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Cited by 190Dementia and Cognitive Impairment ResearchBlood Pressure and Hypertension StudiesAlzheimer's disease research and treatments

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Midlife Hypertension and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Open access
Lennon, Matthew J., Makkar, Steve R., Crawford, John D., Sachdev, Perminder S.·2019·Journal of Alzheimer’s Disease
DOI 10.3233/jad-190474
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Abstract

Background: Hypertension is an established risk factor for stroke and vascular dementia but recent meta-analyses examining the association between Alzheimer’s disease (AD) and hypertension have found no significant association. These meta-analyses included short term studies starting in late life which may have obscured the real effect of midlife hypertension. Objective: To examine the association of AD with midlife hypertension, by including only studies with a sufficiently long follow up duration. Methods: Relevant studies were found by searches of MEDLINE, EMBASE, and PubMed. Study outcomes were grouped by measures of blood pressure and definition of hypertension (e.g., systolic hypertension > 140 mmHg or > 160 mmHg). We assessed pooled effect estimates using random effects models and heterogeneity of pooled estimates through the I 2 statistic. Results: Literature search found 3,426 publications of which 7 were eligible studies. There was a significant association between systolic hypertension (>160 mm Hg) and AD (HR 1.25, 95CI 1.06 – 1.47, p = 0.0065). Similarly, for systolic hypertension > 140 mm Hg, there was a smaller but still significant association (HR 1.18, 95CI 1.02 – 1.35, p = 0.021). For diastolic hypertension, all four studies found no significant associations between diastolic hypertension and AD, and these data could not be pooled due to heterogeneity in reporting. Conclusions: Our study found that midlife stage 1 and stage 2 systolic hypertension is associated with increased risk of AD by 18 and 25%, respectively, although no association was found for diastolic hypertension. It is likely that assertive control of systolic hypertension starting in midlife is important to preventing AD.

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Crossref · 10.3233/jad-190474

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  • Establishing the connection between vascular dynamics and CSF inflow provides the mechanistic link between vascular pathology and glymphatic stagnation that may explain the increased risk of Alzheimer's disease in patients suffering from cardiovascular diseases.

    “establishing the connection between vascular dynamics and CSF inflow is important because it provides the mechanistic link between vascular pathology and glymphatic stagnation that may explain the increased risk of Alzheimer’s disease in patients suffering from cardiovascular diseases84,85.”

    From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [84]

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Metadata

Authors
Lennon, M. J., Makkar, S. R., Crawford, J. D., & Sachdev, P. S.
Affiliations
UNSW Sydney (AU)
Corresponding author
Lennon, Matthew J.
ORCID
Venue
Journal of Alzheimer’s Disease
Publisher
SAGE Publications
Published
2019-07-29
Volume
71
Issue
1
Pages
307-316
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-190474
OpenAlex
W2965947914
Cited by
190
References
12
Citations by year
2026: 28 · 2025: 37 · 2024: 27 · 2023: 30 · 2022: 25 · 2021: 23 · 2020: 19
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
midlife hypertension, Alzheimer's disease
MeSH terms
Age Factors, Aged, Alzheimer Disease, Humans, Hypertension, Middle Aged, Risk Factors

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