The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat
Open accessAbstract
Diets rich in cholesterol and/or saturated fats have been shown to be detrimental to cognitive performance. Therefore, we fed a cholesterol (2%) and saturated fat (hydrogenated coconut oil, Sat Fat 10%) diet to 16-month old rats for 8 weeks to explore the effects on the working memory performance of middle-aged rats. Lipid profiles revealed elevated plasma triglycerides, total cholesterol, HDL, and LDL for the Sat-Fat group as compared to an iso-caloric control diet (12% soybean oil). Weight gain and food consumption were similar in both groups. Sat-Fat treated rats committed more working memory errors in the water radial arm maze, especially at higher memory loads. Cholesterol, amyloid-beta peptide of 40 (Abeta40) or 42 (Abeta42) residues, and nerve growth factor in cortical regions was unaffected, but hippocampal Map-2 staining was reduced in rats fed a Sat-Fat diet, indicating a loss of dendritic integrity. Map-2 reduction correlated with memory errors. Microglial activation, indicating inflammation and/or gliosis, was also observed in the hippocampus of Sat-Fat fed rats. These data suggest that saturated fat, hydrogenated fat and cholesterol can profoundly impair memory and hippocampal morphology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993
Trans fatty acids and cardiovascular disease
Mozaffarian, D., Katan, M. B., Ascherio, A., Stampfer, M. J., & Willett, W. C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054035 · Cited by 1,752
Cholesterol metabolism in the brain
Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906
Ying, S.-W., Futter, M., Rosenblum, K., Webber, M. J., Hunt, S. P., Bliss, T. V. P., & Bramham, C. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01532.2002 · Cited by 784
Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
Kalmijn, S., van Boxtel, M. P. J., Ocké, M., Verschuren, W. M. M., Kromhout, D., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000103860.75218.a5 · Cited by 524 · cited 1×
“function inmiddle-aged or aged populations [18,33,42, 58].”
Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02280-0 · Cited by 298
Tanaka, S., Ide, M., Shibutani, T., Ohtaki, H., Numazawa, S., Shioda, S., & Yoshida, T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20752 · Cited by 224
Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease
Geddes, J. W., Tekirian, T. L., Soultanian, N. S., Ashford, J. W., Davis, D. G., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00063-8 · Cited by 101
Cited by
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 676
Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091414 · Cited by 324
Kim, D.-G., Krenz, A., Toussaint, L. E., Maurer, K. J., Robinson, S.-A., Yan, A., Torres, L., & Bynoe, M. S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0467-5 · Cited by 330
Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms
Freeman, L. R., Haley-Zitlin, V., Rosenberger, D. S., & Granholm, A.-C. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000092 · Cited by 324
Self-citationSaturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling
Wang, Z., Liu, D., Wang, F., Liu, S., Zhao, S., Ling, E.-A., & Hao, A. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511002868 · Cited by 239
Metadata
- Authors
- Granholm, A.-C., Bimonte-Nelson, H. A., Moore, A. B., Nelson, M. E., Freeman, L. R., & Sambamurti, K.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2008-06-04
- Volume
- 14
- Issue
- 2
- Pages
- 133-145
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2146845170
- Cited by
- 287
- References
- 8
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat. https://app.cochat.ai/papers/10.3233/jad-2008-14202
- The paper
- Granholm, A.-C., Bimonte-Nelson, H. A., Moore, A. B., Nelson, M. E., Freeman, L. R., & Sambamurti, K. (2008). Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-2008-14202
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
