnapuu, T., Loomets, M., Raud, S., Salum, T., Mahlapuu, R., Kairane, Č., Zilmer, M., et al. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23508 · Cited by 18 · see citing works
Teltsh, O., Kanyas, K., Karni, O., Levi, A., Korner, M., Ben‐Asher, E., Lancet, D., Hamdan, A., Lerer, B., & Kohn, Y. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30591 · Cited by 18 · see citing works
Demontis, D., Nyegaard, M., Christensen, J., Severinsen, J. E., Hedemand, A., Hansen, T. F., Werge, T. M., Mors, O. N., & Børglum, A. D. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834dc424 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [30]30. First M, Spitzer A, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Nonpatient Edition. New York: New York State Psychiatric Institute; 2002. [Google Scholar]
- [32]32. Andreasen NC. Scale for the Assessment of Positive Symptoms. Iowa City: University Iowa Press; 1984. [Google Scholar]
Cited by
Sorted by citations
Braun, P. R., Han, S., Hing, B., Nagahama, Y., Gaul, L. N., Heinzman, J. T., Grossbach, A. J., Close, L., Dlouhy, B. J., Howard, M. A., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0376-y · Cited by 467 · see citing works
BECon: a tool for interpreting DNA methylation findings from blood in the context of brain
Edgar, R. D., Jones, M. J., Meaney, M. J., Turecki, G., & Kobor, M. S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.171 · Cited by 261 · see citing works
The Science Behind the Academy for Eating Disorders' Nine Truths About Eating Disorders
Schaumberg, K., Welch, E., Breithaupt, L. E., Hübel, C., Baker, J. H., Munn‐Chernoff, M. A., Yılmaz, Z., Ehrlich, S., Mustelin, L., Ghaderi, A., et al. (2017) · European Eating Disorders Review · doi:10.1002/erv.2553 · Cited by 268 · see citing works
Self-citationYuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“87 The latest advancements in array techniques enabled the use of hypothesis-free paradigms to examine the association of DNA methylation changes across the entire genome to study different phenotypes.”
BackgroundMisiak, B., Krefft, M., Bielawski, T., Moustafa, A. A., Sasiadek, M. M., & Frydecka, D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.015 · Cited by 213 · see citing works
Estimation of a significance threshold for epigenome-wide association studies
Saffari, A., Silver, M. J., Zavattari, P., Moi, L., Columbano, A., Meaburn, E. L., & Dudbridge, F. (2018) · Genetic Epidemiology · doi:10.1002/gepi.22086 · Cited by 183 · see citing works
Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168 · see citing works
Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential
Bogdan, R., Salmeron, B. J., Carey, C. E., Arpana Agrawal, A., Calhoun, V. D., Garavan, H., Hariri, A. R., Heinz, A., Hill, M. N., Holmes, A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.030 · Cited by 167 · see citing works
Self-citationHedman, Å. K., Mendelson, M., Marioni, R. E., Gustafsson, S., Joehanes, R., Irvin, M. R., Zhi, D., Sandling, J. K., Yao, C., Liu, C., et al. (2017) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001487 · Cited by 142 · see citing works
Barker, E. D., Walton, E., & Cecil, C. A. M. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12782 · Cited by 134 · see citing works
Self-citationEpigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”
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Younesian, S., Yousefi, A., Momeny, M., Ghaffari, S. H., & Bashash, D. (2022) · Cells · doi:10.3390/cells11213439 · Cited by 128 · see citing works
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Sharma, V., Mehta, V., & Singh, T. G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200128125641 · Cited by 121 · see citing works
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Stoccoro, A., Siciliano, G., Migliore, L., & Coppedè, F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170139 · Cited by 110 · see citing works
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Sawyer, K. M., Zunszain, P. A., Dazzan, P., & Pariante, C. M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0265-4 · Cited by 107 · see citing works
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Qi, S., Yang, X., Zhao, L.-S., Calhoun, V., Perrone-Bizzozero, N., Liu, S., Jiang, R.-T., Jiang, T., Sui, J., & Ma, X.-H. (2018) · Brain : a journal of neurology · doi:10.1093/brain/awx366 · Cited by 102 · see citing works
Self-citationEpigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers
Khavari, B., & Cairns, M. J. (2020) · Cells · doi:10.3390/cells9081837 · Cited by 106 · see citing works
Rubenstein, D. R., Skolnik, H., Berrío, A., Champagne, F. A., Phelps, S. M., & Solomon, J. W. (2015) · Molecular Ecology · doi:10.1111/mec.13483 · Cited by 90 · see citing works
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Stoccoro, A., & Coppedè, F. (2018) · Neurodegenerative Disease Management · doi:10.2217/nmt-2018-0004 · Cited by 90 · see citing works
Meta-analysis of epigenome-wide association studies of cognitive abilities
Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E. J., Li, S., Prada, D., Smith, J. A., Trevisi, L., Tsai, P.-C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-017-0008-y · Cited by 89 · see citing works
Velasco, G., Grillo, G., Touleimat, N., Ferry, L., Ivković, I., Ribiérre, F., Deleuze, J., Chantalat, S., Pïcard, C., & Francastel, C. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy130 · Cited by 82 · see citing works
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Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 87 · see citing works
Sharp, G. C., Arathimos, R., Reese, S. E., Page, C. M., Felix, J. F., Küpers, L. K., Rifas‐Shiman, S. L., Liu, C., The Cohorts for Heart and Aging Research in Genomic Epidemiology plus (CHARGE +) methylation alcohol working group, Burrows, K., et al. (2017) · Epigenomics · doi:10.2217/epi-2017-0095 · Cited by 86 · see citing works
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Liu, C., Jiao, C., Wang, K., & Yuan, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.006 · Cited by 85 · see citing works
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Fries, G. R., Li, Q., McAlpin, B. R., Rein, T., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.010 · Cited by 82 · see citing works
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Maschietto, M., Bastos, L. C., Tahira, A. C., Bastos, E. P., Euclydes, V. L. V., Brentani, A., Fink, G., de Baumont, A., Felipe-Silva, A., Francisco, R. P. V., et al. (2017) · Scientific Reports · doi:10.1038/srep44547 · Cited by 78 · see citing works
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Reppe, S., Lien, T. G., Hsu, Y., Gautvik, V. T., Olstad, O. K., Yu, R., Bakke, H. G., Lyle, R., Kringen, M. K., Glad, I. K., et al. (2017) · Epigenetics · doi:10.1080/15592294.2017.1345832 · Cited by 74 · see citing works
Ewing, E., Kular, L., Fernandes, S. J., Karathanasis, N., Lagani, V., Ruhrmann, S., Tsamardinos, I., Tegner, J. N., Piehl, F., Gómez-Cabrero, D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.042 · Cited by 74 · see citing works
Rubin, L. H., Connelly, J. J., Reilly, J. L., Carter, C. S., Drogos, L. L., Pournajafi‐Nazarloo, H., Ruocco, A. C., Keedy, S., Matthew, I., Tandon, N., et al. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.10.003 · Cited by 72 · see citing works
Chen, J., Zang, Z., Braun, U., Schwarz, K., Harneit, A., Kremer, T., Ma, R., Schweiger, J., Moessnang, C., Geiger, L., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4792 · Cited by 69 · see citing works
Sadiković, B., Aref‐Eshghi, E., Levy, M. A., & Rodenhiser, D. I. (2019) · Epigenomics · doi:10.2217/epi-2018-0192 · Cited by 68 · see citing works
Breastfeeding effects on DNA methylation in the offspring: A systematic literature review
Hartwig, F. P., de Mola, C. L., Davies, N. M., Victora, C. G., & Relton, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173070 · Cited by 69 · see citing works
Associations between indicators of socioeconomic position and DNA methylation: a scoping review
Cerutti, J., Lussier, A., Zhu, Y.-W., Liu, J.-X., & Dunn, E. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01189-0 · Cited by 51 · see citing works
Self-citationSteiger, H., Booij, L., Kahan, E., McGregor, K., Thaler, L., Fletcher, E., Labbe, A., Joober, R., Israël, M., Szyf, M., et al. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170242 · Cited by 64 · see citing works
Methylomic changes during conversion to psychosis
the ICAAR team, Kébir, O., Chaumette, B., Rivollier, F., Miozzo, F., Perreault, L. L., Barhdadi, A., Provost, S., Plaze, M., Bourgin, J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.53 · Cited by 83 · see citing works
Hannon, E. J., Mansell, G., Walker, E., Nabais, M. F., Burrage, J., Kepa, A., Best-Lane, J., Rose, A., Heck, S., Moffitt, T. E., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009443 · Cited by 57 · see citing works
Maternal caregiving and DNA methylation in human infants and children: systematic review
Provenzi, L., Brambilla, M., Scotto di Minico, G., Montirosso, R., & Borgatti, R. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12616 · Cited by 60 · see citing works
Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia
Nabil Fikri, R. M., Norlelawati, A. T., Nour El-Huda, A. R., Hanisah, M. N., Kartini, A., Norsidah, K., & Nor Zamzila, A. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.020 · Cited by 61 · see citing works
Richardson, T., Haycock, P., Zheng, J., Timpson, N., Gaunt, T. R., Smith, G. D., Relton, C., & Hemani, G. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy210 · Cited by 58 · see citing works
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
Magwai, T., Shangase, K. B., Oginga, F. O., Chiliza, B., Mpofana, T., & Xulu, K. R. (2021) · Cells · doi:10.3390/cells10112890 · Cited by 62 · see citing works
Epigenetics, nutrition and mental health. Is there a relationship?
Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1331524 · Cited by 58 · see citing works
Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia
Lin, D., Chen, J., Perrone‐Bizzozero, N. I., Bustillo, J., Du, Y., Calhoun, V. D., & Liu, J. (2018) · Genome Medicine · doi:10.1186/s13073-018-0519-4 · Cited by 58 · see citing works
Self-citationKraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 57 · see citing works
Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults
van Dongen, J., Zilhäo, N. R., Sugden, K., Heijmans, B. T., Hoen, P. A. C. ’., van Meurs, J. B. J., Isaacs, A. J., Jansen, R., Franke, L., Boomsma, D. I., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.016 · Cited by 59 · see citing works
The epigenetics of perinatal stress
Moshe Szyf, A. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/mszyf · Cited by 58 · see citing works
Milaniak, I., Cecil, C. A. M., Barker, E. D., Relton, C. L., Gaunt, T. R., McArdle, W. L., & Jaffee, S. R. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001316 · Cited by 57 · see citing works
Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo‐Roa, T., den Braber, A., Harris, M. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0605-z · Cited by 58 · see citing works
Self-citationZhou, J., Li, M., Wang, X., He, Y., Xia, Y., Sweeney, J. A., Kopp, R. F., Liu, C., & Chen, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.674273 · Cited by 56 · see citing works
Mohandas, N., Bass-Stringer, S., Maksimovic, J., Crompton, K. E., Loke, Y. J., Walstab, J., Reid, S. M., Amor, D. J., Reddihough, D. S., & Craig, J. M. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0457-4 · Cited by 56 · see citing works
Epigenetics of alcohol use disorder—A review of recent advances in DNA methylation profiling
Longley, M. J., Lee, J., Jung, J., & Lohoff, F. W. (2021) · Addiction Biology · doi:10.1111/adb.13006 · Cited by 55 · see citing works
Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia
Teeuw, J., Ori, A. P. S., Brouwer, R. M., de Zwarte, S. M. C., Schnack, H. G., Pol, H. E. H., & Ophoff, R. A. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.04.005 · Cited by 52 · see citing works
Psychotherapy and Genetic Neuroscience: An Emerging Dialog
Jiménez, J. P., Botto, A., Herrera, L., Leighton, C., Rossi, J. L., Quevedo, Y., Silva, J. R., Martínez, F. I., Assar, R., Salazar, L. A., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00257 · Cited by 58 · see citing works
Catale, C., Bussone, S., Iacono, L. L., Viscomi, M. T., Palacios, D., Troisi, A., & Carola, V. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100249 · Cited by 54 · see citing works
Rhie, S., Schreiner, S., Witt, H., Armoskus, C., Lay, F. D., Camarena, A., Spitsyna, V. N., Guo, Y., Berman, B. P., Evgrafov, O., et al. (2018) · Science Advances · doi:10.1126/sciadv.aav8550 · Cited by 50 · see citing works
What Should a Psychiatrist Know About Genetics?
Nürnberger, J. I., Austin, J., Berrettini, W. H., Besterman, A. D., DeLisi, L. E., Grice, D. E., Kennedy, J. L., Moreno‐De‐Luca, D., Potash, J. B., Ross, D. A., et al. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17nr12046 · Cited by 52 · see citing works
DNA methylation patterns associated with oxidative stress in an ageing population
Hedman, Å. K., Zilmer, M., Sundström, J., Lind, L., & Ingelsson, E. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0235-0 · Cited by 50 · see citing works
Neuroimaging genomics in psychiatry—a translational approach
Mufford, M. S., Stein, D. J., Dalvie, S., Groenewold, N. A., Thompson, P. M., & Jahanshad, N. (2017) · Genome Medicine · doi:10.1186/s13073-017-0496-z · Cited by 51 · see citing works
Cell Types in Environmental Epigenetic Studies: Biological and Epidemiological Frameworks
Campbell, K. A., Colacino, J. A., Park, S. K., & Bakulski, K. M. (2020) · Current Environmental Health Reports · doi:10.1007/s40572-020-00287-0 · Cited by 44 · see citing works
Ameer, S. S., Engström, K. S., Hossain, M. B., Concha, G., Vahter, M., & Bröberg, K. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.02.019 · Cited by 49 · see citing works
Caregiver maltreatment causes altered neuronal DNA methylation in female rodents
Blaze, J., & Roth, T. L. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000128 · Cited by 48 · see citing works
Wiers, C. E., Shumay, E., Volkow, N. D., Frieling, H., Kotsiari, A., Lindenmeyer, J., Walter, H., & Bermpohl, F. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.141 · Cited by 48 · see citing works
Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy
Long, H., Feng, L., Kang, J. I., Luo, Z., Xiao, W., Long, L., Yan, X., Zhou, L., & Xiao, B. (2017) · Scientific Reports · doi:10.1038/srep43810 · Cited by 48 · see citing works
DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects
Vaillancourt, K., Ernst, C., Mash, D. C., & Turecki, G. (2017) · Genes · doi:10.3390/genes8050138 · Cited by 48 · see citing works
Bakulski, K. M., Dou, J., Lin, N., London, S. J., & Colacino, J. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-40963-2 · Cited by 48 · see citing works
Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms
Fisher, H. L., Murphy, T. M., Arseneault, L., Caspi, A., Moffitt, T. E., Viana, J. F., Hannon, E. J., Pidsley, R., Burrage, J., Dempster, E. L., et al. (2015) · Epigenetics · doi:10.1080/15592294.2015.1099797 · Cited by 46 · see citing works
Epigenetic insights into multiple sclerosis disease progression
Kular, L., & Jagodic, M. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13045 · Cited by 46 · see citing works
Li, M., Li, Y., Qin, H., Tubbs, J. D., Li, M., Qiao, C., Lin, J., Li, Q., Fan, F., Gou, M., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00968-0 · Cited by 46 · see citing works
Nissen, J. B., Hansen, C. S., Starnawska, A., Mattheisen, M., Børglum, A. D., Buttenschøn, H. N., & Hollegaard, M. V. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00035 · Cited by 46 · see citing works
Kahl, K. G., Georgi, K., Bleich, S., Muschler, M., Hillemacher, T., Hilfiker-Kleinert, D., Schweiger, U., Ding, X., Kotsiari, A., & Frieling, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.002 · Cited by 44 · see citing works
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Jhun, M.-A., Mendelson, M., Wilson, R., Gondalia, R., Joehanes, R., Salfati, E., Zhao, X., Braun, K. V. E., Do, A. N., Hedman, Å. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23899-y · Cited by 44 · see citing works
Cariaga-Martínez, A. E., Sáiz-Ruiz, J., & Alelú‐Paz, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00202 · Cited by 42 · see citing works
Epigenetics of Addiction: Current Knowledge, Challenges, and Future Directions
Cecil, C. A. M., Walton, E., & Viding, E. M. (2016) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2016.77.688 · Cited by 39 · see citing works
Self-citationXiu, J., Li, J., Liu, Z., Wei, H., Zhu, C., Han, R., Liu, Z., Zhu, W., Shen, Y., & Xu, Q. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201967119 · Cited by 40 · see citing works
Schmitt, A., Martins‐de‐Souza, D., Akbarian, S., Cassoli, J. S., Ehrenreich, H., Fischer, A., Fonteh, A. N., Gattaz, W. F., Gawlik, M., Gerlach, M., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224929 · Cited by 41 · see citing works
Suicide epigenetics, a review of recent progress.
Cheung, S., Woo, J., Maes, M., & Zai, C. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.040 · Cited by 35 · see citing works
Ebrahimi, P., Luthman, H., McGuigan, F., & Åkesson, K. (2020) · Epigenetics · doi:10.1080/15592294.2020.1788325 · Cited by 36 · see citing works
Danoff, J. S., Connelly, J. J., Morris, J. P., & Perkeybile, A. M. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100098 · Cited by 36 · see citing works
Methylation of avpr1a in the cortex of wild prairie voles: effects of CpG position and polymorphism
Okhovat, M., Maguire, S. M., & Phelps, S. M. (2017) · Royal Society Open Science · doi:10.1098/rsos.160646 · Cited by 35 · see citing works
Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia
Lin, D., Chen, J., Ehrlich, S., Bustillo, J., Perrone‐Bizzozero, N. I., Walton, E., Clark, V. P., Wang, Y., Jing Sui (Beijing Normal University), my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Du, Y., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx068 · Cited by 34 · see citing works
Self-citationCocaine-induced epigenetic DNA modification in mouse addiction-specific and non-specific tissues
Anier, K., Urb, M., Kipper, K., Herodes, K., Timmusk, T., Zharkovsky, A., & Kalda, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.036 · Cited by 34 · see citing works
Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
Milicic, L., Porter, T., Vacher, M. A., & Laws, S. M. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220109 · Cited by 36 · see citing works
DNA Methylation Analysis of the NR3C1 Gene in Patients with Schizophrenia
Liu, L., Wu, J., Qing, L., Li, J., Yang, H., Ji, A., Yan, M., Hu, L., & Nie, S. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01525-8 · Cited by 33 · see citing works
A machine learning case–control classifier for schizophrenia based on DNA methylation in blood
Gunasekara, C., Hannon, E. J., MacKay, H., Coarfa, C., McQuillin, A., Clair, D. S., Mill, J. S., & Waterland, R. A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01496-3 · Cited by 32 · see citing works
Investigation of correlations between DNA methylation, suicidal behavior and aging
Jeremian, R., Chen, Y., Luca, V. D., Vincent, J. B., Kennedy, J. L., Zai, C. C. H., & Strauss, J. (2017) · Bipolar Disorders · doi:10.1111/bdi.12466 · Cited by 33 · see citing works
Martins, J., Czamara, D., Sauer, S., Rex‐Haffner, M., Dittrich, K., Dörr, P., de Punder, K., Overfeld, J., Knop, A. J. J., Dammering, F., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100336 · Cited by 31 · see citing works
Ciuculete, D. M., Boström, A. E. D., Tuunainen, A., Sohrabi, F., Kular, L., Jagodic, M., Voisin, S. A. C., Mwinyi, J., & Schiöth, H. B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.03.008 · Cited by 29 · see citing works
Boehm, I., Walton, E., Alexander, N., Batury, V.-L., Seidel, M., Geisler, D., King, J. A., Weidner, K., Roessner, V., & Ehrlich, S. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190016 · Cited by 31 · see citing works
Self-citationSokolov, A. V., Manu, D.-M., Nordberg, D. O. T., Boström, A. E. D., Jokinen, J., & Schiöth, H. B. (2023) · Clinical Epigenetics · doi:10.1186/s13148-022-01394-5 · Cited by 29 · see citing works
Reppe, S., Datta, H. K., & Gautvik, K. M. (2017) · Bone · doi:10.1016/j.bone.2017.04.012 · Cited by 29 · see citing works
Caramaschi, D., Neumann, A., Cárdenas, A., Tindula, G. N., Alemany, S., Zillich, L., Pesce, G., Lahti, J. M. T., Havdahl, A., Mulder, R. H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01441-w · Cited by 29 · see citing works
Epigenetic Mechanisms Activated by Childhood Adversity
Krause, B. J., Artigas, R., Sciolla, A., & Hamilton, J. (2020) · Epigenomics · doi:10.2217/epi-2020-0042 · Cited by 29 · see citing works
Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio
Walton, E., Cecil, C. A. M., Suderman, M. J., Liu, J., Turner, J. A., Calhoun, V. D., Ehrlich, S., Relton, C. L., & Barker, E. D. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12740 · Cited by 27 · see citing works
Self-citationRecent Progress in Pharmacogenomics of Antipsychotic Drug Response
Zhang, J., & Malhotra, A. K. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0886-y · Cited by 28 · see citing works
Elevated OPRD1 promoter methylation in Alzheimer’s disease patients
Ji, H., Wang, Y., Liu, G., Chang, L. Y., Chen, Z., Zhou, D., Xu, X., Cui, W., Hong, Q., Jiang, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172335 · Cited by 27 · see citing works
Huang, H., Zhu, Y. L., Eliot, M., Knopik, V. S., McGeary, J. E., Carskadon, M. A., & Hart, A. C. (2017) · SLEEP · doi:10.1093/sleep/zsx063 · Cited by 26 · see citing works
Batury, V.-L., Walton, E., Tam, F. I., Wronski, M., Buchholz, V., Frieling, H., & Ehrlich, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.08.026 · Cited by 27 · see citing works
Self-citationPolyphenolic Compounds Alter Stress‐Induced Patterns of Global DNA Methylation in Brain and Blood
Blaze, J., Wang, J., Ho, L., Mendelev, N., Haghighi, F. G., & Pasinetti, G. M. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700722 · Cited by 25 · see citing works
Ciuculete, D. M., Voisin, S. A. C., Kular, L., Welihinda, N., Jonsson, J., Jagodic, M., Mwinyi, J., & Schiöth, H. B. (2019) · Epigenetics · doi:10.1080/15592294.2019.1700628 · Cited by 26 · see citing works
- Authors
- Walton, E., Hass, J., Liu, J., Roffman, J. L., Bernardoni, F., Roessner, V., Kirsch, M., Schackert, G., Calhoun, V., & Ehrlich, S.
- Affiliations
- King's College London (GB)
- TransDeN Lab (DE)
- Mind Research Network (US)
- Massachusetts General Hospital (US)
- Center for Regenerative Therapies Dresden (DE)
- Technische Universität Dresden (DE)
- Corresponding author
- Ehrlich, Stefan
- ORCID
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-08
- Volume
- 42
- Issue
- 2
- Pages
- 406-414
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC4753587
- OpenAlex
- W2256732880
- Cited by
- 286
- References
- 52
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 14 · 2023: 21 · 2022: 21 · 2021: 39 · 2020: 31 · 2019: 31 · 2018: 36 · 2017: 37 · 2016: 16 · 2015: 5
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Eli Lilly and Company
- National Institutes of Health (5k08mh068540-05)
- National Institute of Mental Health (K08-MH068540)
- National Institute of General Medical Sciences (P20GM103472)
- National Institute of Biomedical Imaging and Bioengineering (R01EB000840, R01EB020407, R01EB005846, R01EB006841)
- National Center for Research Resources (U24RR021992, M01 RR025758-01, P41-RR-14075, U24RR021382, 1U24 RR021382A, UL1RR025758, P41RR014075)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- DNA methylation
- MeSH terms
- Brain, Humans, Schizophrenia, Biomarkers, CpG Islands, DNA Methylation, Epigenesis, Genetic
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