Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
Abstract
The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.
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Treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Treatment with Spirulina-enriched diets reduces pro-inflammatory cytokines in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Treatment with Spirulina-enriched diets ameliorates both spatial and motor learning in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Treatment with Spirulina-enriched diets reduces malondialdehyde (MDA) levels in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to detrimental effects of oxidative stress.
“During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461 · see citing works
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works
Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase
Deng, H., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W.-Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., et al. (1993) · Science · doi:10.1126/science.8351519 · Cited by 1,479 · see citing works
Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461 · see citing works
Antioxidant Capacity of Tea and Common Vegetables
Cao, G., Sofic, E., & Prior, R. L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9602535 · Cited by 1,297 · see citing works
Diet and Health: What Should We Eat?
Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008 · see citing works
Beta‐carotene, carotenoids, and disease prevention in humans
Mayne, S. T. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635686 · Cited by 862 · see citing works
Joseph, J. A., Shukitt‐Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 432 · see citing works
Self-citationAutomated assay of oxygen radical absorbance capacity with the COBAS FARA II
Cao, G., Verdon, C. P., Wu, A. H., Wang, H., & Prior, R. L. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.12.1738 · Cited by 386 · see citing works
Aspects of Free Radical Reactions in Biological Systems: Aging
Leibovitz, B. E., & Siegel, B. V. (1980) · Journal of Gerontology · doi:10.1093/geronj/35.1.45 · Cited by 305 · see citing works
Micronutrients and cancer risk
Willett, W. (1994) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.1162s · Cited by 143 · see citing works
Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function
Bickford, P. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90279-v · Cited by 108 · see citing works
Self-citationCerebellar norepinephrine depletion and impaired acquisition of specific locomotor tasks in rats
Watson, M., & McElligott, J. G. (1984) · Brain Research · doi:10.1016/0006-8993(84)90518-3 · Cited by 102 · see citing works
Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats
Bickford, P. C., Heron, C., Young, D. A., Gerhardt, G. A., & de la Garza, R. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90075-9 · Cited by 87 · see citing works
Self-citationFreedman, R., Hoffer, B. J., Puro, D. G., & Woodward, D. J. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb10391.x · Cited by 81 · see citing works
Purkinje cell number related to rate of classical conditioning
Woodruff‐Pak, D. S., Cronholm, J., & Sheffield, J. B. (1990) · Neuroreport · doi:10.1097/00001756-199010000-00020 · Cited by 66 · see citing works
Spatial Learning and Memory Deficits Induced by Dopamine Administration with Decreased Glutathione
Shukitt‐Hale, B., Erat, S., & Joseph, J. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00399-7 · Cited by 46 · see citing works
Self-citationOn nonlinear random effects models for repeated measurements
Hirst, K., Zerbe, G. O., Boyle, D. W., & Wilkening, R. B. (1991) · Communications in Statistics - Simulation and Computation · doi:10.1080/03610919108812966 · Cited by 42 · see citing works
6-OHDA induced effects upon the acquisition and performance of specific locomotor tasks in rats
Watson, M., & McElligott, J. G. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(83)80016-1 · Cited by 38 · see citing works
Acquisition of a runway motor learning task is impaired by a beta adrenergic antagonist in F344 rats
Heron, C., Gould, T. J., & Bickford, P. C. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00252-9 · Cited by 31 · see citing works
Self-citationAging and Motor Learning: A Possible Role for Norepinephrine in Cerebellar Plasticity
Bickford, P. C. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.1.35 · Cited by 31 · see citing works
Self-citationDiet and coronary heart disease--a review.
Hughes, K. (1995) · PubMed · Cited by 20 · see citing works
Gould, T. J. (1998) · PubMed · Cited by 16 · see citing works
Self-citationGould, T. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01305-x · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
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The Psychology of Learning and Motivation
Ross, B. H. (2012) · Cited by 2,631 · see citing works
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Berry anthocyanins as novel antioxidants in human health and disease prevention
Zafra‐Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700002 · Cited by 885 · see citing works
Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711 · see citing works
Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works
Potential Impact of Strawberries on Human Health: A Review of the Science
Hannum, S. M. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490263756 · Cited by 488 · see citing works
Lipoic acid – biological activity and therapeutic potential
Gorąca, A., Huk-Kolega, H., Piechota-Polańczyk, A., Kleniewska, P., Ciejka, E., & Skibska, B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70600-4 · Cited by 466 · see citing works
Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., Butterfield, D. A., & Morley, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01580.x · Cited by 459 · see citing works
Singh, M., Arseneault, M., Sanderson, J. T., Murthy, V., & Ramassamy, C. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0735073 · Cited by 438 · see citing works
Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 434 · see citing works
Self-citationSchroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373 · see citing works
A Review of Pterostilbene Antioxidant Activity and Disease Modification
McCormack, D., & McFadden, D. W. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/575482 · Cited by 340 · see citing works
Memory enhancing activity of Glycyrrhiza glabra in mice
Dhingra, D., Parle, M., & Kulkarni, S. K. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.01.016 · Cited by 307 · see citing works
Pappas, E. L., & Schaich, K. M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802145377 · Cited by 301 · see citing works
Granholm, A., Bimonte‐Nelson, H. A., Moore, A., Nelson, M. E., Freeman, L. R., & Sambamurti, K. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14202 · Cited by 287 · see citing works
Potential Health Benefits of Berries
Beattie, J., Crozier, A., & Duthie, G. G. (2005) · Current Nutrition & Food Science · doi:10.2174/1573401052953294 · Cited by 279 · see citing works
Papandreou, M. A., Dimakopoulou, A. G., Linardaki, Z. I., Cordopatis, P. A., Klimis‐Zacas, D. J., Margarity, M., & Lamari, F. N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.013 · Cited by 244 · see citing works
Patterned Purkinje cell death in the cerebellum
Sarna, J. R., & Hawkes, R. B. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00114-x · Cited by 242 · see citing works
Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage
Wang, Y., Chang, C.-F., Chou, J., Chen, H.-L., Deng, X., Harvey, B. K., Cadet, J. L., & Bickford, P. C. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.12.014 · Cited by 223 · see citing works
Berry Fruit Supplementation and the Aging Brain
Shukitt‐Hale, B., Lau, F. C., & Joseph, J. A. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072505f · Cited by 218 · see citing works
Self-citationGoyarzu, P., Malin, D. H., Lau, F. C., Taglialatela, G., Moon, W. D., Jennings, R., Moy, E., Moy, D. M., Lippold, S., Shukitt‐Hale, B., et al. (2004) · Nutritional Neuroscience · doi:10.1080/10284150410001710410 · Cited by 213 · see citing works
Self-citationBlalock, E. M., Buechel, H. M., Popovic, J., Geddes, J. W., & Landfield, P. W. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.06.007 · Cited by 211 · see citing works
Dietary Flavonoids as Potential Neuroprotectants
Youdim, K. A., Spencer, J. P. E., Schroeter, H., & Rice-Evans, C. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.052 · Cited by 210 · see citing works
Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H. L., Muggenburg, B. A., Siwak, C. T., Tapp, D., & Cotman, C. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.014 · Cited by 208 · see citing works
Opii, W. O., Joshi, G., Head, E., Milgram, N. W., Muggenburg, B. A., Klein, J. B., Pierce, W. M., Cotman, C. W., & Butterfield, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.012 · Cited by 202 · see citing works
Effects of Concord grape juice on cognitive and motor deficits in aging
Shukitt‐Hale, B., Carey, A. N., Simon, L., Mark, D. A., & Joseph, J. A. (2006) · Nutrition · doi:10.1016/j.nut.2005.07.016 · Cited by 197 · see citing works
Self-citationAmyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain
Smith, M. A., Casadesús, G., Joseph, J. A., & Perry, G. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01021-3 · Cited by 189 · see citing works
Self-citationCotman, C. W., & Head, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15413 · Cited by 188 · see citing works
Shukitt‐Hale, B., Carey, A. N., Jenkins, D. G., Rabin, B. M., & Joseph, J. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.031 · Cited by 173 · see citing works
Self-citationCrews, W. D., Harrison, D. W., & Wright, J. W. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.872 · Cited by 169 · see citing works
Millin, P. M., & Rickert, G. T. (2018) · Antioxidants · doi:10.3390/antiox8010001 · Cited by 169 · see citing works
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Essa, M. M., Subash, S., Al‐Adawi, S., Memon, M. A., Manivasagam, T., & Akbar, M. D. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.139483 · Cited by 172 · see citing works
Effects of blackberries on motor and cognitive function in aged rats
Shukitt‐Hale, B., Cheng, V., & Joseph, J. A. (2009) · Nutritional Neuroscience · doi:10.1179/147683009x423292 · Cited by 166 · see citing works
Self-citationAscorbic Acid: a Promising Memory-Enhancer in Mice
Parle, M., & Dhingra, D. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.129 · Cited by 153 · see citing works
Hosseini, M., Mohammadpour, T., Karami, R., Rajaei, Z., Sadeghnia, H. R., & Soukhtanloo, M. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-014-1742-5 · Cited by 148 · see citing works
Milgram, N. W., Head, E., Muggenburg, B. A., Holowachuk, D., Murphey, H. L., Estrada, J., Ikeda-Douglas, C. J., Zicker, S. C., & Cotman, C. W. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00039-8 · Cited by 145 · see citing works
Gemma, C., Mesches, M. H., Sepesi, B., Choo, K., Holmes, D. B., & Bickford, P. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06114.2002 · Cited by 143 · see citing works
Self-citationMilgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H. L., Muggenberg, B. A., Siwak, C. T., Tapp, P. D., Lowry, S. R., & Cotman, C. W. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.007 · Cited by 143 · see citing works
Shukitt‐Hale, B., Lau, F. C., Carey, A. N., Galli, R. L., Spangler, E. L., Ingram, D. K., & Joseph, J. A. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301487 · Cited by 143 · see citing works
Self-citationAntioxidants: an integrative approach
Lachance, P. A., Nakat, Z., & Jeong, W.-S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00636-0 · Cited by 140 · see citing works
Kosuru, R., Rai, U., Prakash, S., Singh, A., & Singh, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.07.046 · Cited by 137 · see citing works
Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells
Tarozzi, A., Morroni, F., Hrelia, S., Angeloni, C., Marchesi, A., Cantelli‐Forti, G., & Hrelia, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.017 · Cited by 135 · see citing works
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic
Castellani, R. J., Lee, H., Zhu, X., Nunomura, A., Perry, G. L., & Smith, M. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0071-y · Cited by 133 · see citing works
Tavares, L., Figueira, I., Macedo, D., McDougall, G. J., Leitão, M. C., Vieira, H. L. A., Stewart, D., Alves, P. M., Ferreira, R. B., & dos Santos, C. N. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.10.025 · Cited by 130 · see citing works
Sweeney, M. I., Kalt-Torres, W., MacKinnon, S. L., Ashby, J., & Gottschall‐Pass, K. T. (2002) · Nutritional Neuroscience · doi:10.1080/1028415021000055970 · Cited by 129 · see citing works
Battery of behavioral tests in mice that models age-associated changes in human motor function
Justice, J. N., Carter, C. S., Beck, H. J., Gioscia‐Ryan, R. A., McQueen, M. B., Enoka, R. M., & Seals, D. R. (2013) · AGE · doi:10.1007/s11357-013-9589-9 · Cited by 125 · see citing works
Duffy, K. B., Spangler, E. L., Devan, B. D., Guo, Z., Bowker, J. L., Janas, A. M., Hagepanos, A., Minor, R. K., de Cabo, R., Mouton, P. R., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.002 · Cited by 124 · see citing works
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Mani, V., & Parle, M. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.01.016 · Cited by 115 · see citing works
Kolosova, N. G., Shcheglova, T. V., Sergeeva, S. V., & Лоскутова, Л. В. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.022 · Cited by 115 · see citing works
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Self-citationStrömberg, I., Gemma, C., Vila, J., & Bickford, P. C. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.013 · Cited by 110 · see citing works
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Siqueira, I. R., Fochesatto, C., de Andrade, A., Santos, M., Hagen, M. E. K., Belló‐Klein, A., & Netto, C. A. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.03.001 · Cited by 110 · see citing works
Balu, M., Sangeetha, P., Murali, G., & Panneerselvam, C. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.06.001 · Cited by 106 · see citing works
Blalock, E. M., Chen, K.-C., Stromberg, A. J., Norris, C. M., Kadish, I., Kraner, S. D., Porter, N. M., & Landfield, P. W. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.006 · Cited by 102 · see citing works
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Elks, C. M., Reed, S. D., Mariappan, N., Shukitt‐Hale, B., Joseph, J. A., Ingram, D. K., & Francis, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024028 · Cited by 97 · see citing works
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Wyse, Â. T. D. S., & Netto, C. A. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9246-x · Cited by 92 · see citing works
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Lau, F. C., Shukitt‐Hale, B., & Joseph, J. A. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_14 · Cited by 94 · see citing works
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Mani, V., & Parle, M. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.01.007 · Cited by 93 · see citing works
Spirulina attenuates cyclosporine‐induced nephrotoxicity in rats
Khan, M., Shobha, J. C., Mohan, I. K., Naidu, M. U. R., Prayag, A., & Kutala, V. K. (2006) · Journal of Applied Toxicology · doi:10.1002/jat.1159 · Cited by 93 · see citing works
Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats
Mesches, M. H., Gemma, C., Veng, L., Allgeier, C. A., Young, D. A., Browning, M. D., & Bickford, P. C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00116-7 · Cited by 91 · see citing works
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Vila, J., Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2007) · Frontiers in neuroscience · doi:10.1201/9781420005523.ch15 · Cited by 88 · see citing works
Self-citationMicroarray Analysis in Alzheimer's Disease and Normal Aging
Ricciarelli, R., d’Abramo, C., Massone, S., Marinari, U. M., Pronzato, M. A., & Tabaton, M. (2004) · IUBMB Life · doi:10.1080/15216540412331286002 · Cited by 88 · see citing works
Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk
Agarwal, P., Holland, T. M., Wang, Y., Bennett, D. A., & Morris, M. C. (2019) · Nutrients · doi:10.3390/nu11123060 · Cited by 86 · see citing works
Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. A., Cotman, C. W., & Sullivan, P. G. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.014 · Cited by 84 · see citing works
Banji, D., Banji, O. J. F., Pratusha, N. G., & Annamalai, A. R. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.076 · Cited by 83 · see citing works
Rebrin, I., Zicker, S., Wedekind, K. J., Paetau-Robinson, I., Packer, L., & Sohal, R. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.008 · Cited by 82 · see citing works
Lee, M., Lin, R., Shen, L.-Y., Yang, L., Yen, K., & Hou, W. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010622j · Cited by 82 · see citing works
Pitozzi, V., Jacomelli, M., Catelan, D., Servili, M., Taticchi, A., Biggeri, A., Dolara, P., & Giovannelli, L. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1346 · Cited by 76 · see citing works
Kaufmann, J. A., Bickford, P. C., & Taglialatela, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00118.x · Cited by 76 · see citing works
Self-citationdos Reis, E. A., Zugno, A. I., Franzon, R. C., Tagliari, B., Matté, C., Lamers, M. L., Netto, C. A., & Wyse, Â. T. D. S. (2002) · Metabolic Brain Disease · doi:10.1023/a:1019982223034 · Cited by 73 · see citing works
Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task
STRECK, E. L., Bavaresco, C. S., Netto, C. A., & Wyse, Â. T. D. S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.013 · Cited by 71 · see citing works
Antiamnesic Effects of <i>Desmodium gangeticum</i> in Mice
JOSHI, H., & PARLE, M. (2006) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.126.795 · Cited by 70 · see citing works
Mohammadi, H. S., Goudarzi, I., Lashkarbolouki, T., Abrari, K., & Salmani, M. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.015 · Cited by 70 · see citing works
Antioxidant protection and neurodegenerative disease: The role of amyloid-β and tau
Castellani, R. J., Lee, H., Perry, G. L., & Smith, M. A. (2006) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750602100213 · Cited by 70 · see citing works
Dunlap, K. L., Reynolds, A. J., & Duffy, L. K. (2006) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2005.09.007 · Cited by 69 · see citing works
Chan, Y., Hosoda, K., Chin-Ju, T. S. A. I., Yamamoto, S., & Ming-Fu, W. A. N. G. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.266 · Cited by 68 · see citing works
Yao, Y., & Vieira, A. V. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.07.015 · Cited by 68 · see citing works
Hasanein, P. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.2.14 · Cited by 67 · see citing works
Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage
Ahmet, I., Spangler, E. L., Shukitt‐Hale, B., Juhaszova, M., Sollott, S. J., Joseph, J. A., Ingram, D. K., & Talan, M. I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005954 · Cited by 67 · see citing works
Self-citationReversal of memory deficits by Coriandrum sativum leaves in mice
Mani, V., Parle, M., Ramasamy, K., & Majeed, A. B. A. (2010) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4171 · Cited by 64 · see citing works
Neuro-consequences of the spaceflight environment
Mhatre, S. D., Iyer, J. S., Puukila, S., Paul, A. M., Tahimic, C. G. T., Rubinstein, L., Lowe, M. G., Alwood, J. S., Sowa, M. B., Bhattacharya, S., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.055 · Cited by 63 · see citing works
Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats
Shukitt‐Hale, B., Kalt, W., Carey, A. N., Vinqvist, M. R., McDonald, J. E., & Joseph, J. A. (2008) · Nutrition · doi:10.1016/j.nut.2008.10.018 · Cited by 63 · see citing works
Self-citationYe, H., Ye, B., & Wang, D. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.12.001 · Cited by 62 · see citing works
Acosta, S., Jernberg, J. N., Sanberg, C. D., Sanberg, P. R., Small, B. J., Gemma, C., & Bickford, P. C. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.1011 · Cited by 62 · see citing works
Self-citationVitamins E and C pretreatment prevents ovariectomy-induced memory deficits in water maze
Monteiro, S. C., Matté, C., Bavaresco, C. S., Netto, C. A., & Wyse, Â. T. D. S. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.08.002 · Cited by 61 · see citing works
Learning and memory deficits in rats induced by chronic thinner exposure are reversed by melatonin
Baydaş, G., Özveren, F., Akdemir, İ., Tuzcu, M., & Yaşar, A. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00212.x · Cited by 61 · see citing works
Neuroprotective effect of Spirulina in cerebral ischemia–reperfusion injury in rats
Thakur, S., & Sravanthi, R. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0440-5 · Cited by 60 · see citing works
Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?
Teixeira, J., Silva, T., Andrade, P. B., & Borges, F. (2013) · Current Medicinal Chemistry · doi:10.2174/1871523011320240001 · Cited by 59 · see citing works
Cartford, M. C., Gemma, C., & Bickford, P. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05813.2002 · Cited by 57 · see citing works
Self-citation
- Authors
- Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J.
- Affiliations
- Veterans Health Administration (US)
- University of Pennsylvania (US)
- University of Colorado Health (US)
- United States Department of Agriculture (US)
- Corresponding author
- Bickford, Paula C
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 866
- Issue
- 1-2
- Pages
- 211-217
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2048534671
- Cited by
- 298
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 14
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04418, P01AG004418, AG00728)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- antioxidant diet, cerebellum, Purkinje cells, beta-adrenergic receptors, aging, motor learning, norepinephrine, reactive oxygen species, free radical theory of aging, spinach, strawberry, blueberry, dietary intervention, age-related decline
- MeSH terms
- Aging, Animals, Antioxidants, Cerebellar Cortex, Diet, Free Radicals, Fruit, Learning, Male, Motor Activity, Norepinephrine, Purkinje Cells, Rats, Inbred F344, Receptors, Adrenergic, beta, Neuroprotective Agents, Spinacia oleracea, Rats
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