Cited by 299Phytochemicals and Antioxidant ActivitiesMotor Control and AdaptationAntioxidant Activity and Oxidative Stress

Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats

Bickford, Paula C, Gould, Thomas, Briederick, Lori, Chadman, Kathy, Pollock, Amber, Young, David, Shukitt-Hale, Barbara, Joseph, James·2000·Brain Research

Abstract

The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.

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Crossref · 10.1016/s0006-8993(00)02280-0

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]

  • Treatment with Spirulina-enriched diets reduces pro-inflammatory cytokines in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]

  • Treatment with Spirulina-enriched diets ameliorates both spatial and motor learning in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]

  • Treatment with Spirulina-enriched diets reduces malondialdehyde (MDA) levels in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]

  • During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to detrimental effects of oxidative stress.

    “During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]

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Authors
Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J.
Affiliations
  • Veterans Health Administration (US)
  • University of Pennsylvania (US)
  • University of Colorado Health (US)
  • United States Department of Agriculture (US)
Corresponding author
Bickford, Paula C
Venue
Brain Research
Publisher
Elsevier BV
Published
2000-06
Volume
866
Issue
1-2
Pages
211-217
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2048534671
Cited by
298
References
27
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 14
FWCI
8.68
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG04418, P01AG004418, AG00728)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
antioxidant diet, cerebellum, Purkinje cells, beta-adrenergic receptors, aging, motor learning, norepinephrine, reactive oxygen species, free radical theory of aging, spinach, strawberry, blueberry, dietary intervention, age-related decline
MeSH terms
Aging, Animals, Antioxidants, Cerebellar Cortex, Diet, Free Radicals, Fruit, Learning, Male, Motor Activity, Norepinephrine, Purkinje Cells, Rats, Inbred F344, Receptors, Adrenergic, beta, Neuroprotective Agents, Spinacia oleracea, Rats

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